Abstract | AIM: MATERIALS AND METHODS: RESULTS: Mean level of P-selectin in blood plasma of patients with AMI (1 day) (361 +/- 18 ng/ml), MA (410 +/- 31 ng/ml) and PPH (627 +/- 83 ng/ml) was increased in comparison with the group of healthy donors (269 +/- 12 ng/ml) (everywhere p < 0.001). In AMI, P-selectin was increased on day 1 only, on days 2, 3 and 10-14 of the disease the level of P-selectin was significantly lower than on day 1 and did not differ from the control level in the group of donors. In patients with MA a significant correlation was detected between plasma content of P-selectin and platelet activation marker PF4 (r = 0.606, P = 0.007) and in patients with PPH between the content of P-selectin and another platelet activation marker TXB2 (r = 0.622, p = 0.013). However, no correlation was found in PPH patients between the content of P-selectin and markers of endothelial activation and/or damage (endothelin-1 and 6-keto-PGF1 alpha). Difference in the concentration of P-selectin in patients with or without end-points during the follow-up period was detected in patients with AMI (353 +/- 14 ng/ml and 451 +/- 24 ng/ml, p = 0.009) and PPH (477 +/- 58 ng/ml and 927 +/- 184 ng/ml, p = 0.017) but not with MA (426 +/- 37 ng/ml and 361 +/- 24 ng/ml, p = 0.295). CONCLUSION: The level of P-selectin in plasma was increased in patients with acute thrombosis (AMI, 1 day) as well as in patients without clinical signs of thrombosis but with a massive injury of the vasculature (MA and PPH). The increase of P-selectin was, presumably, caused by its secretion from activated platelets since its concentration in plasma correlated with platelet concentration but not endothelial activation markers. Preliminary data indicate that blood plasma soluble P-selectin may be considered as a potential prognostic marker in AMI and PPH.
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Authors | A V Semenov, M Ia Kogan-Ponomarev, M Ia Ruda, A L Komarov, E P Panchenko, I E Chazova, A V Mazurov |
Journal | Terapevticheskii arkhiv
(Ter Arkh)
Vol. 72
Issue 4
Pg. 15-20
( 2000)
ISSN: 0040-3660 [Print] Russia (Federation) |
Vernacular Title | Rastvorimuĭ P-selektin - marker aktivatsii trombotsitov i porazheniia sosudistoĭ stenki: povyshenie ego urovnia v plazme krovi pri infarkte miokarda, rasprostranennom ateroskleroze i pervichnoĭ legochnoĭ gipertonii. |
PMID | 10833791
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Biomarkers
- Endothelin-1
- P-Selectin
- Platelet Factor 4
- Thromboxane B2
- 6-Ketoprostaglandin F1 alpha
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Topics |
- 6-Ketoprostaglandin F1 alpha
(blood)
- Adolescent
- Adult
- Aged
- Arteriosclerosis
(blood)
- Biomarkers
(blood)
- Blood Coagulation
(physiology)
- Blood Vessels
(injuries)
- Endothelin-1
(blood)
- Endothelium, Vascular
(metabolism)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Hypertension, Pulmonary
(blood)
- Male
- Middle Aged
- Myocardial Infarction
(blood)
- P-Selectin
(blood)
- Platelet Activation
- Platelet Factor 4
(metabolism)
- Prognosis
- Solubility
- Thromboxane B2
(blood)
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