Antipsychotic Agents (Antipsychotics)

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

Also Known As:

Antipsychotics; Antipsychotic Drugs; Neuroleptics; Antipsychotic Effect; Antipsychotic Effects; Major Tranquilizers; Neuroleptic Agents; Neuroleptic Drugs; Tranquillizing Agents, Major; Agent, Antipsychotic; Agent, Neuroleptic; Drug, Antipsychotic; Drug, Neuroleptic; Effect, Antipsychotic; Major Tranquilizing Agents; Major Tranquillizing Agents; Medication, Antipsychotic; Tranquilizer, Major; Antipsychotic; Antipsychotic Agent; Antipsychotic Drug; Antipsychotic Medication; Major Tranquilizer; Neuroleptic; Neuroleptic Agent; Neuroleptic Drug; Tranquilizing Agents, Major

Networked: 32019 relevant articles (3013 outcomes, 6365 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 164
  - Therapeutic Uses: 49043
    - Central Nervous System Agents: 56
      - Psychotropic Drugs: 3195
        Tranquilizing Agents: 62
        Antipsychotic Agents: 32019
      - Central Nervous System Depressants: 119
        Tranquilizing Agents: 62
        Antipsychotic Agents: 32019
  - Physiological Effects of Drugs: 1
    - Central Nervous System Depressants: 119
      - Tranquilizing Agents: 62
        Antipsychotic Agents: 32019

Experts

1.	Correll, Christoph U: 298 articles (05/2024 - 11/2003)
2.	Leucht, Stefan: 186 articles (04/2024 - 02/2002)
3.	Kane, John M: 183 articles (05/2024 - 01/2002)
4.	Remington, Gary: 165 articles (10/2023 - 01/2002)
5.	Lieberman, Jeffrey A: 151 articles (01/2023 - 02/2002)
6.	Citrome, Leslie: 144 articles (03/2024 - 01/2002)
7.	Meltzer, Herbert Y: 134 articles (01/2023 - 01/2002)
8.	Uchida, Hiroyuki: 102 articles (05/2024 - 10/2003)
9.	Tiihonen, Jari: 86 articles (04/2024 - 06/2002)
10.	Kennedy, James L: 86 articles (01/2023 - 07/2002)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 06/01/2023 - "With the introduction of neuroleptic medication, the treatment of schizophrenia changed dramatically, and patients often returned to their family in varying stages of partial remission, increasing the burden on relatives. " 06/01/2022 - "Using the most conservative of these estimates, a meta-analysis of treatment effect heterogeneity provided evidence of a marked variability in antipsychotic-specific effects between individuals with schizophrenia, with the top quartile of patients experiencing beneficial treatment effects of 17.7 points or more on the PANSS total score, while the bottom quartile presented a detrimental effect of treatment relative to placebo. " 05/01/2022 - "Second-generation antipsychotics (SGAs) are the most effective treatment for people with schizophrenia. " 01/01/2021 - "The efficacy of antipsychotic medications in the treatment of negative symptoms of schizophrenia is modest at best. " 02/01/2020 - "A major hurdle faced by most schizophrenia patients is the poor efficacy of current antipsychotic medications. "
2.	Psychotic Disorders (Schizoaffective Disorder) 01/01/2020 - "Antipsychotic drugs represent the most effective treatment for chronic psychotic disorders. " 01/01/2003 - "The efficacy of a number of atypical antipsychotics in reducing psychosis without a detrimental effect on motor function has been studied in the group of patients most vulnerable to EPS, those who already have parkinsonian symptoms. " 03/01/2024 - "Non-pharmacological interventions are critically important in older adults with psychosis, especially considering the lack of evidence for the efficacy of antipsychotics and the high risk of side effects. " 11/01/2020 - "Of note, currently used antipsychotic drugs ameliorate psychosis, but they are not very effective in reversing cognitive deficits. " 11/01/2016 - "Up to 40% of those whose psychosis remits after a first episode should be able to achieve a good outcome in the long term either with no antipsychotic medication or with a very low dose."
3.	Bipolar Disorder (Manic Depressive Psychosis) 02/01/2008 - "Children with bipolar disorder have benefited the most from the combination of a mood stabilizer plus an antipsychotic. " 10/01/2015 - "Second generation antipsychotic (SGA) use in bipolar disorder is common and has proven effective in short-term trials. " 12/01/2011 - "The second-generation antipsychotics, with their proven efficacy against manic symptoms, are emerging as candidates for use against the depressive phase of bipolar disorder. " 01/01/2005 - "The atypical antipsychotics, with their proven efficacy against manic symptoms, are emerging as candidates for use against the depressive phase of bipolar disorder. " 01/01/2005 - "Atypical antipsychotics appear to have broadly similar efficacy against manic symptoms of bipolar disorder, but there are important differences in their tolerability profiles, which are likely to be of particular relevance during long-term treatment. "
4.	Mania (Manias) 12/01/2015 - "Combined antipsychotic/mood stabilizer had the highest probability of being the best treatment based on change in mania rating scales (96.1% for all mania scales; 85.5% for Young Mania Rating Scale), and 99.3% for being the best treatment for responders. " 07/01/2010 - "Most second-generation antipsychotics have demonstrated efficacy in the treatment of mania, both in monotherapy and as adjuncts to mood stabilizers. " 08/16/2007 - "With mania or mixed presentation atypical antipsychotics produced significantly better rates of response and symptomatic remission than placebo, with NNTs of about 5 up to six weeks, and 4 at 6-12 weeks, but more adverse event withdrawals (NNH of about 22) in studies of 6-12 weeks. " 09/01/2007 - "Antipsychotics and mood stabilizers are significantly more effective than placebo for the treatment of acute mania. " 09/01/2000 - "Antipsychotics are beneficial for some clinical presentations of mania. "
5.	Treatment-Resistant Schizophrenia 03/01/2003 - "It has been proven effective and significantly superior to placebo, as well as to conventional neuroleptics, in several placebo-controlled, double-blind studies in treatment-resistant schizophrenia. " 04/01/2017 - "This case report describes a forensic psychiatric patient presenting with treatment-resistant schizophrenia and serious interpersonal violence complicated by poor adherence to oral medication who was treated successfully with two concurrent long-acting depot antipsychotics. " 06/01/1995 - "Later on, the development of classical neuroleptics has permitted a better outcome but the persistence of a lack of improvement in certain patients has induced the individuation of treatment-refractory schizophrenia criteria. " 12/01/1994 - "The failure of clinically effective antipsychotics of diverse chemical classes to block the effects of PCP on PPI of acoustic startle suggest that the effects of PCP in this procedure may represent a model of attentional deficits observed in treatment-resistant schizophrenia." 06/01/2005 - "Results from open studies suggest that the combination of ECT and antipsychotics is a very useful and safe strategy for the treatment of refractory schizophrenia. "

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	Clozapine (Clozaril)
3.	Olanzapine (Zyprexa)
4.	Risperidone (Risperdal Consta)
5.	Antidepressive Agents (Antidepressants)
6.	Quetiapine Fumarate (Seroquel)
7.	Aripiprazole (Abilify)
8.	Haloperidol (Haldol)
9.	Lithium
10.	Dopamine (Intropin)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Drug Therapy (Chemotherapy)
4.	Secondary Prevention
5.	Aftercare (After-Treatment)