Crystal Arthropathies

Joint disorders that are characterized by accumulation of microcrystals in and around the joint including in the SYNOVIAL FLUID. They are classified according to the chemical nature of the crystals such as CALCIUM PYROPHOSPHATE; basic CALCIUM PHOSPHATES; and monosodium urate (see URIC ACID).

Also Known As:

Crystal Arthritis; Crystalline Arthritis; Crystalline Arthropathies; Arthritides, Crystal; Arthritides, Crystalline; Arthritis, Crystal; Arthritis, Crystalline; Arthropathies, Crystal; Arthropathies, Crystalline; Arthropathy, Crystal; Arthropathy, Crystalline; Crystal Arthritides; Crystal Arthropathy; Crystalline Arthritides; Crystalline Arthropathy

Networked: 176 relevant articles (6 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 719
- Joint Diseases: 6509
  - Crystal Arthropathies: 176

Related Diseases

1.	Gout
2.	Joint Diseases (Joint Disease)
3.	Arthritis (Polyarthritis)
4.	Infectious Arthritis (Septic Arthritis)
5.	Rotator Cuff Tear Arthropathy

Experts

1.	Dalbeth, Nicola: 8 articles (10/2022 - 03/2009)
2.	Tedeschi, Sara K: 8 articles (10/2022 - 01/2020)
3.	Abhishek, Abhishek: 7 articles (10/2022 - 05/2014)
4.	Pascual, Eliseo: 6 articles (10/2022 - 08/2012)
5.	Rosenthal, Ann K: 6 articles (01/2021 - 05/2005)
6.	Solomon, Daniel H: 5 articles (05/2022 - 01/2020)
7.	Doherty, Michael: 4 articles (10/2022 - 05/2014)
8.	Pascart, Tristan: 4 articles (10/2022 - 01/2021)
9.	Singh, Jasvinder A: 4 articles (10/2022 - 01/2020)
10.	Sivera, Francisca: 4 articles (10/2022 - 08/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Crystal Arthropathies:

1.	Calcium PyrophosphateIBA 06/20/2023 - "Acute Calcium Pyrophosphate Crystal Arthritis is Associated with an Increased Rate of Hip and Knee Joint Surgery." 01/01/2023 - "Calcium pyrophosphate deposition (CPPD) disease represents a common crystalline arthritis with a range of manifestations. " 01/01/2023 - "Confirming Prior and Identifying Novel Correlates of Acute Calcium Pyrophosphate Crystal Arthritis." 10/01/2022 - "Classification criteria for calcium pyrophosphate deposition (CPPD) disease will facilitate clinical research on this common crystalline arthritis. " 05/25/2022 - "Risk of cardiovascular events in patients having had acute calcium pyrophosphate crystal arthritis."
2.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 06/20/2023 - "No studies have specifically examined whether acute CPP crystal arthritis is associated with progressive structural joint damage. " 01/01/2023 - "This is the first study to report higher odds for acute CPP crystal arthritis among males." 01/01/2020 - "Most studies reported clinical presentations of OA with CPPD or acute CPP crystal arthritis. " 06/20/2023 - "The acute CPP crystal arthritis cohort included 99 patients, 63 were male and the median age was 77 years (interquartile range, 71-82). " 06/20/2023 - "Data were collected from Waikato District Health Board (WDHB) to identify an acute CPP crystal arthritis cohort with clinical episodes highly characteristic of acute CPP crystal arthritis. "
3.	Uric Acid (Urate)IBA 01/01/2020 - "'Urate crystal arthritis' was seen as having a wider range of factors responsible for the illness, including stress or worry, hereditary factors and chance. " 11/01/2009 - "A cohort of 248 patients with a diagnosis of urate crystal arthropathy was studied, sent with a definite clinical evaluation, and data such as severity of the disease, joint distribution and the presence of tophi were gathered. " 01/01/1996 - "Anti-inflammatory effect of a PAF receptor antagonist and a new molecule with antiproteinase activity in an experimental model of acute urate crystal arthritis." 01/01/2018 - "In this study we investigated the effect of renaming gout as urate crystal arthritis on the perceptions of the illness. " 05/06/2022 - "Intraoperatively obtained synovial fluid showed monosodium urate crystals consistent with crystalline arthropathy (ie, gout). "
4.	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 10/01/2023 - "Rheumatology was consulted and empirically treated; the patient with a dose of Anakinra due to concerns about a polyarticular flare of crystalline arthropathy. " 06/01/2022 - "Factors Affecting Response to Anakinra in Crystalline Arthritis Flares." 12/01/2012 - "Efficacy of anakinra for refractory acute calcium pyrophosphate crystal arthritis." 10/01/2021 - "Comment on: "Anakinra compared to prednisone in the treatment of acute CPPD crystal arthritis: A randomized controlled double-blinded pilot study" by Dumusc A. " 01/01/2021 - "Anakinra compared to prednisone in the treatment of acute CPPD crystal arthritis: A randomized controlled double-blinded pilot study."
5.	alpha-DefensinsIBA 06/01/2021 - "This case raises the possibility that patients with periprosthetic crystal arthropathy and a positive alpha-defensin test can be managed nonoperatively in the appropriate setting." 01/01/2021 - "We tested the ability of an alpha-defensin test to distinguish septic from inflammatory or crystalline arthropathy in the native knee. " 01/01/2020 - "In this case, we conclude that patients with a negative alpha-defensin assay alongside crystalline arthropathy on histology may be cautiously yet successfully treated non-operatively despite clinical MSIS criteria concerning for PJI." 01/01/2021 - "We determined the sensitivity and specificity of the alpha-defensin test using culture-positive fluid as the gold standard for septic arthropathy and positive crystals as the gold standard for crystalline arthropathy. "
6.	Febuxostat FDA Link 01/01/2018 - "Crystal arthritis: Stepping up febuxostat to treat gout flares." 12/01/2017 - "Crystal arthritis: Febuxostat reduces synovitis in early gout." 11/08/2019 - "For patients with recurrent flares of gout, tophi, urate crystal arthropathy, and renal stones, urate-lowering therapies (ULTs, including allopurinol and febuxostat) are the first-line treatment. "
7.	Allopurinol (Remid)FDA LinkGeneric 01/01/2011 - "Crystal arthritis: 'Treat-to-target' with allopurinol is feasible in patients with gout." 11/08/2019 - "For patients with recurrent flares of gout, tophi, urate crystal arthropathy, and renal stones, urate-lowering therapies (ULTs, including allopurinol and febuxostat) are the first-line treatment. "
8.	Adrenocorticotropic Hormone (ACTH)FDA Link 01/01/2014 - "ACTH as first line treatment for acute calcium pyrophosphate crystal arthritis in 14 hospitalized patients."
9.	calcium phosphateIBA 10/01/1984 - "Histopathological and ultrastructural studies of synovium in Milwaukee shoulder syndrome--a basic calcium phosphate crystal arthropathy." 01/01/2014 - "Milwaukee shoulder syndrome (MSS) is a rare destructive, calcium phosphate crystalline arthropathy. " 03/01/2007 - "Recent literature concerning clinical and etiologic aspects of calcium pyrophosphate dihydrate and basic calcium phosphate crystal arthritis are reviewed. " 04/01/2004 - "The relevance of these findings to CaP and CaPPi in the pathogenesis of crystal arthropathies such as basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate crystal disease (CPPD) is discussed." 09/01/2017 - "Conventional Radiology in Crystal Arthritis: Gout, Calcium Pyrophosphate Deposition, and Basic Calcium Phosphate Crystals."
10.	CalciumIBA 05/01/2005 - "Histologic studies of cartilage from patients affected by calcium crystal arthritis show changes in the pericellular matrix of articular chondrocytes. " 11/01/2008 - "Our results suggest a new pathophysiological mechanism for calcium-containing crystal arthropathies." 05/01/2014 - "Calcium crystal arthritis is often unrecognized, poorly managed, and few effective therapies are available. " 01/01/1984 - "[Calcium crystal arthritis (pseudogout, chondrocalcinosis)]." 10/17/2013 - "Understanding the mechanisms of eATP efflux may result in novel therapies for calcium crystal arthritis and osteoarthritis."

Therapies and Procedures

1.	Therapeutics 09/01/2006 - "Anti-tuberculous therapy-induced crystal arthropathy." 01/01/2017 - "Crystal arthritis: Combination therapy effective in tophaceous gout." 05/01/2014 - "Both ultrasonography and MRI reveal features of inflammation and joint damage in all crystal arthropathies, and can be used to monitor the inflammatory response to therapy. " 03/01/2016 - "Current advances in therapies for calcium pyrophosphate crystal arthritis." 05/01/2014 - "Calcium crystal arthritis is often unrecognized, poorly managed, and few effective therapies are available. "
2.	Arthroplasty 05/01/2022 - "Of these cases, 25 presented over 1 year after their index arthroplasty and 15 had no prior history of crystalline arthropathy. " 01/01/2020 - "Orthopedic surgeons should be aware of the potential for crystal arthropathy in the setting of total joint arthroplasty and evaluate for crystals before treating a presumed periprosthetic joint infection." 06/20/2023 - "Our study identified a considerable increase in the rate of hip and knee joint arthroplasties in patients with episodes of acute CPP crystal arthritis. " 06/20/2023 - "The objective of this retrospective cohort study was to evaluate the relative rate of hip and knee joint arthroplasties as an estimate of structural joint damage accrual, in a population of patients with acute CPP crystal arthritis. " 03/01/2017 - "Adverse reaction to metal debris with concomitant incidental crystalline arthropathy in hip arthroplasty."
3.	Knee Replacement Arthroplasty (Total Knee Replacement) 05/01/2022 - "We sought to systematically review all cases of total knee arthroplasty (TKA) periprosthetic crystalline arthropathy reported in the literature and summarize clinical, diagnostic, and operative findings in the context of guidelines for diagnosing PJI. " 06/01/2020 - "Crystalline arthropathies are well-known pathologies in a native knee; however, the literature is scarce with regards to crystalline arthropathies in a total knee arthroplasty (TKA). " 01/01/2020 - "Crystal Arthropathy in the Setting of Total Knee Arthroplasty." 05/06/2022 - "Acute haematogenous periprosthetic joint infection due to Streptococcus sanguinis along with coexistent crystalline arthropathy after total knee arthroplasty: a rare combination." 05/01/2022 - "Distinguishing Periprosthetic Crystalline Arthropathy from Infection in Total Knee Arthroplasty: A Systematic Review."
4.	Renal Dialysis (Hemodialysis) 07/01/2008 - "The management of acute and chronic crystalline arthropathies in chronic kidney disease and hemodialysis patients is discussed." 02/01/1988 - "In addition to crystal arthropathies and the more common infectious arthritides, one should be aware of arthritides with opportunistic microorganisms in immune compromised hemodialysis patients."
5.	Drug Therapy (Chemotherapy) 10/01/2022 - "Gout is the most prevalent inflammatory crystal arthropathy worldwide and is a chronic disease requiring strict, lifelong adherence to drug therapy and healthy lifestyles. " 03/01/2019 - "Use of proton pump inhibitors (PPIs) [hazard ratio (HR), 5.625; 95% CI, 1.672-18.925; p=0.005] and warfarin (HR, 7.301; 95% CI, 1.930-27.622; p=0.003) or exposure to chemotherapy (HR, 5.663; 95% CI, 1.180-27.169; p=0.03) were associated with acute CPP crystal arthritis recurrence. "