Reduction in tumor formation on polyethylene by collagen immobilization.

Abstract

After surface modification with collagen immobilization through covalent binding, porous polyethylene pieces were implanted subcutaneously into the back of rats for 1 year and the tumorigenesis-reducing effect was examined. In the virgin pieces without collagen immobilization, tumors were observed in 11 out of 24 pieces implanted (45.8%). On the other hand, in the collagen immobilized pieces a tumor was found only in one of 24 implanted pieces (4.2%). These results suggest that immobilization of collagen on the surface of an artificial material through covalent binding is very effective for a reduction of tumor formation.

• Authors: Y Kinoshita, T Kuzuhara, M Kobayashi, Y Ikada
• Journal: Journal of long-term effects of medical implants (J Long Term Eff Med Implants) Vol. 5 Issue 4 Pg. 275-84 ( 1995) ISSN: 1050-6934 [Print] United States
• PMID: 10163366 (Publication Type: Journal Article)

Chemical References

• Polyethylenes
• Collagen

Topics

• Animals
• Cell Transformation, Neoplastic (chemically induced, pathology)
• Collagen (metabolism)
• Foreign-Body Reaction (chemically induced, physiopathology)
• Male
• Polyethylenes (administration & dosage, adverse effects, chemistry)
• Rats
• Rats, Wistar
• Time Factors