ortho-Aminobenzoates

Benzoic acids, salts, or esters that contain an amino group attached to carbon number 2 or 6 of the benzene ring structure.

Also Known As:

2-Aminobenzoates; 6-Aminobenzoates; Anthranilates; Anthranilic Acids; o-Aminobenzoates; o-Aminobenzoic Acids; ortho-Aminobenzoic Acids; 6 Aminobenzoates; Acids, Anthranilic; Acids, o-Aminobenzoic; Acids, ortho-Aminobenzoic; o Aminobenzoates; o Aminobenzoic Acids; ortho Aminobenzoates; ortho Aminobenzoic Acids

Networked: 8 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        Aminobenzoates: 1
        ortho-Aminobenzoates: 8
        tranilast: 389
        4-chloro-3',6'-dimethyl-2,2'-iminodibenzoate: 285
        anthranilic acid: 157
        tolfenamic acid: 144
        Glafenine: 80
        3-Hydroxyanthranilic Acid: 78
        floctafenine: 33
        lobenzarit: 29
        avenanthramide-2C: 21
        Fenamates: 20
        fenamic acid: 16
        anthranilamide: 14
        2-(1-(7-methyl-2-morpholin-4-yl-4-oxo-4H-pyrido(1,2-a)pyrimidin-9-yl)ethylamino)benzoic acid: 13
        chlorantranilipole: 11
        5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide: 8
        4-amylcinnamoylanthranilic acid: 7
        methyl 2-((3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino)benzoate: 6
        cinnamyl anthranilate: 5
        enfenamic acid: 4
        FT011: 4
        N-(3',4'-dimethoxycinnamonyl)anthranilic acid: 4
        SSR128129E: 4
        3-oxyanthranilic acid: 3
        cyantraniliprole: 3
        dihydroavenanthramide D: 3
        avenanthramide A: 2
        farnesyl anthranilate: 2
        methyl anthranilate: 2
        1-(4-(6-(2-(isopropylsulfonyl)phenylamino)-9H-purin-2-ylamino)-3-ethoxyphenyl)piperidin-4-ol: 1
        2-fluoro-6-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide: 1
        3',4'-bis(difluoromethoxycinnamoylanthranilate): 1
        3,5-dichloroanthranilic acid: 1
        3-methoxy-4-propargyloxycinnamoyl anthranilate: 1
        AqF026: 1
        avenanthramide B: 1
        damascenine: 1
        EAntS-GS: 1
        ethyl anthranilate: 1
        FR 900405: 1
        FR 900406: 1
        menthyl anthranilate: 1
        methyl N-(3',4'-dihydroxycinnamoyl)-5-hydroxyanthranilate: 1
        methyl N-methylanthranilate: 1
        N-(5'-phosphoribosyl)anthranilate: 1
        sulfonyl anthranilic acid: 1
        1-(m-trifluoromethylphenyl)-N-nitrosoanthranilic acid
        2'(3')-O-(N-methyl)anthraniloylguanosine 5'-triphosphate
        2'-deoxy-3'-(N-methylanthraniloyl)adenosine 5'-diphosphate
        2'-methylanthraniloyl guanosine cyclic monophosphate
        2'-O-(N-methylanthraniloyl)ATP
        2'-O-(N-methylanthraniloyl)guanosine 5'-(gamma-thio)triphosphate
        2'-O-anthraniloyl adenosine monophosphate
        2'-O-anthraniloyl cyclic AMP
        2,3-dihydroxypropyl 5-bromo-N-(2-methyl-3-trifluoromethylphenyl)anthranilate
        2,5-diaminobenzoic acid
        2-((1H-benzimidazol-2-ylmethyl)amino)benzoic acid methyl ester
        2-((3-(3-(but-2-ynyloxy)-4-methoxyphenyl)-1-oxo-2-propenyl)amino)benzoic acid
        2-(2-((1H-indole-2-carbonyl)amino)benzoylamino)-4-phenylbutyric acid
        2-(2-quinolinylazo)-5-dimethylaminobenzoic acid
        2-(3-(3-fluorophenethyloxy)phenylamino)benzamide
        2-(4-(2-(3,4-dichlorophenyl)ethyl)phenylamino)benzoic acid
        2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid
        2-(4-bromophenylsulfonamido)-6-methylbenzoic acid
        2-(4-methoxyphenylsulfonamido)-6-methylbenzoic acid
        2-(butane-1-sulfonylamino)-N-(1-(6-methoxypyridin-3-yl)propyl)benzamide
        2-(nonylsulfonamido)benzoic acid
        2-(oxalylamino)benzoic acid
        2-amino-3-(palmitoylamino)benzoic acid
        2-amino-4,5-difluorobenzoic acid
        2-amino-4,5-diisopropoxybenzoic acid
        2-amino-4,6-dinitrobenzoic acid
        2-amino-4-chlorobenzoic acid
        2-amino-5-fluorobenzoic acid
        2-amino-6-chlorobenzoic acid
        2-amino-6-fluorobenzoic acid
        2-aminobenzoic acid 2-(bromoacetyl)hydrazide
        3'-(methylanthraniloyl)-2'-deoxy-guanosine diphosphate
        3'-anthraniloyl-2'-deoxy-ATP
        3'-O-(N-methylanthraniloyl) ATP
        3'-O-(N-methylanthraniloyl)-2'-deoxyguanosine 5'-(imido)triphosphate
        3'-O-(N-methylanthraniloyl)adenosine 5'-diphosphate
        3'-O-(N-methylanthraniloyl)guanosine 5'-(gamma-thio)triphosphate
        3'-O-anthraniloyl ATP
        3'-O-anthraniloylguanosine diphosphate
        3-enolpyruvoylanthranilate
        3-hydroxy-N-acetylanthranilic acid
        3-hydroxyl-2-N-iso-butyryl-anthranilamide
        4'-(bromoacetamido)-N-(2,3-dimethylphenyl)anthranilic acid
        4'-amidinophenyl-4-chloroanthranilic acid
        4-(2-(2-hydroxybenzyl)-1H-pyrrol-1-yl)-2-((4-hydroxycyclohexyl)amino)benzamide
        4-amino-3-(palmitoylamino)benzoic acid
        4-chloro-2-(2-(4-(hydroxymethyl)phenyl)-1,3-dioxoisoindoline-5-carboxamido)benzoic acid
        4-chloro-5-sulfamoylanthranilic acid
        4-chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid
        4-methyl-3-hydroxyanthranilic acid
        4-methyldiphenylamine-2'-carboxylic acid
        4-nitrophenyl anthranilate
        5'-(4-fluorosulfonylbenzoyl)-2'-(methylanthraniloyl)adenosine
        5'-(4-fluorosulfonylbenzoyl)-3'-(methylanthraniloyl)adenosine
        5'-N-methylanthraniloyladenosine
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - Aminobenzoates: 1
        ortho-Aminobenzoates: 8
        tranilast: 389
        4-chloro-3',6'-dimethyl-2,2'-iminodibenzoate: 285
        anthranilic acid: 157
        tolfenamic acid: 144
        Glafenine: 80
        3-Hydroxyanthranilic Acid: 78
        floctafenine: 33
        lobenzarit: 29
        avenanthramide-2C: 21
        Fenamates: 20
        fenamic acid: 16
        anthranilamide: 14
        2-(1-(7-methyl-2-morpholin-4-yl-4-oxo-4H-pyrido(1,2-a)pyrimidin-9-yl)ethylamino)benzoic acid: 13
        chlorantranilipole: 11
        5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide: 8
        4-amylcinnamoylanthranilic acid: 7
        methyl 2-((3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino)benzoate: 6
        cinnamyl anthranilate: 5
        enfenamic acid: 4
        FT011: 4
        N-(3',4'-dimethoxycinnamonyl)anthranilic acid: 4
        SSR128129E: 4
        3-oxyanthranilic acid: 3
        cyantraniliprole: 3
        dihydroavenanthramide D: 3
        avenanthramide A: 2
        farnesyl anthranilate: 2
        methyl anthranilate: 2
        1-(4-(6-(2-(isopropylsulfonyl)phenylamino)-9H-purin-2-ylamino)-3-ethoxyphenyl)piperidin-4-ol: 1
        2-fluoro-6-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide: 1
        3',4'-bis(difluoromethoxycinnamoylanthranilate): 1
        3,5-dichloroanthranilic acid: 1
        3-methoxy-4-propargyloxycinnamoyl anthranilate: 1
        AqF026: 1
        avenanthramide B: 1
        damascenine: 1
        EAntS-GS: 1
        ethyl anthranilate: 1
        FR 900405: 1
        FR 900406: 1
        menthyl anthranilate: 1
        methyl N-(3',4'-dihydroxycinnamoyl)-5-hydroxyanthranilate: 1
        methyl N-methylanthranilate: 1
        N-(5'-phosphoribosyl)anthranilate: 1
        sulfonyl anthranilic acid: 1
        1-(m-trifluoromethylphenyl)-N-nitrosoanthranilic acid
        2'(3')-O-(N-methyl)anthraniloylguanosine 5'-triphosphate
        2'-deoxy-3'-(N-methylanthraniloyl)adenosine 5'-diphosphate
        2'-methylanthraniloyl guanosine cyclic monophosphate
        2'-O-(N-methylanthraniloyl)ATP
        2'-O-(N-methylanthraniloyl)guanosine 5'-(gamma-thio)triphosphate
        2'-O-anthraniloyl adenosine monophosphate
        2'-O-anthraniloyl cyclic AMP
        2,3-dihydroxypropyl 5-bromo-N-(2-methyl-3-trifluoromethylphenyl)anthranilate
        2,5-diaminobenzoic acid
        2-((1H-benzimidazol-2-ylmethyl)amino)benzoic acid methyl ester
        2-((3-(3-(but-2-ynyloxy)-4-methoxyphenyl)-1-oxo-2-propenyl)amino)benzoic acid
        2-(2-((1H-indole-2-carbonyl)amino)benzoylamino)-4-phenylbutyric acid
        2-(2-quinolinylazo)-5-dimethylaminobenzoic acid
        2-(3-(3-fluorophenethyloxy)phenylamino)benzamide
        2-(4-(2-(3,4-dichlorophenyl)ethyl)phenylamino)benzoic acid
        2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid
        2-(4-bromophenylsulfonamido)-6-methylbenzoic acid
        2-(4-methoxyphenylsulfonamido)-6-methylbenzoic acid
        2-(butane-1-sulfonylamino)-N-(1-(6-methoxypyridin-3-yl)propyl)benzamide
        2-(nonylsulfonamido)benzoic acid
        2-(oxalylamino)benzoic acid
        2-amino-3-(palmitoylamino)benzoic acid
        2-amino-4,5-difluorobenzoic acid
        2-amino-4,5-diisopropoxybenzoic acid
        2-amino-4,6-dinitrobenzoic acid
        2-amino-4-chlorobenzoic acid
        2-amino-5-fluorobenzoic acid
        2-amino-6-chlorobenzoic acid
        2-amino-6-fluorobenzoic acid
        2-aminobenzoic acid 2-(bromoacetyl)hydrazide
        3'-(methylanthraniloyl)-2'-deoxy-guanosine diphosphate
        3'-anthraniloyl-2'-deoxy-ATP
        3'-O-(N-methylanthraniloyl) ATP
        3'-O-(N-methylanthraniloyl)-2'-deoxyguanosine 5'-(imido)triphosphate
        3'-O-(N-methylanthraniloyl)adenosine 5'-diphosphate
        3'-O-(N-methylanthraniloyl)guanosine 5'-(gamma-thio)triphosphate
        3'-O-anthraniloyl ATP
        3'-O-anthraniloylguanosine diphosphate
        3-enolpyruvoylanthranilate
        3-hydroxy-N-acetylanthranilic acid
        3-hydroxyl-2-N-iso-butyryl-anthranilamide
        4'-(bromoacetamido)-N-(2,3-dimethylphenyl)anthranilic acid
        4'-amidinophenyl-4-chloroanthranilic acid
        4-(2-(2-hydroxybenzyl)-1H-pyrrol-1-yl)-2-((4-hydroxycyclohexyl)amino)benzamide
        4-amino-3-(palmitoylamino)benzoic acid
        4-chloro-2-(2-(4-(hydroxymethyl)phenyl)-1,3-dioxoisoindoline-5-carboxamido)benzoic acid
        4-chloro-5-sulfamoylanthranilic acid
        4-chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid
        4-methyl-3-hydroxyanthranilic acid
        4-methyldiphenylamine-2'-carboxylic acid
        4-nitrophenyl anthranilate
        5'-(4-fluorosulfonylbenzoyl)-2'-(methylanthraniloyl)adenosine
        5'-(4-fluorosulfonylbenzoyl)-3'-(methylanthraniloyl)adenosine
        5'-N-methylanthraniloyladenosine

Experts

1.	Chitlange, Sohan S: 1 article (01/2021)
2.	Kothawade, Prajakta B: 1 article (01/2021)
3.	Thomas, Asha B: 1 article (01/2021)
4.	Crick, Dean C: 1 article (11/2019)
5.	Fontes, Fabio L: 1 article (11/2019)
6.	Hitchings, Reese: 1 article (11/2019)
7.	Kruh-Garcia, Nicole A: 1 article (11/2019)
8.	Kumar, Santosh: 1 article (11/2019)
9.	Lott, J Shaun: 1 article (11/2019)
10.	Nurul Islam, M: 1 article (11/2019)

Related Diseases

1.	Dyslipidemias (Dyslipidemia) 01/01/2021 - "The present review attempts to provide a systematic presentation of the various chemical classes of compounds that have been reported as novel niacin receptor agonists including pyrazole-3-carboxylic acids, urea derivatives, anthranilic acids, biaryl anthranilides, tetrahydro anthranilic acid, xanthines, barbituric acid, bicyclic pyrazole carboxylic acids, pyrido pyrimidinones, pyrazolyl propionyl cyclohexenamides, pyrazole acids etc. Results: As the design of GPR109A receptor agonists offers a promising solution for treatment of dyslipidemia, this review will be beneficial for medicinal and drug discovery chemists to expediate the process of discovery of new class of anti-hyperlipidemic agent with favorable lipid lowering profile with increase in HDL levels. "
2.	Neoplasms (Cancer) 03/01/2016 - "A spectroscopic study of substituted anthranilic acids as sensitive environmental probes for detecting cancer cells." 03/01/2016 - "Anthranilic acids are extremely sensitive environmental probes, and hold promise as general but selective agents for cancer-cell detection if they can be equipped with the appropriate targeting groups. " 03/01/2016 - "The boron-containing anthranilic acids were also evaluated as sensitive fluorescent probes for cancer cells using laser scanning confocal microscopy. " 01/01/2016 - "They were synthesized from substituted anthranilic acids and trimellitic anhydride chloride, followed by reaction with primary amines and were tested for the inhibition of five physiologically relevant CA isoforms, the human (h) hCA I, II, IV, VII and XII, some of which are involved in serious pathologies (CA II, IV and XII in glaucoma; CA VII in epilepsy; CA XII in some solid tumors). "
3.	Tuberculosis (Tuberculoses) 11/01/2019 - "tuberculosis mc2 6230 cultures were treated with anthranilates fluorinated at positions 4, 5, and 6. These compounds inhibited bacterial growth on tryptophan-free media with 4-fluoroanthranilate being more potent than 5-fluoroanthranilate or 6-fluoroanthranilate. "
4.	Seizures (Absence Seizure) 01/01/1983 - "Picolinic, kynurenic, xanthurenic and anthranilic acids are metabolites of L-kynurenine which, when administered intraperitoneally (i.p.) antagonized (in descending order of potency) the seizures induced by intracerebroventricular (i.c.v.) injections of l-kynurenine sulfate in SHR and C57BL/6 mice. "
5.	Schizophrenia (Dementia Praecox) 01/01/2018 - "Participants with deficit schizophrenia show increased IgA responses to xanthurenic acid, picolinic acid, and quinolinic acid and relatively lowered IgA responses to kynurenic and anthranilic acids, as compared to patients with nondeficit schizophrenia. "

Related Drugs and Biologics

1.	Xanthines
2.	Urea (Carbamide)
3.	Solutions
4.	Pyrimidinones
5.	Niacin (Nicotinic Acid)
6.	Lipids
7.	Carboxylic Acids
8.	Acids
9.	barbituric acid (barbiturate)
10.	anthranilic acid (anthranilate)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Injections