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chloroethylene oxide

postulated metabolite of vinyl chloride; structure

Also Known As:

2-chloroethylene oxide; chlorooxirane

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ethers: 242
  - Cyclic Ethers: 12
    - Epoxy Compounds: 689
      - Ethylene Oxide: 525
        chloroethylene oxide: 3

Experts

1.	Bolognesi, Claudia: 1 article (10/2017)
2.	Bruzzone, Marco: 1 article (10/2017)
3.	Ceppi, Marcello: 1 article (10/2017)
4.	Kirsch-Volders, Micheline: 1 article (10/2017)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2017 - "Following inhalation, the compound is rapidly absorbed and metabolized in the liver to the electrophilic metabolites chloroethylene-oxide and chloroacetaldehyde, which form DNA adducts that can be processed into point mutations in cancer-related genes detected in humans and rats exposed to VC. " 02/01/1980 - "Application to the skin of a single dose of either bis(chloromethyl)ether or chloroethylene oxide, followed by 3-times-weekly applications of 12-O-n-tetradecanoylphorbol-13-acetate for 42 weeks, produced skin tumors in mice; chloroacetaldehyde under comparable conditions produced no increase in benign or malignant tumors. " 02/01/1980 - "administration of chloroethylene oxide, a reactive metabolite of the carcinogen vinyl chloride, induced local tumors in mice, with an incidence comparable to that of bis(chloromethyl)ether, a structurally related human and animal carcinogen, when both compounds were applied at maximum tolerated chronically toxic doses; no tumors distant from the injection site were produced. "
2.	Carcinogenesis 09/06/1976 - "On the basis of these assays a working hypothesis for the vinyl chloride carcinogenesis mechanism is proposed which involves chlorooxirane and chloroacetaldehyde monomer hydrate as the ultimate carcinogenic metabolites of vinyl chloride."

Related Drugs and Biologics

1.	chloroacetaldehyde
2.	Vinyl Chloride (Chloroethylene)
3.	DNA Adducts
4.	Carcinogens
5.	Bis(Chloromethyl) Ether (Chloromethyl Ether)