Abstract | BACKGROUND: Antagonists of platelet-activating factor (PAF) reduce myocardial postischemia reperfusion injury when given before the onset of ischemia. However, the effects of PAF antagonists when administered at a clinically modelled time (during ischemia but before reperfusion) are controversial. Moreover, the extended survival (eight day) and the characteristics of scar formation after treatment with PAF antagonists have not been investigated. OBJECTIVES: ANIMALS AND METHODS: Swine underwent regional myocardial ischemia for 60 mins by ligation of the left anterior descending coronary artery, followed by reperfusion for eight days. The treated group (n=7) received PAF antagonist TCV-309 (0.1 mg/kg) 45 mins after ligation; the untreated group (n=7) received vehicle only. RESULTS: Untreated animals experienced significantly (P<0.001) lower systemic arterial blood pressure during the reperfusion period than animals treated with TCV-309. Furthermore, untreated animals required significantly more (P<0.01) antiarrhythmic and inotropic support. Only two of seven animals in the untreated group survived, which was significantly different (P<0.05) from the six of seven treated animals that survived for eight days. Morphometric analyses did not show differences between groups in the characteristics of scar formation following reperfusion for eight days. CONCLUSIONS:
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Authors | E B Loucks, A K Qayumi, D V Godin, J C English, S P Lim, T Al Mahmeed, S Gul |
Journal | The Canadian journal of cardiology
(Can J Cardiol)
Vol. 16
Issue 4
Pg. 497-504
(Apr 2000)
ISSN: 0828-282X [Print] England |
PMID | 10787465
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Isoquinolines
- Platelet Aggregation Inhibitors
- Pyridinium Compounds
- Tetrahydroisoquinolines
- TCV 309
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Topics |
- Animals
- Female
- Isoquinolines
(therapeutic use)
- Myocardial Infarction
(drug therapy, mortality)
- Myocardial Reperfusion
- Myocardial Reperfusion Injury
(drug therapy, mortality)
- Platelet Aggregation Inhibitors
(therapeutic use)
- Pyridinium Compounds
(therapeutic use)
- Random Allocation
- Swine
- Tetrahydroisoquinolines
- Time Factors
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