Abstract |
The aim was to study the frequently found white-matter changes on computerized tomography (CT) in patients with dementia and to relate these changes to clinical regional brain symptomatology, vascular factors, albumin ratio [ indicator of blood-brain barrier (BBB) function] and other CT changes. The study included 85 patients, average age 71 +/- 8, with Alzheimer's disease (n = 56) and vascular dementia (n = 29), who underwent CT (Siemens Somatome DR 1) of the brain. They were inpatients in a psychiatric department specialized in dementia investigations. The degree of CT white-matter changes (absence, mild-moderate, severe) was the basis for the division of the patients into three groups. As the patients without white-matter changes were significantly younger than those with such changes, all statistical analyses were controlled for age. Subcortical symptomatology was significantly more frequent in the group with severe white-matter changes, whereas the reverse was true for parietal symptomatology. Diabetes mellitus, hypertension, ischemic cardiac disease and lacunas were significantly more common in patients with white-matter changes, whereas the frequency of transient ischemic attack/ stroke episodes did not differ significantly between the groups. The albumin ratio was significantly higher in the groups with white-matter changes and highest in the group with severe white-matter changes. The findings indicate that white-matter changes in demented patients are at least partially an age- and stroke-independent disease manifestation of the vascular system and is associated with a specific symptom pattern. BBB dysfunction may be the link between the vasculature and the tissue damage.
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Authors | A Wallin, M Sjögren, A Edman, K Blennow, B Regland |
Journal | European neurology
(Eur Neurol)
Vol. 44
Issue 4
Pg. 229-35
( 2000)
ISSN: 0014-3022 [Print] Switzerland |
PMID | 11096223
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2000 S. Karger AG, Basel |
Chemical References |
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Topics |
- Aged
- Albumins
(cerebrospinal fluid)
- Blood-Brain Barrier
(physiology)
- Brain Infarction
(etiology, pathology)
- Cerebral Arteries
(pathology, physiopathology)
- Cerebrovascular Disorders
(complications, pathology, physiopathology)
- Dementia
(etiology, pathology, physiopathology)
- Disease Progression
- Female
- Humans
- Male
- Nerve Fibers, Myelinated
(pathology)
- Risk Factors
- Serum Albumin
(metabolism)
- Telencephalon
(blood supply, pathology, physiopathology)
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