Epoxy Compounds (Epoxides)

06/01/2001 - "Data from these studies are consistent with in vivo and in vitro metabolism data providing further support for the differences in metabolic activation and deactivation of BD and BD epoxides across species and the role of DEB in tumor development. "
08/30/2012 - "Overall, the dose-dependent effects that were seen allowed us to define a genotoxicity scale for the different epoxides as follows: SO>EB>DEB>IO>PO>BO, which is in partial agreement with the International Agency for Research on Cancer (IARC) classification of the carcinogenic hazards."
04/01/2009 - "Antiproliferative activity of these epoxides revealed that ent-isogoniothalamin oxide (ent-2) was the most active against the eight cancer cell lines studied. "
02/01/2003 - "This is the first report on a comparison of mammary cancer induction by fjord and bay region diol epoxides derived from the same molecule. "
06/01/2001 - "It is metabolized in vivo to reactive epoxides, which might cause the tumors observed in IP exposed rodents. "

11/01/1990 - "The four epoxides selected were among the most mutagenic aliphatic epoxides in our previous structure-mutagenicity studies with the Ames test and had been evaluated for their in vivo genotoxicity as measured by sister-chromatid exchange (SCE) and chromosome aberrations (CA). "
03/01/1993 - "Chromosomal aberrations in mouse lymphocytes exposed in vivo and in vitro to aliphatic epoxides."
10/01/1989 - "Sister-chromatid exchange and chromosome aberrations for 4 aliphatic epoxides in mice."
03/01/1984 - "Only the 2 difunctional epoxides, however, were active in an in vitro chromosomal aberration assay with CHO cells. "
05/01/1981 - "Effect of monosubstituted epoxides on chromosome aberrations and SCE in cultured human lymphocytes."

12/01/2010 - "Furthermore, using an animal model of pain associated with inflammation, we show that DHA epoxides, but neither the parent fatty acid nor the corresponding diols, selectively modulate nociceptive pathophysiology. "
01/13/2015 - "Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides."
03/15/2013 - "These fatty acid epoxides, particularly epoxyeicosatrienoic acids (EETs), play an important role in human homeostatic and inflammation processes. "
04/01/2009 - "Epoxide hydrolases are not only a molecular sponge sucking up genotoxic epoxides: new roles in control of blood pressure, inflammation as well as nociception and cell proliferation."
03/01/2006 - "Endogenous hydrolase substrates include arachidonic acid epoxides, which have been involved in regulating blood pressure and inflammation. "

01/01/2002 - "These findings suggest that the breast cancer preventive effect of TAM may be through a competitive epoxidation inhibition mechanism that prevents the formation of E2 and E1 epoxides and consequently, the initiation of breast cancer."
09/11/2014 - "We evaluated synthetic ω-3 epoxides of saturated fatty acids as antiproliferative and pro-apoptotic agents in MDA-MB-231 breast cancer cells. "
10/15/1987 - "Breast fluid cholesterol and cholesterol epoxides: relationship to breast cancer risk factors and other characteristics."
03/01/1987 - "The relative affinity of these epoxides for PgR from T47D human breast cancer cells, however, was only around 5% that of R5020, and affinity beads prepared from them bound very little PgR. "
10/15/1987 - "We measured levels of cholesterol and its oxidation products, 5,6 alpha- and beta-epoxides and their common hydrolysis product cholestane triol, in breast fluids of women without breast disease, compared these levels to serum cholesterol levels, and explored associations of these breast fluid measurements with known breast cancer risk factors and other characteristics. "

07/01/2011 - "Because diol epoxides are converted to tetraols, quantitation of tetraols can potentially be used to identify smokers who may be at higher risk for lung cancer. "
08/11/2000 - "However, the corresponding recombinant Val(105) protein variants tend to show higher catalytic activity than the Ile(105) variants towards bay-region diol epoxides that are thought to be etiological agents in lung cancer. "
04/01/2005 - "In this review, we compare the G --> T spectra induced by PAH o-quinones and diol epoxides with those in lung cancer and show that the main "shaper" of the latter is selection, not mutagenesis. "
05/17/2000 - "Metabolically activated diol epoxides of these compounds, including benzo[a]pyrene diol epoxide (B[a]PDE), have been suggested as causative agents in the development of lung cancer. "
03/01/1992 - "The inhibition of cytosolic EH by tobacco smoke may reduce the inactivation of carcinogenic epoxides in human lung tissues and so may increase a person's susceptibility to lung cancer."