xanthoxyline

isolated from Sebastiania schottiana (Euphorbiaceae); structure given in first source; also present in Xanthoxylum, Rutaceae, Artemisia and other plants

Also Known As:

2-hydroxy-4,6-dimethoxyacetophenone; brevifolin; xanthoxylin; Ethanone, 1-(2-hydroxy-4,6-dimethoxyphenyl)-

Networked: 8 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 140
- Ketones: 2712
  - Acetophenones: 17
    - xanthoxyline: 8

Experts

1.	Bezerra, Daniel P: 2 articles (12/2023 - 01/2018)
2.	Carlos, Rose M: 2 articles (12/2023 - 01/2018)
3.	Dias, Rosane B: 2 articles (12/2023 - 01/2018)
4.	Dos Santos, Edjane R: 2 articles (12/2023 - 01/2018)
5.	Nogueira, Paulo C L: 2 articles (12/2023 - 01/2018)
6.	Oliveira, Regina M M: 2 articles (12/2023 - 01/2018)
7.	Rocha, Clarissa A G: 2 articles (12/2023 - 01/2018)
8.	Soares, Milena B P: 2 articles (12/2023 - 01/2018)
9.	Valverde, Ludmila de F: 2 articles (12/2023 - 01/2018)
10.	Chen, Guilin: 1 article (05/2024)

Related Diseases

1.	Wounds and Injuries (Trauma) 09/01/2006 - "Brevifolin and 8,9-single-epoxy brevifolin show protective effective against acute and chronic liver injuries, and the mechanism is relevant to antagonizing the lipid peroxidation of free radical and improving the blood circulation."
2.	Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia) 07/17/2023 - "Twenty-six chemical compounds were identified in CpEO, elemicin, bicyclogermacrene, caryophyllene, brevifolin, and 2,4,6-trimethoxy-styrene. "
3.	Colorectal Neoplasms (Colorectal Cancer) 12/15/2023 - "In this work, we describe a novel ruthenium-xanthoxylin complex, [Ru(phen)2(xant)](PF6) (RXC), that can eliminate colorectal cancer (CRC) stem cells by targeting the chaperone Hsp90. " 12/15/2023 - "New ruthenium-xanthoxylin complex eliminates colorectal cancer stem cells by targeting the heat shock protein 90 chaperone."
4.	Chagas Disease (American Trypanosomiasis) 10/15/2009 - "In the search of molecules that can serve as leads in the design of a new drug for the treatment of Chagas' disease, we found that some brevifolin carboxylate derivatives isolated from Geranium bellum Rose, inactivate triosephosphate isomerase from Trypanosoma cruzi (TcTIM) in a species-specific manner. "
5.	Parasitic Diseases (Parasitic Disease) 05/17/2024 - "At the same time, corilagin, brevifolin carboxylic acid, brevifolin, quercetin, methyl ellagic acid, and methyl brevifolin carboxylate exert their anti-parasitic effects by inhibiting AChE, LDH, and GR, and they are expected to be natural lead compounds for the treatment of parasitic diseases."

Related Drugs and Biologics

1.	Free Radicals
2.	8,9-single-epoxy brevifolin
3.	Ruthenium
4.	Quercetin
5.	Ellagic Acid
6.	Carboxylic Acids
7.	Polyphenols
8.	Glucuronides
9.	Interleukin-6 (Interleukin 6)
10.	Triose-Phosphate Isomerase (Triosephosphate Isomerase)