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CQMUH-011

A modified adamantane sulfonamide compound that inhibits macrophage proliferation and possesses anti-inflammatory properties

Networked: 3 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Hu, Xiangnan: 3 articles (12/2021 - 06/2017)
2.	Jiang, Rong: 3 articles (12/2021 - 06/2017)
3.	Liu, Hailin: 3 articles (12/2021 - 06/2017)
4.	Liu, Yingju: 3 articles (12/2021 - 06/2017)
5.	Jiang, Xuejun: 2 articles (12/2021 - 06/2017)
6.	Ling, Qiao: 2 articles (12/2021 - 06/2017)
7.	Wan, Jingyuan: 2 articles (12/2021 - 06/2017)
8.	Qiu, Hongmei: 1 article (12/2021)
9.	Zhu, Hongda: 1 article (12/2021)
10.	Zubreri, Abdallah: 1 article (12/2021)

Related Diseases

1.	Autoimmune Hepatitis 12/01/2021 - "CQMUH-011 mitigates autoimmune hepatitis via inhibiting the function of T lymphocytes." 12/01/2021 - "Here, fresh mouse splenocytes were obtained and stimulated with concanavalin A (ConA, 5 μg/ml) in vitro; and experimental autoimmune hepatitis (AIH) was induced by ConA (20 mg/kg, iv) in vivo, to clarify the protective effects of CQMUH-011 against AIH and its possible mechanisms. "
2.	Infarction (Infarctions) 08/01/2021 - "In vivo, CQMUH-011 administration significantly improved neurological function and infarct volume, and ameliorated the inflammatory cytokines and microglia amount around the injury site of mice. "
3.	Hepatitis 12/01/2021 - "In conclusion, CQMUH-011 exerts potential protective effects against ConA-induced hepatitis, which may be partially attributed to its inhibition of T cells, especially the suppression of the proliferation of CD4+ CD25- CD69+ and CD8+ CD69+ subsets in the spleen. "
4.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 08/01/2021 - "In the present study, we investigated the potential effects and mechanisms of CQMUH-011 on lipopolysaccharide (LPS)-stimulated primary microglia in vitro and transient middle cerebral artery occlusion (t-MCAO)-induced acute cerebral ischemia/reperfusion (I/R) injury in vivo. "
5.	Acute Liver Failure (Fulminant Hepatic Failure) 06/01/2017 - "In this study, we investigated the potential effects and mechanisms of CQMUH-011 on lipopolysaccharide (LPS)-induced RAW264.7 cell activation in vitro and LPS- and D-galactosamine (D-GalN)-induced fulminant hepatic failure (FHF) in vivo. " 06/01/2017 - "CQMUH-011, a novel adamantane sulfonamide compound, inhibits lipopolysaccharide- and D-galactosamine-induced fulminant hepatic failure in mice."

Related Drugs and Biologics

1.	Cytokines
2.	Concanavalin A
3.	Lipopolysaccharides
4.	Galactosamine
5.	Sulfonamides
6.	Adamantane