The association of anti-Ro52 autoantibodies with myositis and scleroderma autoantibodies.
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| Abstract |
The presence of autoantibodies to the Ro52 protein in sera from patients with idiopathic inflammatory myopathies has recently been reported. These antibodies were found predominately in sera with the myositis-specific autoantibody anti-histidyl-tRNA synthetase (anti-Jo-1). In this report, we analysed sera from 216 patients to determine whether anti-Ro52 antibodies are associated with myositis autoantibodies other than anti-Jo-1. These included sera containing antibodies that recognize threonyl- or alanyl-tRNA synthetases, Mi-2, PM-Scl, signal recognition particle (SRP), as well as the systemic sclerosis-related antibodies anti-topoisomerase I (Scl-70) and anti-centromere. A high proportion of sera that contain anti-aminoacyl-tRNA synthetase antibodies, anti-SRP, or anti-PM-Scl antibodies were found to contain antibodies to the Ro52 protein. In contrast, in sera containing anti-Mi-2, anti-Scl-70 or anti-centromere antibodies, anti-Ro52 antibodies were absent or occurred infrequently. In addition, only one serum from 41 rheumatoid arthritis patients was positive for anti-Ro52 autoantibodies. These data indicate that anti-Ro52 antibodies are produced in particular subsets of myositis patients, and are not limited to sera with anti-Jo-1 antibodies.
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| Authors | M B Frank, V McCubbin, E Trieu, Y Wu, D A Isenberg, I N Targoff |
| Journal | Journal of autoimmunity (J Autoimmun) Vol. 12 Issue 2 Pg. 137-42 (Mar 1999) ISSN: 0896-8411 [Print] England |
| PMID | 10047434 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.) |
| Copyright | Copyright 1999 Academic Press. |
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