Respiratory Paralysis

Complete or severe weakness of the muscles of respiration. This condition may be associated with MOTOR NEURON DISEASES; PERIPHERAL NERVE DISEASES; NEUROMUSCULAR JUNCTION DISEASES; SPINAL CORD DISEASES; injury to the PHRENIC NERVE; and other disorders.

Also Known As:

Networked: 313 relevant articles (3 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Breast Neoplasms (Breast Cancer)
3.	Poliomyelitis (Polio)
4.	Poisoning
5.	Dyspnea (Shortness of Breath)

Experts

1.	Chu, Jaw-Ji: 2 articles (11/2012 - 03/2005)
2.	Masmoudi, Hicham: 2 articles (08/2012 - 10/2011)
3.	Similowski, Thomas: 2 articles (08/2012 - 10/2011)
4.	Assouad, Jalal: 2 articles (08/2012 - 10/2011)
5.	Grunenwald, Dominique: 2 articles (08/2012 - 10/2011)
6.	Calvete, Juan J: 2 articles (04/2012 - 08/2011)
7.	Madea, Burkhard: 2 articles (03/2012 - 06/2011)
8.	Kuepper, Uta: 2 articles (03/2012 - 06/2011)
9.	Musshoff, Frank: 2 articles (03/2012 - 06/2011)
10.	Herbstreit, Frank: 2 articles (03/2012 - 06/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Respiratory Paralysis:

1.	IronIBA 07/10/1953 - "[Therapy of poliomyelitic respiratory paralysis with special reference to iron lung]." 01/31/1953 - "[Indications for using iron or electrolung in respiratory paralysis]." 03/16/1956 - "[Respirator treatment, except with iron lung, in respiratory paralysis]." 01/01/1957 - "[Therapy of respiratory paralysis complicating infantile eclampsia by iron lung]." 03/01/1956 - "[Disorders of acid-base equilibrium, a problem in therapy of poliomyelitis patients with respiratory paralysis in iron lungs]."
2.	VenomsIBA 04/01/2013 - "Envenomation can result in various syndromes depending on the snake species: Viperidae venoms are highly inflammatory, hemorrhagic and necrotising, while Elapidae venoms can cause fatal respiratory paralysis. " 04/03/2012 - "Toxicity experiments performed in mice suggest that, at low venom doses, neurotoxicity leading to respiratory paralysis represents the predominant mechanism of prey immobilization and death. " 03/01/1994 - "The onset of complete respiratory paralysis after a lethal dose of whole krait venom (2 mg/kg) was delayed significantly by DAP. " 11/01/2013 - "Patient developed bilateral ptosis six hours after alleged snake bite, soon followed by respiratory paralysis and was treated with Indian polyvalent anti-venom serum. " 03/01/1994 - "The drug 3,4-diaminopyridine (DAP) is effective in other presynaptic paralytic conditions and was therefore tried in anaesthetized rabbits with respiratory paralysis induced by krait (Bungarus fasciatus) venom. "
3.	PotassiumIBA 09/12/1959 - "Respiratory paralysis and severe potassium depletion after ureterosigmoidostomy." 12/01/2009 - "The second case is a 15 years old woman with 26.5 weeks of pregnancy, who suffers a generalized paralysis with blood potassium of 2.7 meq/L, requiring also mechanical ventilation for respiratory paralysis; the final diagnosis was Barterr syndrome, and the medical profile remited after potassium supplement. " 12/01/2009 - "Here we present two cases: in the first one, a 23 years old woman, with 15.5 weeks of gestation has a cuadriplegia associated to blood potassium level of 1.4 meq/L, diagnosed with distal tubular acidosis; she required mechanical ventilation for respiratory paralysis. " 12/01/1999 - "Many may have been a result of hypokalaemia, a complication which was not recognized until 1946; in that year in the Journal of the American Medical Association, Jacob Holler described a patient who developed respiratory paralysis 12h into treatment that, after several hours in an iron lung, was cured by potassium infusion. "
4.	Aromatase (CYP19)IBA 01/01/2003 - "The use of anastrozole, a highly selective nonsteroidal aromatase inhibitor (1 mg daily), successfully induced remission of metastatic tumors in our patient, who is partially recovering from diaphragmatic paralysis."
5.	anastrozole (Arimidex)FDA LinkGeneric 01/01/2003 - "Anastrozole-induced remission of diaphragmatic paralysis from metastatic breast cancer treated with multiple prior therapies." 01/01/2003 - "The use of anastrozole, a highly selective nonsteroidal aromatase inhibitor (1 mg daily), successfully induced remission of metastatic tumors in our patient, who is partially recovering from diaphragmatic paralysis."
6.	3,4-diaminopyridineIBA 03/01/1994 - "The drug 3,4-diaminopyridine (DAP) is effective in other presynaptic paralytic conditions and was therefore tried in anaesthetized rabbits with respiratory paralysis induced by krait (Bungarus fasciatus) venom. " 03/01/1994 - "3,4-Diaminopyridine reverses respiratory paralysis induced by a presynaptically active snake venom and its major neurotoxin."
7.	OxygenIBA 05/01/2010 - "Two patients showed postoperative diaphragmatic paralysis but did not complain of respiratory distress symptoms or need supplemental oxygen after being transferred to the general ward. " 05/01/1983 - "We have observed transient diaphragmatic paralysis with high alveolar to arterial oxygen partial pressure difference following radical neck surgery. " 09/01/1982 - "[Acid-base equilibrium and oxygen-transport functions of the blood in patients with respiratory muscle paralysis after many years of continuous artificial pulmonary ventilation]." 06/01/1955 - "Arterial blood oxygen and carbon dioxide tension studies in the respiratory paralysis of poliomyelitis." 09/01/1953 - "I. Carbon dioxide and oxygen studies in early respiratory paralysis in poliomyelitis."
8.	Carbon DioxideIBA 05/13/1954 - "[Carbon dioxide content of alveolar air in poliomyelitis with respiratory paralysis]." 03/01/1980 - "A 45-yr-old man with limb girdle muscular dystrophy, bilateral diaphragmatic paralysis, chronic carbon dioxide retention, and hypersomnolence was studied to determine the causes of hypoventilation during wakefulness and during sleep. " 06/01/1955 - "Arterial blood oxygen and carbon dioxide tension studies in the respiratory paralysis of poliomyelitis." 09/01/1953 - "I. Carbon dioxide and oxygen studies in early respiratory paralysis in poliomyelitis."
9.	Uridine Diphosphate (UDP)IBA 06/01/2014 - "The degree of impairment of ventilation and exercise performance after unilateral diaphragmatic paralysis (UDP) induced by phrenic nerve injury has been controversial due to heterogeneity in the published clinical studies. " 02/15/2012 - "Patients with unilateral diaphragmatic paralysis (UDP) have been reported to have varied respiratory symptoms and often reduced lung function. " 02/01/2004 - "A patient with unilateral diaphragmatic paralysis (UDP) after cardiac surgery, commonly extubated without any troubles, encounters a serious fetal respiratory complication in a rare case. " 08/01/1991 - "Unilateral diaphragmatic paralysis (UDP) is not an uncommon occurrence after cardiovascular operations. " 01/01/1991 - "Pulmonary function has been studied extensively in patients with unilateral diaphragmatic paralysis (UDP), but there is scarce information regarding the respiratory function during sleep in this condition. "
10.	Atropine (Hyoscyamine)FDA LinkGeneric 03/01/2001 - "It is suggested that the cause of respiratory muscle paralysis may be related to high dose of atropine." 01/01/1978 - "The toxicity of CCC could be reduced by small doses of atropine, but higher atropine doses proved to be unfavourable by aggravating respiratory paralysis. " 10/01/2002 - "[Study on the therapeutic effect of combined use of obidoxime and atropine with respiratory machine on respiratory muscle paralysis caused by omethoate poisoning of rats]." 10/01/2002 - "Combined use of suitable dose of obidoxime and atropine with artificial ventilation for respiratory muscle paralysis caused by omethoate poisoning could promote the recovery of diaphragm function and reduce the death rate in poisoned rats." 10/01/2002 - "To examine the therapeutic effect of combined use of obidoxime and atropine with artificial ventilation on respiratory muscle paralysis caused by omethoate poisoning in rats. "

Therapies and Procedures

1.	Artificial Respiration (Mechanical Ventilation) 11/01/1979 - "Respiratory variability according to sleep states during mechanical ventilation: a polygraphic study in a baby with bilateral diaphragmatic paralysis." 01/01/2014 - "Non-invasive mechanical ventilation (NIV) is considered a treatment option for patients with diaphragmatic paralysis." 08/01/2012 - "Phrenic nerve stimulation for diaphragm pacing allows patients with central respiratory paralysis to be weaned from mechanical ventilation. " 10/01/2011 - "Diaphragm pacing by phrenic nerve (PN) stimulation is currently used for patients with central respiratory paralysis to be weaned from mechanical ventilation. " 03/01/2011 - "Early diaphragmatic plication enhances weaning process and may prevent or minimize the morbidity associated with long-term mechanical ventilation in a neonate with diaphragmatic paralysis."
2.	Tracheotomy 01/01/1988 - "The study suggests tracheotomy should be performed early and it is one of the most important procedures in the treatment of AP with respiratory paralysis." 01/01/1988 - "We attempted to assess the grades of respiratory paralysis and established the criteria for tracheotomy. " 01/01/1988 - "343 of the 504 cases (68.1%) with AP had respiratory paralysis and in 198/504 (39.3%), tracheotomy was performed. " 02/01/1957 - "Three cases of respiratory paralysis treated by pressure breathing through a tracheotomy." 07/14/1955 - "[Tracheotomy in respiratory paralysis]."
3.	Spinal Anesthesia 11/01/1950 - "V. Effect on the circulation of electrophrenic respiration and positive pressure breathing during the respiratory paralysis of high spinal anesthesia." 11/01/2010 - "Studies of patients with cord transection or polio, induced spinal anesthesia, or induced respiratory muscle paralysis indicate that activation of the respiratory muscles is not essential for the perception of dyspnea. "
4.	Aftercare (After-Treatment) 05/01/1983 - "LD50 value was increased to 514 mg/kg body wt. Most animals given a lethal dose died of respiratory paralysis within 3-17 min. In subacute toxicity studies, the rats died within 1-3 days after treatment. "
5.	Mechanical Ventilators (Ventilator) 07/01/2015 - "Respiratory paralysis in IMS, if identified early can reduce the need for ventilator support, morbidity, and mortality. " 01/01/2014 - "His breathing was controlled by a respirator as he had expectoration difficulty and respiratory muscle paralysis. " 04/01/2013 - "The diaphragmatic plication by minimally invasive surgery reduces operative morbidity and facilitates extubation of ventilator-dependent patients with diaphragmatic paralysis. " 06/01/2010 - "Some cases of diaphragmatic paralysis of central causation result in a life of ventilator dependence, even though the peripheral neuromuscular and respiratory systems are intact. " 03/01/2005 - "Diaphragmatic paralysis leads to difficulty of weaning the child from the ventilator surgical plication is an easy and safe procedure that result in early clinical and physiological improvements."