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obtusaquinone

RN given refers to cpd without isomeric designation; structure given in first source

Also Known As:

obtusaquinone, (E,E)-isomer; 4-cinnamyl-5-methyl-benzene-1,2-diol

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Tannous, Bakhos A: 3 articles (01/2020 - 05/2013)
2.	Badr, Christian E: 2 articles (01/2020 - 05/2013)
3.	Amante, Romain: 1 article (01/2020)
4.	Boukhali, Myriam: 1 article (01/2020)
5.	Chen, John W: 1 article (01/2020)
6.	Chiu, Norman H L: 1 article (01/2020)
7.	Fitzsimons, Evelyn: 1 article (01/2020)
8.	Haas, Wilhelm: 1 article (01/2020)
9.	Kirov, Aleksandar B: 1 article (01/2020)
10.	Lashgari, Ghazal: 1 article (01/2020)

Related Diseases

1.	Delayed Hypersensitivity (Hypersensitivity, Type IV) 01/01/1983 - "Delayed hypersensitivity due to occupational contact with Cocobolo wood and playing the recorders manufactured from this species was proven in three of five patients by positive results in patch tests with its constituents R-4-methoxydalbergione and obtusaquinone. "
2.	Glioblastoma (Glioblastoma Multiforme) 05/01/2013 - "To test the effect of our compound, obtusaquinone (OBT), we used several cell viability assays on seven different glioblastoma (GBM) cell lines and primary cells and on 12 different cell lines representing various cancer types in culture as well as on subcutaneous (n = 7 mice per group) and two intracranial GBM (n = 6-8 mice per group) and breast cancer (n = 6 mice per group) tumor models in vivo. " 01/01/2020 - "We have previously identified the natural product obtusaquinone (OBT) as a potent antineoplastic agent with promising in vivo activity in glioblastoma and breast cancer through the activation of oxidative stress; however, the molecular properties of this compound remained elusive. "
3.	Breast Neoplasms (Breast Cancer) 05/01/2013 - "To test the effect of our compound, obtusaquinone (OBT), we used several cell viability assays on seven different glioblastoma (GBM) cell lines and primary cells and on 12 different cell lines representing various cancer types in culture as well as on subcutaneous (n = 7 mice per group) and two intracranial GBM (n = 6-8 mice per group) and breast cancer (n = 6 mice per group) tumor models in vivo. " 01/01/2020 - "We have previously identified the natural product obtusaquinone (OBT) as a potent antineoplastic agent with promising in vivo activity in glioblastoma and breast cancer through the activation of oxidative stress; however, the molecular properties of this compound remained elusive. "
4.	Neoplasms (Cancer) 05/01/2013 - "Targeting cancer cells with the natural compound obtusaquinone." 05/01/2013 - "To test the effect of our compound, obtusaquinone (OBT), we used several cell viability assays on seven different glioblastoma (GBM) cell lines and primary cells and on 12 different cell lines representing various cancer types in culture as well as on subcutaneous (n = 7 mice per group) and two intracranial GBM (n = 6-8 mice per group) and breast cancer (n = 6 mice per group) tumor models in vivo. "
5.	Hypersensitivity (Allergy) 01/01/1983 - "The biogenetic correlations of these isomeric compounds, the strong epicutaneous reactions in the patients as well as the strong sensitizing capacity of obtusaquinone obtained in guinea pig sensitization experiments corroborate the supposition not to consider the dalbergione but the quinone methide (obtusaquinone) as the inductor of Cocobolo hypersensitivity. "

Related Drugs and Biologics

1.	Antineoplastic Agents (Antineoplastics)
2.	quinone methide