Anaphase-Promoting Complex-Cyclosome Apc3 Subunit

A highly evolutionarily conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc subunits 6, 7, and 8, have been shown to mediate protein-protein interactions, suggesting that Apc3 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to co-activators and APC-C inhibitors.

Also Known As:

Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome; Anapc3; Apc3 Subunit, Anaphase-Promoting Complex; CDC27 Protein; Apc3 Subunit, Anaphase Promoting Complex; Apc3 Subunit, Anaphase Promoting Complex Cyclosome

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Melloy, Patricia G: 1 article (01/2020)
2.	Gopal, G: 1 article (10/2005)
3.	Rajalekshmy, K R: 1 article (10/2005)
4.	Rajkumar, T: 1 article (10/2005)
5.	Selvaluxmi, G: 1 article (10/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "In comparing these two kinds of cancer genomics data to published large-scale genomic analyses looking for cancer driver genes, ANAPC1 and ANAPC3/CDC27 stood out as being represented in all three types of analyses. "
2.	Uterine Cervical Neoplasms (Cancer of the Cervix) 10/01/2005 - "However, a larger cohort is needed to further confirm the value of CDC27 protein as a predictive marker, for radiation response in cervix cancer."
3.	Carcinoma (Carcinomatosis) 10/01/2005 - "CDC27 protein is involved in radiation response in squamous cell cervix carcinoma."

Related Drugs and Biologics

1.	Anaphase-Promoting Complex-Cyclosome Apc1 Subunit