Triose-Phosphate Isomerase (Triosephosphate Isomerase)

An enzyme that catalyzes reversibly the conversion of D-glyceraldehyde 3-phosphate to dihydroxyacetone phosphate. A deficiency in humans causes nonspherocytic hemolytic disease (ANEMIA, HEMOLYTIC, CONGENITAL NONSPHEROCYTIC). EC 5.3.1.1.

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Networked: 151 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Aguirre-López, Beatriz: 3 articles (04/2014 - 10/2009)
2.	Pérez-Montfort, Ruy: 3 articles (04/2014 - 07/2002)
3.	Xiao, Lihua: 3 articles (10/2013 - 11/2003)
4.	Mariuzza, Roy A: 3 articles (09/2012 - 05/2002)
5.	Kuramitsu, Yasuhiro: 3 articles (01/2012 - 08/2005)
6.	Nakamura, Kazuyuki: 3 articles (01/2012 - 08/2005)
7.	Cerecetto, Hugo: 2 articles (04/2014 - 10/2013)
8.	González, Mercedes: 2 articles (04/2014 - 10/2013)
9.	Gómez-Puyou, Armando: 2 articles (04/2014 - 07/2002)
10.	Cabrera, Nallely: 2 articles (04/2014 - 10/2013)

Related Diseases

1.	Hemolytic Anemia 08/01/2014 - "Hemolytic anemia and progressive neurologic impairment: think about triosephosphate isomerase deficiency." 03/01/2013 - "Mild hemolytic anemia, progressive neuromotor retardation and fatal outcome: a disorder of glycolysis, triose- phosphate isomerase deficiency." 11/01/1986 - "[A case of congenital non-spherocytic hemolytic anemia caused by triose phosphate isomerase deficiency. " 09/01/1982 - "A 12-year-old girl had chronic nonspherocytic hemolytic anemia due to triosephosphate isomerase deficiency. " 06/09/1978 - "Triosephosphate isomerase deficiency with hemolytic anemia and severe neuromuscular disease: familial and biochemical studies of a case found in Spain."
2.	Shock 03/23/2012 - "The Giardia assemblages were determined using the glutamate dehydrogenase (GDH) β-giardin and triose phosphate isomerase (TPI) genes and the Cryptosporidium species were determined using the heat shock protein-70 gene. " 02/16/2001 - "Out of these, specific regulations of 14 spots were found by quantitative image analysis and spots of interest were identified with MALDI TOF-MS. The regulated and identified proteins were triosephosphate isomerase, cofilin and heat shock 27-kDa protein." 08/01/2009 - "The relative spot intensity of several glycolytic enzymes was significantly greater in the grazing group, such as beta-enolase 3, fructose-1,6-bisphosphate aldolase A, triosephosphate isomerase, and heat shock 27 kDa protein (P < 0.05). " 07/01/2006 - "Proteins that were frequently modified and had the highest molar content of HNE included triosephosphate isomerase, alpha enolase, heat shock cognate 70 and betaB2 crystallin. " 04/01/2008 - "Together, at both the mRNA and protein levels, SAHA suppressed the expression of reticulocalbin 1 precursor (RCN1), annexin A3 (ANXA3) and heat shock 27 kDa protein 1 (HSP27), while increasing the expression of aldose reductase (AR), triosephosphate isomerase 1 (TPI) and manganese superoxide dismutase (SOD2). "
3.	Alzheimer Disease (Alzheimer's Disease) 05/01/2009 - "Transmission electron microscopy (TEM) and atomic force microscopy studies have demonstrated that nitro-triosephosphate isomerase binds tau monomers and induces tau aggregation to form paired helical filaments, the characteristic intracellular hallmark of Alzheimer's disease brains. " 05/10/2013 - "Glycometabolism disorder induced by triose phosphate isomerase (TPI) is closely related to Alzheimer's disease (AD). " 01/01/2013 - "The pathophysiology of triose phosphate isomerase dysfunction in Alzheimer's disease." 05/01/2009 - "Higher levels of nitro-triosephosphate isomerase (P < 0.05) were detected, by Western blot, in immunoprecipitates from hippocampus (9 individuals) and frontal cortex (13 individuals) of Alzheimer's disease patients, compared with healthy subjects (4 and 9 individuals, respectively). " 01/01/2014 - "Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease."
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 07/20/2015 - "Most of these proteins, including peroxiredoxin-6 (PRDX6), triosephosphate isomerase (TPI1), ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1), and annexins A5 (ANXA5) and A7 (ANXA7), may be of significant importance because they were previously identified in proteomic studies in animals treated with psychostimulants and/or because they are related to neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. " 01/01/2012 - "We identified six proteins with altered functional activities in neurodegenerative disease states that were modulated by tianma: triosephosphate isomerase (Tpi1), peptidyl-prolyl cis-trans isomerase A (Ppia), neural cell adhesion molecule 1 (Ncam1), ubiquitin carboxyl-terminal hydrolase isozyme L1 (Uchl1), septin-2 (Sept2) and heat shock protein 90 (Hsp90aa1). "
5.	Parkinson Disease (Parkinson's Disease) 07/20/2015 - "Most of these proteins, including peroxiredoxin-6 (PRDX6), triosephosphate isomerase (TPI1), ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1), and annexins A5 (ANXA5) and A7 (ANXA7), may be of significant importance because they were previously identified in proteomic studies in animals treated with psychostimulants and/or because they are related to neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. "

Related Drugs and Biologics

1.	Enzymes
2.	Phosphopyruvate Hydratase (Enolase)
3.	Fructose-Bisphosphate Aldolase (Aldolase)
4.	Phosphoglycerate Kinase (Kinase, Phosphoglycerate)
5.	Glucose-6-Phosphate Isomerase (Phosphoglucose Isomerase)
6.	Proteins (Proteins, Gene)
7.	Autoantibodies
8.	Glutathione Transferase (Glutathione S-Transferase)
9.	Peroxiredoxin VI
10.	Ubiquitin

Related Therapies and Procedures

1.	Therapeutics
2.	Plasmapheresis