clipsin

chymotrypsin-like protease found in rat brain; irreversibly inhibited by alpha 1-antichymotrypsin; may be involved in the etiology of Down's syndrome & Alzheimer's disease

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 03/05/1990 - "Because independent lines of evidence suggest that a brain chymotrypsin-like protease may be involved in the etiology of Down's syndrome and Alzheimer's disease, clipsin is discussed as a candidate for such a role." 08/31/1992 - "'Clipsin' and other peptide bond hydrolase activities that appear to be integral membrane proteins, including two implicated in the formation of the histological hallmarks of Alzheimer's disease, were assayed in the frontal and parietal cortex from a large (n = 45) series of postmortem human brains. "
2.	Down Syndrome (Down's Syndrome) 03/05/1990 - "Because independent lines of evidence suggest that a brain chymotrypsin-like protease may be involved in the etiology of Down's syndrome and Alzheimer's disease, clipsin is discussed as a candidate for such a role."

Related Drugs and Biologics

1.	Chymases (Chymase)
2.	Peptides (Polypeptides)
3.	Membrane Proteins (Integral Membrane Proteins)
4.	Hydrolases