Acute Aortic Syndrome

A group of aortic diseases presented with acute chest pain. It commonly includes AORTIC DISSECTION; AORTIC INTRAMURAL HEMATOMA; PENETRATING ATHEROSCLEROTIC ULCER and sometimes aortic aneurysms.

Also Known As:

Networked: 141 relevant articles (6 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Abdominal Aortic Aneurysm
2.	Atherosclerosis
3.	COVID-19
4.	Aortic Dissection
5.	Chest Pain (Chest Pains)

Experts

1.	Bossone, Eduardo: 10 articles (12/2021 - 03/2011)
2.	Erbel, Raimund: 9 articles (12/2021 - 05/2009)
3.	Jakob, Heinz: 9 articles (12/2021 - 12/2015)
4.	Gorla, Riccardo: 8 articles (12/2021 - 12/2015)
5.	Tsagakis, Konstantinos: 7 articles (06/2018 - 12/2015)
6.	Jánosi, Rolf Alexander: 6 articles (06/2018 - 12/2015)
7.	Morello, Fulvio: 5 articles (01/2021 - 02/2016)
8.	Nazerian, Peiman: 5 articles (01/2021 - 02/2016)
9.	Schlosser, Thomas: 5 articles (06/2018 - 12/2015)
10.	Kahlert, Philipp: 5 articles (08/2017 - 12/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Aortic Syndrome:

1.	QuercetinIBA 09/30/2020 - "Our results suggest that quercetin might prevent the onset of atherosclerosis-related acute aortic syndromes through its anti-inflammatory and endothelial cell-protective effects." 09/30/2020 - "Preventive Effects of Quercetin against the Onset of Atherosclerosis-Related Acute Aortic Syndromes in Mice."
2.	fibrin fragment D (D-dimer)IBA 01/01/2023 - "This study aimed to investigate and compare the discriminative performance and clinical utility of D-dimer and the neutrophil-to-lymphocyte ratio (NLR) in the early differential diagnosis of acute aortic syndrome (AAS). " 01/01/2021 - "This study adds to the argument for use of D-dimer to help risk stratify patients for the diagnosis of acute aortic syndrome. " 01/01/2021 - "This single centre study found that a diagnostic pathway for acute aortic syndrome including D-dimer could be implemented without a significant increase in test ordering during this first 2 weeks after implementation. " 01/01/2016 - "Diagnostic test accuracy of D-dimer for acute aortic syndrome: systematic review and meta-analysis of 22 studies with 5000 subjects." 03/10/2023 - "Pre-Test Probability Assessment and d-Dimer Based Evaluation in Patients with Previous Acute Aortic Syndrome."
3.	Biomarkers (Surrogate Marker)IBA 02/08/2023 - "Routine Use of a Pocket-Sized Handheld Echoscopic Device Plus a Biomarker by Emergency Medicine Residents with an Early Screening Algorithm for Suspected Type A Acute Aortic Syndrome." 04/01/2022 - "Randomized controlled and prospective studies are warranted to clarify these well-documented results to apply this useful biomarker in clinical practice for patients with the acute aortic syndrome." 04/01/2022 - "Promising biomarker for acute aortic syndrome." 03/01/2021 - "Imaging and Biomarkers in Acute Aortic Syndromes: Diagnostic and Prognostic Implications." 01/01/2017 - "Currently none of the biomarkers can reliably identify acute aortic syndromes. "
4.	clevidipineFDA Link 10/01/2020 - "Clevidipine as a therapeutic and cost-effective alternative to sodium nitroprusside in patients with acute aortic syndromes." 10/01/2020 - "The increasing cost of sodium nitroprusside in the USA led us to assess the efficacy and safety of intravenous clevidipine, a calcium channel blocker with quick onset of action, short half-life and significantly lower costs than sodium nitroprusside, in patients presenting with acute aortic syndrome. " 03/01/2022 - "In recent years, clinical trials have shown that clevidipine has excellent blood pressure-lowering capability in patients with acute neurological injury (hemorrhage, stroke, and subarachnoid and acute intracerebral hemorrhage), those  undergoing coronary artery bypass graft or spinal surgery, and in those with cerebral aneurysm/pheochromocytoma, acute heart failure, acute aortic syndromes, or renal insufficiency with severe hypertension, and it is equivalent to commonly used blood pressure-lowering medicines such as nicardipine or nitroglycerin. "
5.	Sulfhydryl Compounds (Thiols)IBA 01/01/2018 - "The aim of this study was to evaluate whether ranging values of thiol and disulphide herald a dilatation or impending acute aortic syndrome at thoracic aorta. " 01/01/2018 - "Thiol/disulphide homeostasis in thoracic aortic aneurysm and acute aortic syndrome."
6.	Nicardipine (Dagan)FDA LinkGeneric 03/01/2022 - "In recent years, clinical trials have shown that clevidipine has excellent blood pressure-lowering capability in patients with acute neurological injury (hemorrhage, stroke, and subarachnoid and acute intracerebral hemorrhage), those  undergoing coronary artery bypass graft or spinal surgery, and in those with cerebral aneurysm/pheochromocytoma, acute heart failure, acute aortic syndromes, or renal insufficiency with severe hypertension, and it is equivalent to commonly used blood pressure-lowering medicines such as nicardipine or nitroglycerin. "
7.	Nitroglycerin (Dynamite)FDA LinkGeneric 03/01/2022 - "In recent years, clinical trials have shown that clevidipine has excellent blood pressure-lowering capability in patients with acute neurological injury (hemorrhage, stroke, and subarachnoid and acute intracerebral hemorrhage), those  undergoing coronary artery bypass graft or spinal surgery, and in those with cerebral aneurysm/pheochromocytoma, acute heart failure, acute aortic syndromes, or renal insufficiency with severe hypertension, and it is equivalent to commonly used blood pressure-lowering medicines such as nicardipine or nitroglycerin. "
8.	C-Reactive ProteinIBA 01/01/2010 - "The purpose of this study was to determine whether high-sensitivity C-reactive protein (hsCRP) levels differ among patients with acute aortic syndromes (AAS) and if hsCRP could predict their long-term outcomes. " 01/01/2010 - "Predictive value of high sensitivity C-reactive protein in the diagnosis and outcomes of acute aortic syndromes."
9.	TroponinIBA 01/01/2023 - "Blood-test-based methods of distinguishing between acute aortic syndromes (AASs) and non-ST-elevation myocardial infarction (NSTEMI) during the troponin-blind period of <2-3 h of symptom onset have not been studied previously. " 01/01/2023 - "Development and validation of nomogram models to discriminate between acute aortic syndromes and non-ST-elevation myocardial infarction during troponin-blind period." 11/01/2016 - "Despite troponin assay being a part of the diagnostic work up in many conditions with acute chest pain, little is known about its frequency and clinical implications in acute aortic syndromes (AASs). " 03/01/2011 - "The clinical scenario (medical history of hypertension, severe substernal chest pain, early diastolic decrescendo murmur as for aortic insufficiency), the laboratory results (no significant troponin level), ECG and transthoracic echocardiography findings (no signs of myocardial ischemia) shifted the initial diagnostic suspicion from acute coronary syndrome to the acute aortic syndrome (AAS) and triggered further imaging tests. " 04/22/2023 - "The D-Dimer to Troponin Ratio Is a Novel Marker for the Differential Diagnosis of Thoracic Acute Aortic Syndrome from Non-ST Elevation Myocardial Infarction."
10.	Immunoglobulin G (IgG)IBA 12/01/2016 - "The great imitator: IgG4 periaortitis masquerading as an acute aortic syndrome on computed tomographic angiography." 05/01/2021 - "IgG4 aortitis is a recently recognized entity that can have clinical and imaging features that mimic acute aortic syndrome. "

Therapies and Procedures

1.	Endovascular Aneurysm Repair 12/01/2014 - "The objective of this study was to evaluate the safety and efficacy of TEVAR during the in-hospital period and at mid-term follow-up, and compare with medical and surgical treatment in patients who presented with acute aortic syndrome (AAS) type B. " 11/15/2023 - " Background: The aim of this study was to explore the impact of post-implantation syndrome (PIS) on prognosis outcomes in individuals with type B acute aortic syndrome (AAS) undergoing thoracic endovascular aortic repair (TEVAR). " 01/01/2021 - "Methods: A total of 129 ATBAD patients in the National Acute Aortic Syndrome Database (AASCN) who underwent TEVAR between 2019 and 2020 were enrolled in our study. " 12/01/2023 - "Acting as minimally invasive alternatives, both techniques are feasible for left subclavian artery preservation during zone 2 thoracic endovascular aortic repair for type B acute aortic syndromes with encouraging mid-term outcomes. " 10/16/2023 - " A total of 52 patients with acute aortic syndromes underwent TEVAR (March 2017 to May 2021) requiring proximal landing in the distal aortic arch. "
2.	Emergency Treatment 05/01/2002 - "Endovascular treatment is safe and effective for emergency treatment of life-threatening complications in selected acute aortic syndromes. " 01/01/2021 - "The aim of this study was to establish if patients affected by acute aortic syndrome (AAS) had unrestricted access to emergency treatment and evaluate outcome of these patients during the peak of the pandemic. " 03/01/2021 - "This study assessed access to emergency treatment, logistical challenges, and outcomes of patients with acute aortic syndrome during the early months of the COVID-19 pandemic in the United Kingdom. "
3.	Therapeutics 04/01/2017 - "Advances in medical therapy and non-surgical percutaneous options to manage the specter of acute aortic syndromes have improved both patient morbidity and mortality. " 06/01/2023 - "Antithrombotic therapy might be associated with an increased risk of aorta-related events in patients with type B acute aortic syndrome." 06/01/2023 - "We reviewed 406 patients with type B acute aortic syndrome who were discharged alive with and without antithrombotic therapy. " 06/01/2023 - "We aimed to explore the association of antithrombotic therapy with the prognosis of patients with type B acute aortic syndrome. " 06/01/2023 - "Impact of antithrombotic therapy on clinical outcomes in patients with type B acute aortic syndrome."
4.	Ligation 06/01/2009 - "Retrograde coil embolization of the LSA, as alternative to open subclavian ligature, is a safe and effective method of rapid false lumen sealing in patients requiring coverage of the LSA and carotid-subclavian bypass, even in the setting of acute aortic syndromes."
5.	Stents 08/24/2022 - "This study reports the outcomes from a Multicenter Registry on unibody stent-graft system for the treatment of spontaneous infrarenal acute aortic syndrome (MURUSSIAS registry). " 08/24/2022 - "Outcome Analysis From a Multicenter Registry on Unibody Stent-Graft System for the Treatment of Spontaneous Infrarenal Acute Aortic Syndrome (MURUSSIAS Registry)." 12/01/2020 - "Endovascular Treatment of Spontaneous and Isolated Infrarenal Acute Aortic Syndrome with Unibody Aortic Stent-Grafts." 06/01/2018 - "Hemodynamic changes lead to alterations in aortic diameters and may challenge further stent graft sizing in acute aortic syndrome." 04/01/2016 - "Inflammatory response following stent grafting for acute aortic syndrome."