Cord Factors

Toxic glycolipids composed of trehalose dimycolate derivatives. They are produced by MYCOBACTERIUM TUBERCULOSIS and other species of MYCOBACTERIUM. They induce cellular dysfunction in animals.

Also Known As:

Networked: 122 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hunter, Robert L: 7 articles (01/2014 - 08/2003)
2.	Actor, Jeffrey K: 7 articles (01/2014 - 08/2003)
3.	Yano, I: 5 articles (04/2006 - 06/2000)
4.	Actor, J K: 4 articles (01/2009 - 09/2000)
5.	Hunter, R L: 4 articles (01/2009 - 09/2000)
6.	Jagannath, Chinnaswamy: 3 articles (01/2014 - 01/2006)
7.	Hwang, Shen-An: 3 articles (01/2014 - 06/2008)
8.	Luquin, Marina: 3 articles (11/2012 - 10/2002)
9.	Yano, Ikuya: 3 articles (07/2007 - 02/2003)
10.	Olsen, M: 3 articles (08/2005 - 09/2000)

Related Diseases

1.	Neoplasms (Cancer) 08/01/1984 - "Use of covalently bound cord factor analog to increase tumor immunogenicity." 10/01/1976 - "Intralesional administration of killed BCG or Mycobacterium kansasii coated with cord factor, in the same medium, caused regression of established tumors in 48 and 45% of the treated animals, respectively." 06/01/1974 - "Tumor suppression was still detectable 36 days after administration of cord factor. " 10/01/1976 - "Immunotherapy of cancer with nonliving mycobacteria and cord factor (trehalose-6,6'-dimycolate) in aqueous medium." 07/01/1981 - "Tumor regression studies with strain 2 guinea pigs and syngeneic line 10 hepatocellular carcinoma showed that all fractions were effective when combined with trehalose dimycolates and an additional tumor regression factor (previously designated ACP) and incorporated into oil droplets (78 to 100% cures). "
2.	Hepatocellular Carcinoma (Hepatoma) 12/15/1979 - "Immunotherapy of an ascitic rat hepatoma with cord factor (trehalose-6, 6'-dimycolate) and synthetic analogues." 07/01/1981 - "Tumor regression studies with strain 2 guinea pigs and syngeneic line 10 hepatocellular carcinoma showed that all fractions were effective when combined with trehalose dimycolates and an additional tumor regression factor (previously designated ACP) and incorporated into oil droplets (78 to 100% cures). " 10/01/1976 - "Heat-killed BCG, cord factor (trehalose-6,6'-dimycolate), or killed BCG plus cord factor in aqueous medium, admixed with tumor cells and injected into the skin of guinea pigs, inhibited the growth of a hepatocellular carcinoma. " 10/01/1988 - "Regression of line-10 hepatocellular carcinoma by a less toxic cord factor analogue combined with L18-MDP or synthetic lipid A analogues." 12/15/1979 - "The ability of cord factor (trehalose-6, 6'-dimycolate) and a range of shorter carbon chain fatty acid trehalose diesters to suppress growth of an ascitic rat hepatoma has been examined and compared with that of whole, living BCG organisms. "
3.	Pulmonary Tuberculosis 01/01/1997 - "[Serodiagnosis with trehalose-6,6'-dimycolate of pulmonary tuberculosis]." 12/01/1995 - "We have developed a diagnostic method for pulmonary tuberculosis by detecting antibody to cord factor using enzyme-linked immunosorbent assay (ELISA). " 02/01/2001 - "Recently, it has been reported that detection of antibodies against purified cord factor (trehalose-6,6'-dimycolate, TDM), the best studied, most antigenic, and most abundant cell wall component of tubercule bacilli, is very useful for rapid serodiagnosis of pulmonary tuberculosis. " 08/01/2008 - "Molecular interactions of cord factor with dipalmitoylphosphatidylcholine monolayers: implications for lung surfactant dysfunction in pulmonary tuberculosis." 10/01/1993 - "Clinical evaluation of rapid serodiagnosis of pulmonary tuberculosis by ELISA with cord factor (trehalose-6,6'-dimycolate) as antigen purified from Mycobacterium tuberculosis."
4.	Tuberculosis (Tuberculoses) 02/01/1955 - "Studies on the virulence of Tubercle bacilli; the effect of cord factor on murine tuberculosis." 01/01/2012 - "This might facilitate better use of cord factor as an adjuvant for tuberculosis therapy or selection of drug targets involved in its biosynthesis to combat tuberculosis." 12/01/2009 - "tuberculosis using the macroscopic evaluation of colonies combined with cord factor detection under microscopy is a simple, rapid and inexpensive test. " 11/01/2007 - "tuberculosis complex isolation and limited economic resources, cord factor detection is a fast and valid criterion for identifying these mycobacteria using liquid or solid medium. " 01/01/2006 - "Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease."
5.	Granuloma 12/01/2001 - "The biologic effects of the mycobacterial glycolipid trehalose-6,6'-dimycolate (TDM) include granuloma formation and macrophage activation and are dependent on physical conformation. " 07/01/1993 - "Trehalose 6,6' dimycolate (TDM), a mycobacterial glycolipid, induces granulomas and hemorrhagic toxic reactions when administered in oil but not as a suspension in saline. " 07/01/1972 - "These results are discussed in relation to cord factor's role in antimicrobial immunity, granuloma formation, and antitumor immunity." 07/01/1972 - "Cord factor did not induce pulmonary granulomas comparable to those induced by killed BCG. " 07/01/1972 - "Role of cord factor (trehalose-6,6'-dimycolate) in allergic granuloma formation in rabbits."

Related Drugs and Biologics

1.	Antibodies
2.	Vaccines
3.	Anti-Bacterial Agents (Antibiotics)
4.	Agar
5.	Cord Factors
6.	Trehalose
7.	Antigens
8.	Mycolic Acids (Mycolic Acid)
9.	Immunoglobulin G (IgG)
10.	Glycolipids

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Intralesional Injections
3.	Immunotherapy
4.	X-Ray Film
5.	Lasers (Laser)