polyphyllin VII

01/01/2020 - "The present study was designed to investigate the underlying mechanisms of the antitumor effect of Polyphyllin VII in lung cancer cells. "
01/01/2023 - "We observed that polyphyllin VII had significant cytotoxicity and inhibited colony formation, migration, and invasion in both our newly established cell line CTC-TJH-01 and a commercial lung cancer cell line H1975. "
01/01/2020 - "The present results revealed that Polyphyllin VII was able to induce apoptotic cell death in A549 human lung cancer cells via inhibition of the PI3K/Akt and NF‑κB pathways."
01/01/2020 - "The cytotoxic effect of Polyphyllin VII in human lung cancer A549 cells was analyzed; the results revealed an IC50 value of 0.41±0.10 µM at 24 h. "
01/01/2020 - "Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells."

01/01/2021 - "One of the new plants derived compounds is Polyphyllin VII (PPVII), which target cancer through different molecular mechanisms. "
01/01/2018 - "However the IC50 of Polyphyllin G was found to be comparatively high (120 μM) against the normal FR2 cancer cell line. "
01/01/2018 - "Further Polyphyllin G was also evaluated against a panel of cancer cell lines. "
10/01/2015 - "Polyphyllin VI (PVI) and polyphyllin VII (PVII) derived from Paris polyphylla possess anti-cancer activities. "
10/25/2016 - "In conclusion, our results reveal that Polyphyllin G inhibits cell viability and induces apoptosis and autophagy in NPC cancer cells, suggesting that Polyphyllin G is an attractive candidate for tumor therapies. "

01/01/2023 - "In this study, we present evidence that polyphyllin VII, a potent anticancer compound, effectively inhibits the metastasis of lung cancer by inducing a process called anoikis in CTCs. "
01/01/2023 - "Together, these results suggest that polyphyllin VII may be a promising compound for the treatment of lung cancer metastasis by targeting CTCs."
01/01/2023 - "Polyphyllin VII induces CTC anoikis to inhibit lung cancer metastasis through EGFR pathway regulation."
05/31/2021 - "Anti-angiogenesis and anti-metastasis effects of Polyphyllin VII on Hepatocellular carcinoma cells in vitro and in vivo."
01/01/2023 - "Furthermore, our immunodeficient mouse models recapitulated that polyphyllin VII inhibited lung metastasis, which was associated with downregulation of the EGFR protein, and reduced the number of CTCs disseminated into the lungs by inducing anoikis. "

12/01/2016 - "This study is the first to demonstrate apoptosis and autophagy during polyphyllin G-induced cell death in human oral cancer cell lines. "
12/01/2016 - "In this study, the roles of apoptosis and autophagy in polyphyllin G-induced death in human oral cancer cells were investigated. "
01/01/2018 - "Therefore, we propose that Polyphyllin G might prove a lead molecule in the management of oral cancers and at the same time may prevent the growth of opportunistic microbes."
01/01/2018 - "Our results indicated that Polyphyllin G induced cell arrest in oral cancer OECM-1 cells by inactivation of cdc25C-cdc22 via ATM-Chk 1/2 stimulation. "
01/01/2018 - "Polyphyllin G exhibits antimicrobial activity and exerts anticancer effects on human oral cancer OECM-1 cells by triggering G2/M cell cycle arrest by inactivating cdc25C-cdc2."

02/09/2016 - "In the present study, the anticancer effect of polyphyllin VII against human liver cancer cells and the molecular mechanisms were investigated. "
01/01/2023 - "Polyphyllin VII as a Potential Drug for Targeting Stemness in Hepatocellular Cancer via STAT3 Signaling."