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N- (2- (1H- indazol- 3- yl)- 1H- pyrrole(3,2- b)pyridin- 5- yl)- 4- chloro- N- methylbenzamide

an antineoplastic agent; structure in first source

Also Known As:

SMT A07; SMT-A07

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cao, Ji: 1 article (12/2010)
2.	He, Qiaojun: 1 article (12/2010)
3.	Hu, Yongzhou: 1 article (12/2010)
4.	Qian, Shijing: 1 article (12/2010)
5.	Sun, Maotang: 1 article (12/2010)
6.	Yan, Yan: 1 article (12/2010)
7.	Yang, Bo: 1 article (12/2010)
8.	Zhu, Hong: 1 article (12/2010)

Related Diseases

1.

12/01/2010 - "The anticancer activities in vitro and the cell apoptosis-induction abilities of SMT-A07 on human leukemia HL60 and NB4 cell lines were investigated in this study. "
12/01/2010 - "The results of MTT assay showed SMT-A07 was a potential and highly efficient antitumor compound with IC(50) values ranging from 0.09 to 1.19 μM in five leukemia cell lines. "
12/01/2010 - "Our study demonstrates that SMT-A07 displays an apparent antitumor activity with extensive anti-leukemia spectrum, and SMT-A07 can induce the apoptosis of HL60 and NB4 cells activation of the caspase cascade, which deserves further development."
12/01/2010 - "SMT-A07, a 3-(Indol-2-yl) indazole derivative, induces apoptosis of leukemia cells in vitro."

Related Drugs and Biologics

1.	Caspases
2.	Indazoles