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Procarbazine (Matulane)

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An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.

Also Known As:

Matulane; Procarbazine Hydrochloride; Cambridge Laboratories Brand of Procarbazine Hydrochloride; Natulan; Procarbazine Monohydrobromide; Procarbazine Monohydrochloride; Roche Brand of Procarbazine Hydrochloride; Sigma-Tau Brand of Procarbazine; Sigma-Tau Brand of Procarbazine Hydrochloride; Hydrochloride, Procarbazine; Monohydrobromide, Procarbazine; Monohydrochloride, Procarbazine; Sigma Tau Brand of Procarbazine Hydrochloride; Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-

Networked: 971 relevant articles (84 outcomes, 186 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amides: 231
  - Benzamides: 80
    - Procarbazine: 971
- Carboxylic Acids: 83
  - Carbocyclic Acids
    - Benzoic Acids: 18
      - Benzamides: 80
        Procarbazine: 971
        COPP protocol: 22
        COP-BLAM protocol: 7
        OPPA protocol: 7
        THP-COPBLM regimen: 4
        BEACOPP protocol: 3
        MOPP protocol: 3
        PCV protocol: 3
        methylazoxyprocarbazine: 2
        BCPP protocol: 1
        BOPP protocol: 1
        BVCPP protocol: 1
        C'MP protocol: 1
        CAMP protocol: 1
        CEP regimen: 1
        CVPP regimen: 1
        Dexa-PAMB protocol: 1
        LOPP protocol 2: 1
        MCPP protocol: 1
        PRIME protocol: 1
        ProMACE-MOPP protocol: 1
        SIOP-II protocol: 1
        TPDCV protocol: 1
        VAP combination: 1
        AVN protocol
        AVPP protocol
        azoprocarbazine
        BEMP protocol
        benzylazoxyprocarbazine
        BMPD protocol
        CAMP-L protocol
        CCVPP protocol
        CE-AVN protocol
        CEPP protocol
        CHIVPP protocol
        CHLOROPP protocol
        ChlVPP protocol
        ChlVPP-EVA regimen
        CMOPP protocol
        CMPP protocol
        CODBLAM IV protocol
        COFP protocol 1
        COMP-1 protocol
        COMP-VAN protocol
        COPP-ABVD protocol
        CVPP I protocol
        CVPP protocol
        CVPPABO protocol
        DFMO-PCV protocol
        DOPP-protocol
        DVPP protocol
        ECAPP protocol
        EPVP protocol
        FONP protocol
        LCOMP protocol
        LOPP protocol 1
        LTPP protocol
        ML-Y1 protocol
        MMPP protocol
        MOP protocol
        MOP-BAP protocol
        MOPP-ABV protocol
        MOPP-Bleo protocol
        MOPPEBVCAD protocol
        MPP protocol
        MV26PD protocol
        MVPF protocol
        MVPP protocol
        MVPP-Bleo protocol
        MVVPP protocol
        N-isopropyl-4-formylbenzamide
        N-isopropyl-alpha-(2-methylhydrazo)-4-toluamide
        NOPP protocol
        OEPP protocol
        OPP protocol
        PAVe protocol 1
        PCAV protocol
        PMV protocol
        POCC protocol
        Pro-MACE-C-MOPP protocol
        TPDC-FuHu protocol
        VAMP protocol
        VAPE protocol
        VCDP protocol
        VECABOP protocol
        VEPEMB protocol
        VIPP-BM protocol
        VPC protocol
        vvp protocol

Experts

1.	van den Bent, Martin J: 17 articles (12/2015 - 02/2005)
2.	Engert, Andreas: 13 articles (09/2013 - 01/2002)
3.	Diehl, Volker: 12 articles (09/2013 - 01/2002)
4.	Kros, Johan M: 10 articles (01/2015 - 02/2005)
5.	Brandes, Alba A: 10 articles (11/2013 - 01/2002)
6.	Gorlia, Thierry: 9 articles (11/2013 - 06/2006)
7.	Taphoorn, Martin J B: 8 articles (04/2015 - 06/2006)
8.	Idbaih, Ahmed: 7 articles (08/2015 - 03/2010)
9.	Weller, Michael: 7 articles (12/2013 - 10/2002)
10.	Lacombe, Denis: 7 articles (11/2013 - 06/2006)

Related Diseases

1.	Hodgkin Disease (Hodgkin's Disease) 01/01/1996 - "Detection of DNA methylation adducts in Hodgkin's disease patients treated with procarbazine." 04/01/1991 - "In the other, the RRM attacks may have been associated with procarbazine therapy applied for Hodgkin's disease. " 09/01/1979 - "Procarbazine [N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride] is used to treat Hodgkin's disease. " 02/01/1979 - "From the incidence of patients with Hodgkin's disease (1 : 42 000) the calculated population dose of procarbazine is 5.12 micrograms/kg. Assuming equal sensitivity between the sexes we can calculate, for an estimated number of 30 000 genes, the induction of about 22 mutations per million children due to procarbazine treatment. " 02/01/1979 - "Procarbazine is used in drug-combination treatment of Hodgkin's disease. "
2.	Neoplasms (Cancer) 01/01/1969 - "Further studies on the tumor-inhibitory and tumor-inducing properties of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride (procarbazine hydrochloride)." 01/01/2014 - "The authors urge clinicians to ensure depression is adequately managed in cancer patients who are undergoing procarbazine therapy, starting with typical first-line antidepressant agents." 07/01/1991 - "The isomeric azoxy metabolites of procarbazine have recently been identified as the precursors of species responsible for both the anti-cancer efficacy and toxic effects mediated by this drug. " 12/15/1989 - "Ninety-nine patients with primary recurrent malignant tumors of the central nervous system were treated with procarbazine as a single agent. " 11/01/1989 - "Toxic effects resulted when procarbazine, a drug of this class, was used in treating a child with a CNS tumor. "
3.	Glioma (Gliomas) 07/21/2003 - "Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas." 01/01/2008 - "Procarbazine--a traditional drug in the treatment of malignant gliomas." 09/01/2006 - "Procarbazine hydrochloride (PCB) is one of the few anticancer drugs with activity against high-grade gliomas. " 07/21/2003 - "Procarbazine (PCB) has been used for treating gliomas for many years and here both agents were combined in the treatment. " 01/01/1986 - "Radiation therapy alone and radiation therapy plus chemotherapy using nitrosoureas or procarbazine have been proved statistically to be more effective for malignant gliomas than supportive care and radiation therapy alone, respectively. "
4.	Lymphoma (Lymphomas) 12/01/2014 - "Procarbazine (P) is an effective chemotherapeutic drug especially used in lymphoma treatment; however testicular toxicity is a limiting factor. " 04/01/2006 - "Procarbazine hydrochloride is an oral alkylating agent with activity against lymphoma. " 10/01/2002 - "The vast majority of men receiving procarbazine-containing regimens for the treatment of lymphomas are rendered permanently infertile. " 12/01/1998 - "The vast majority of men receiving procarbazine-containing regimens for the treatment of lymphomas become permanently infertile. " 06/01/1973 - "[Clinical experience with procarbazine in malignant lymphomas--single and combination (VENP) therapy]."
5.	Glioblastoma (Glioblastoma Multiforme) 02/01/2007 - "Feasibility and response to 1-(4-amino-2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride chemotherapy with pre-treated procarbazine for elderly patients with newly diagnosed glioblastoma." 07/15/1997 - "A methylator-resistant human glioblastoma multiforme xenograft, D-245 MG (PR), in athymic nude mice was established by serially treating the parent xenograft D-245 MG with procarbazine. " 08/01/2001 - "In a pivotal randomized, international phase II trial comparing temozolomide (n = 112) with procarbazine (n = 113) in patients with glioblastoma multiforme, temozolomide significantly improved median and 6-month progression-free survival and 6-month overall survival. " 12/01/2002 - "A randomized phase II trial demonstrates that temozolomide provides longer progression-free survival and better quality of life than standard-dose procarbazine in patients with recurrent glioblastoma multiforme. " 01/01/2002 - "Temozolomide in patients with glioblastoma at second relapse after first line nitrosourea-procarbazine failure: a phase II study."

Related Drugs and Biologics

1.	Vincristine (Oncovin)
2.	Prednisone (Sone)
3.	Doxorubicin (Adriamycin)
4.	Bleomycin (Blenoxane)
5.	Mechlorethamine (Nitrogen Mustard)
6.	Vinblastine (Vinblastine Sulfate)
7.	Cyclophosphamide (Cytoxan)
8.	Lomustine (CCNU)
9.	Etoposide (VP 16)
10.	Dacarbazine (DIC)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Salvage Therapy