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6- ((3- ((4- (5- ((2- hydroxy- 2- (8- hydroxy- 2- oxo- 1,2- dihydroquinolin- 5- yl)ethyl)amino)pent- 1- yn- 1- yl)phenyl)carbamoyl)phenyl)sulfonyl)- 4- ((3- methoxyphenyl)amino)- 8- methylquinoline- 3- carboxamide

inhibits phosphodiesterase 4, a beta2-adrenoceptor agonist

Also Known As:

GS-5759

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - 6-((3-((4-(5-((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)pent-1-yn-1-yl)phenyl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide: 3
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        6-((3-((4-(5-((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)pent-1-yn-1-yl)phenyl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide: 3

Experts

1.	Kim, Musong: 3 articles (02/2017 - 04/2014)
2.	Phillips, Gary B: 3 articles (02/2017 - 04/2014)
3.	Salmon, Michael: 3 articles (02/2017 - 04/2014)
4.	Tannheimer, Stacey L: 3 articles (02/2017 - 04/2014)
5.	Wright, Clifford D: 3 articles (02/2017 - 04/2014)
6.	Baker, William R: 2 articles (08/2014 - 04/2014)
7.	Cui, Zhi-Hua: 2 articles (08/2014 - 04/2014)
8.	Sorensen, Eric A: 2 articles (08/2014 - 04/2014)
9.	Giembycz, Mark A: 1 article (02/2017)
10.	Hamed, Omar: 1 article (02/2017)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 02/01/2017 - "GS-5759, a Bifunctional β2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells." 08/01/2014 - "GS-5759 is a bifunctional molecule developed for the treatment of COPD, which has both bronchodilator and anti-inflammatory activity and has the potential for combination as a triple therapy with a second compound, within a single inhalation device. " 04/01/2014 - "GS-5759 is a novel bifunctional molecule with both potent β(2) agonist and PDE4 inhibitor activity that could provide inhaled bronchodilator and anti-inflammatory therapy for COPD."
2.	Inflammation (Inflammations) 08/01/2014 - "GS-5759 dose-dependently inhibited pulmonary neutrophilia in a lipopolysaccharide (LPS) aerosol challenge model of inflammation in rats with an ED50 ≤ 10 μg/kg. GS-5759 was also a potent bronchodilator with an ED50 of 0.09 μg/kg in guinea pigs and 3.4 μg/kg in dogs after methylcholine (MCh) and ragweed challenges respectively. "

Related Drugs and Biologics

1.	Phosphodiesterase 4 Inhibitors
2.	Bronchodilator Agents (Bronchodilators)
3.	Lipopolysaccharides
4.	Aerosols
5.	methylcholine

Related Therapies and Procedures

1.	Therapeutics
2.	Nebulizers and Vaporizers (Inhaler)