Promotion of NCI-Black-Reiter male rat bladder carcinogenesis by dimethylarsinic acid an organic arsenic compound.

Abstract	Dimethylarsinic acid (DMAA) is a major metabolite of inorganic arsenicals in mammals. In the present study, we investigated its promoting effects on urinary bladder carcinogenesis in NCI-Black-Reiter (NBR) rats, which lack alpha2u-globulin synthesizing ability. Male 9-14-week-old NBR rats were treated sequentially with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 4 weeks and then given 100 ppm DMAA in their drinking water (group 1) for 32 weeks. Induction of preneoplastic lesions (papillary or nodular hyperplasia) in this DMAA-treated group was significantly increased as compared to the carcinogen alone control group (P < 0.01). The development of carcinomas was also enhanced and a significant increase in the 5-bromo-2'-deoxyuridine (BrdU) labeling index of the urinary bladder epithelial cells was observed for the DMAA treatment group. These results indicate that DMAA has promoting effects on urinary bladder carcinogenesis even in NBR rats, so its effects are not dependent on the presence of alpha2u-globulin.
Authors	W Li, H Wanibuchi, E I Salim, S Yamamoto, K Yoshida, G Endo, S Fukushima
Journal	Cancer letters (Cancer Lett) Vol. 134 Issue 1 Pg. 29-36 (Dec 11 1998) ISSN: 0304-3835 [Print] Ireland
PMID	10381127 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Alpha-Globulins DNA, Neoplasm Herbicides alpha 2u globulin Butylhydroxybutylnitrosamine Cacodylic Acid
Topics	Alpha-Globulins (analysis) Animals Butylhydroxybutylnitrosamine Cacodylic Acid (adverse effects, urine) Carcinogenicity Tests DNA, Neoplasm (biosynthesis, drug effects) Herbicides (adverse effects) Hyperplasia (chemically induced) Immunohistochemistry Kidney (chemistry, cytology) Male Precancerous Conditions (chemically induced, pathology) Rats Rats, Inbred F344 Rats, Inbred Strains Urinary Bladder (drug effects, pathology) Urinary Bladder Neoplasms (chemically induced, pathology)

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