Abstract | BACKGROUND: METHODS AND RESULTS: After MI, rats were divided into 4 groups: 1) untreated animals, 2) lisinopril treatment (20 mg/kg/day), 3) losartan treatment (20 mg/kg/day), and 4) lisinopril plus losartan treatment. After 3 months, the cardiac parameters studied were: mortality, fibrosis ( hydroxyproline), hypertrophy (ventricular weight/body weight ratio [VW/BW]), left ventricular enlargement (volume at end-diastolic pressure equaled zero/ body weight ratio [V0/BW]), and ventricular function (isovolumetric developed pressure, dp/dt, -dp/dt). A lowest mortality rate in the animals treated with the combination of both ACE inhibitor and AT(1) receptor antagonist was observed. Although lisinopril and losartan significantly decreased VW/BW ratio, when administered concomitantly, VW/BW ratio was lower than when either agent was administered individually. There were no differences in right ventricle hydroxyproline concentration. Only combination therapy decreased V0/BW ratio. The treatment with lisinopril plus losartan resulted in increases in the development of pressure versus untreated group; without alteration in dp/dt and -dp/dt. CONCLUSIONS:
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Authors | L A Zornoff, S A Paiva, B B Matsubara, L S Matsubara, J Spadaro |
Journal | Journal of cardiovascular pharmacology and therapeutics
(J Cardiovasc Pharmacol Ther)
Vol. 5
Issue 3
Pg. 203-9
(Jul 2000)
ISSN: 1074-2484 [Print] United States |
PMID | 11150409
(Publication Type: Journal Article)
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Chemical References |
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
- Receptor, Angiotensin, Type 1
- Receptor, Angiotensin, Type 2
- Receptors, Angiotensin
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Topics |
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology, therapeutic use)
- Animals
- Drug Therapy, Combination
- Male
- Myocardial Infarction
(drug therapy, physiopathology)
- Rats
- Rats, Wistar
- Receptor, Angiotensin, Type 1
- Receptor, Angiotensin, Type 2
- Receptors, Angiotensin
(therapeutic use)
- Ventricular Remodeling
(drug effects, physiology)
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