Surgical results in patients with hepatitis B-related hepatocellular carcinoma and positive hepatitis B early antigen.
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| Abstract |
Hepatitis B virus (HBV) infection is the major risk factor in the pathogenesis of hepatocellular carcinoma (HCC). Patients who are positive for hepatitis B early antigen (HBeAg) have active liver disease. The present study aimed to evaluate the possible role of HBeAg in patients with resectable HCC. A series of 249 HCC patients with complete preoperative hepatitis marker who had undergone potentially curative resection were enrolled. Patients with hepatitis C virus infection were excluded. Of these patients, 27 were positive for hepatitis B surface antigen (HBsAg) and HBeAg (group I), 171 were positive for HBsAg and negative for HBeAg (group II), and 51 were negative for hepatitis B markers (group III). The clinicopathologic features and postoperative survivals were compared among the three groups. The prevalence of HBeAg was 10.8%. Group I patients were significantly younger and had worse liver function, smaller tumors, and a higher incidence of liver cirrhosis and chronic active hepatitis than those in groups II and III. No increase in tumor invasiveness was noted in group I patients. The operative morbidity, mortality, and postresection survival were comparable among the three groups. Our findings indicated that HBeAg positivity is not a negative factor for resection in HCC patients and has no significant influence on postresection survival.
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| Authors | J H Chen, G Y Chau, W Y Lui, S H Tsay, K L King, C C Loong, C Y Hsia, C W Wu |
| Journal | World journal of surgery (World J Surg) Vol. 24 Issue 3 Pg. 383-7; discussion 387-8 (Mar 2000) ISSN: 0364-2313 [Print] United States |
| PMID | 10658077 (Publication Type: Journal Article) |
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