N'- ((1E)- 1- (3,4- dimethoxyphenyl)ethylidene)- 3- (4- methoxyphenyl)- 1H- pyrazole- 5- carbohydrazide

07/01/2017 - "SKI-178 is safe and effective in mouse models of AML, supporting its further development as a multi-targeted anti-cancer therapeutic agent."

03/01/2015 - "Using human acute myeloid leukemia (AML) cell lines as a model, we present evidence that SKI-178 induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. "
03/01/2015 - "The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines."

01/01/2023 - "Together, targeting SphK1/2 by SKI-178 potently inhibited prostate cancer cell growth in vitro and in vivo."
01/01/2023 - "Further, SKI-178 inhibited Akt-mTOR activation and induced JNK activation in prostate cancer cells. "
01/01/2023 - "In primary human prostate cancer cells and immortalized cell lines, SKI-178 potently inhibited cell viability, proliferation, cell cycle progression and cell migration, causing robust cell death and apoptosis. "
01/01/2023 - "We here tested the potential anti-prostate cancer cell activity of SKI-178. "
01/01/2023 - "Targeting SphK1/2 by SKI-178 inhibits prostate cancer cell growth."

01/01/2015 - "SKI-II and SKI-178 also induced apoptosis in primary NK-LGLs from leukemia patients. "