[Evaluation of CYFRA 21-1 and ProGRP in serum and bronchoalveolar lavage fluid of patients with benign lung disease].

Abstract

CYFRA 21-1 and ProGRP have recently been established as new tumor markers for lung cancer. However, there are few reports evaluating concentrations in their bronchoalveolar lavage (BAL) fluid. In this study, we examined 81 patients with benign lung disease. The mean values of CYFRA 21-1 in the BAL fluid of each lung disease were as follows: bronchiolitis obliterans organizing pneumonia (BOOP), 3.9 +/- 2.1 ng/ml (positive rate 50%); collagen vascular disease associated interstitial pneumonia (CVD-IP), 10.7 +/- 15.7 ng/ml (positive rate 50%); diffuse panbronchiolitis (DPB), 4.2 +/- 6.4 ng/ml (positive rate 29%); idiopathic pulmonary fibrosis (IPF), 1.5 +/- 2.1 ng/ml (positive rate 17%); pulmonary infiltration with eosinophilia, 6.3 +/- 7.1 ng/ml (positive rate 44%); sarcoidosis, 4.6 +/- 6.2 ng/ml (positive rate 27%); and healthy volunteer (HV), 0.6 +/- 0.6 ng/ml; and total, 4.4 +/- 5.6 ng/ml (positive rate 32%). The mean values of ProGRP in the BAL fluid were as follows: DPB, 5.0 +/- 7.6 pg/ml (positive rate 0%); IPF, 6.4 +/- 10.6 pg/ml (positive rate 0%); HV, 12.4 +/- 8.3 pg/ml; and total, 5.6 +/- 8.7 pg/ml (positive rate 0%). These results indicate that the two tumor markers have no disease specificity in benign lung disease.

• Authors: Y Matsubara, T Iwashita, Y Ishimatsu, C Shikuwa, J Kadota, S Kohno
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 38 Issue 9 Pg. 659-64 (Sep 2000) ISSN: 1343-3490 [Print] Japan
• PMID: 11109801 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigens, Neoplasm
• Keratin-19
• Peptide Fragments
• Peptides
• Recombinant Proteins
• antigen CYFRA21.1
• pro-gastrin-releasing peptide (31-98)
• Keratins

Topics

• Antigens, Neoplasm (blood)
• Bronchoalveolar Lavage Fluid (chemistry)
• Cryptogenic Organizing Pneumonia (metabolism)
• Humans
• Keratin-19
• Keratins
• Lung Diseases (metabolism)
• Lung Diseases, Interstitial (metabolism)
• Peptide Fragments (blood)
• Peptides (blood)
• Pulmonary Eosinophilia (metabolism)
• Recombinant Proteins (blood)