Artesunate

A water-soluble, semi-synthetic derivative of the sesquiterpene lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities

Also Known As:

Dihydroartemisinine-12-alpha-succinate; Malacef; Malartin; SM 804; SM-804; Sodium Artesunate; Succinyl Dihydroartemisinin; Dihydroartemisinin, Succinyl; Dihydroartemisinine 12 alpha succinate; SM804; Butanedioic acid, mono((5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester

Networked: 2069 relevant articles (416 outcomes, 527 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	White, Nicholas J: 86 articles (01/2022 - 03/2002)
2.	Efferth, Thomas: 52 articles (07/2022 - 03/2002)
3.	Dondorp, Arjen M: 31 articles (01/2022 - 07/2007)
4.	Nosten, François: 29 articles (10/2021 - 12/2002)
5.	Ringwald, Pascal: 27 articles (05/2022 - 06/2004)
6.	Tarning, Joel: 26 articles (08/2021 - 07/2009)
7.	Looareesuwan, Sornchai: 24 articles (07/2010 - 03/2002)
8.	Krishna, Sanjeev: 23 articles (01/2021 - 12/2002)
9.	Stepniewska, Kasia: 23 articles (01/2020 - 01/2004)
10.	Kremsner, Peter G: 23 articles (12/2019 - 11/2002)

Related Diseases

1.	Malaria 01/01/2017 - "Intravenous artesunate is highly effective in severe knowlesi malaria and in those with moderately high parasitaemia but otherwise uncomplicated disease. " 05/01/2015 - "Artesunate is the most effective treatment for severe malaria. " 02/01/2013 - "Early referral and treatment with artesunate was highly effective for severe malaria from all species and associated with zero mortality." 02/01/2007 - "Our findings indicate that artesunate, in addition to being a very effective treatment for uncomplicated malaria, can also sharply reduce the S. " 10/01/2019 - "Based on strong studies conducted in Asia and Africa, WHO (World Health Organization) has recommended the use of artesunate as a first-line treatment for severe malaria in adults and children since 2010.The use of artesunate has shown a reduction in mortality rate in severe malaria. "
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 03/01/1998 - "Oral artesunate is the most effective treatment for uncomplicated hyperparasitaemia in falciparum malaria. " 01/01/1994 - "Artesunate has been shown to be effective against falciparum malaria, but is associated with a high recrudescence rate. " 03/01/2013 - "IV artesunate is now recommended as the first-line treatment for severe falciparum malaria in France." 03/27/2012 - "Intravenous (i.v.) artesunate is now the recommended first-line treatment of severe falciparum malaria in adults and children by WHO guidelines. " 03/01/2007 - "Rectal artesunate has been shown to be an effective treatment for falciparum malaria and is useful in patients who cannot take medicine orally or when parenteral medication is inconvenient. "
3.	Infections 01/01/2020 - "A highly potent trimeric derivative of artesunate shows promising treatment profiles in experimental models for congenital HCMV infection in vitro and ex vivo." 09/01/2010 - "Artesunate previously showed a high prophylactic efficacy against schistosome infection, with a protection rate of 100%. " 11/01/2002 - "Evidence for the efficacy of artesunate in asymptomatic Plasmodium malariae infections." 01/01/2019 - "Our model recovered the clinical outcomes of existing studies (based on circulating parasites) and showed a "simplified" artesunate regimen was noninferior to the existing World Health Organization regimen across the patient population but resulted in worse outcomes in a subgroup of patients with infections clustered in early stages of the parasite life cycle. " 03/01/2015 - "falciparum infections from artesunate efficacy trials in Bangladesh, Cambodia, Laos, Myanmar, and Vietnam were genotyped at 33 716 genome-wide single-nucleotide polymorphisms (SNPs). "
4.	Parasitemia 01/01/2013 - "Co-primary endpoints included parasite clearance time (the time required for complete clearance of initial parasitemia), parasite clearance half-life (the time required for parasitemia to decrease by 50% based on the linear portion of the parasite clearance slope), and detectable parasitemia 72 hours after commencement of artesunate treatment. " 12/01/2017 - "Thus, we propose that in vivo artesunate treatment causes rapid decline in parasitemia by arresting parasite maturation and encouraging phagocyte-mediated clearance of parasitised RBCs." 12/01/2018 - "Parasitemia was cleared with artesunate (2.4 mg/kg) under a desensitization protocol. " 07/01/2019 - "Similarly, preclinical In vivo studies also signified a radical reduction in parasitemia with ~8-10-fold reduced dosage of artesunate when fortified with iron oxide nanoparticles. " 11/01/2012 - "The overall parasite clearance times were prolonged compared with the clearance times in a previous study at this site in 2006 to 2007, but this did not persist when the evaluation was limited to subjects with a comparable artesunate dose (4 mg/kg/day) and baseline parasitemia from the two studies. "
5.	Neoplasms (Cancer) 05/01/2013 - "Artesunate produced a long-lasting complete remission in one case of cancer and short-term stabilization of another seven cases." 11/01/2023 - "Safety and efficacy of topical artesunate for the treatment of vulvar intraepithelial neoplasia 2/3." 01/02/2019 - "Artesunate (ART) has been reported to improve the cytotoxicity of some chemotherapeutic drugs in cancers. " 01/01/2023 - "Methods: In this study, we focused on the targeting of Hsp90 by artesunate to inhibit tumor cell proliferation, which we examined using immunoprecipitation, a proliferation assay, flow cytometry, western blotting, a tumor xenograft animal model, and immunohistochemistry. " 04/01/2021 - "In this study, we investigated the effects of artesunate on lysosomal function and its relationship with chemotherapeutic drug resistance in cancer cells. "

Related Drugs and Biologics

1.	Amodiaquine (Camoquin)
2.	Mefloquine (Lariam)
3.	Lumefantrine Drug Combination Artemether (Coartem)
4.	pyrimethamine drug combination fanasil (Fansidar)
5.	artemisinin (artemisinine)
6.	Antimalarials (Antimalarial Agents)
7.	Quinine (Quinson)
8.	Chloroquine (Aralen)
9.	Artemether
10.	piperaquine

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration
4.	Ligation
5.	Injections