Concanavalin A

A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.

Networked: 2877 relevant articles (104 outcomes, 248 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ilan, Yaron: 15 articles (01/2021 - 03/2003)
2.	Feng, Dechun: 12 articles (01/2021 - 02/2008)
3.	Gao, Bin: 12 articles (01/2021 - 11/2002)
4.	Annabi, Borhane: 11 articles (11/2021 - 01/2002)
5.	Guo, Chuanyong: 11 articles (07/2018 - 01/2013)
6.	Wang, Fan: 10 articles (07/2018 - 01/2013)
7.	Samson, Michel: 9 articles (12/2018 - 05/2007)
8.	Chen, Kan: 9 articles (07/2018 - 01/2014)
9.	Dai, Weiqi: 9 articles (07/2018 - 01/2013)
10.	Zhou, Yingqun: 9 articles (07/2018 - 01/2013)

Related Diseases

1.	Hepatitis 11/01/2018 - "Man-HSA(D494N)-IFNα2b significantly inhibited liver injury in Concanavalin A (Con-A)-induced hepatitis model mice, and consequently improved their survival rate. " 01/01/2017 - "In a mouse model of Concanavalin A-induced and FasL-mediated hepatitis pharmacological inhibition of LRH-1 resulted in decreased hepatic FasL expression and a significant reduction of liver damage. " 01/01/2023 - "As a kind of mesenchymal-like stromal cells, endometrial regenerative cells (ERCs) have been demonstrated effective in the treatment of Concanavalin A (Con A)-induced hepatitis. " 01/01/2016 - "In this study, we investigated the protective effects of EGCG in concanavalin A (ConA)-induced hepatitis in mice and explored the possible mechanisms involved in these effects. " 01/01/2013 - "This study was designed to examine the protective effects and mechanisms of Nec-1 in concanavalin A- (ConA-) induced hepatitis in mice. "
2.	Autoimmune Hepatitis 01/01/2023 - "This study aimed to investigate the protective effects of KM and its possible mechanisms using a concanavalin A (Con A)-induced autoimmune hepatitis (AIH) model in mice. " 11/01/2020 - "The objective of this study was to investigate the role of AMPK signaling involving the protective effects of RA on concanavalin A (Con A)-induced autoimmune hepatitis (AIH) in mice. " 01/01/2018 - "This study used mesenchymal stem cells (MSCs) as the gene-delivery vehicles for IL-35 gene therapy and investigated their protective effects in Concanavalin A (Con A)-induced autoimmune hepatitis. " 01/01/2016 - "This study was designed to evaluate the protective effects and possible mechanism of MGL against concanavalin A (Con A)-induced autoimmune hepatitis. " 12/01/2023 - "Corrigendum to "Protective effects of Punica granatum (pomegranate) peel extract on concanavalin A-induced autoimmune hepatitis in mice" [Biomed. "
3.	Infections 07/01/1981 - "89Sr-treated mice injected with concanavalin A (Con A) 24 h prior to infection with Listeria monocytogenes (LM) could not enhance the clearance of LM from the spleen. " 12/01/2019 - "In each experiment, spleens were collected at 28-30 days post infection and lymphocytes were isolated and investigated in three ways: their proliferative response to Concanavalin A (ConA) was analysed by MTT proliferation assay; cell death, and expression of CD45 and MHC-I was studied by flow cytometry; and MHC-IA and β-2 microglobulin (B2M) expression was evaluated by real time RT-PCR. " 10/01/2011 - "Furthermore, the expression of EcLECT2 was differentially up-regulated in liver after infection with Staphyloccocus aureus, Vibrio vulnificus, Vibrio parahaemolyticus, Saccharomyces cerevisiae and Singapore grouper iridovirus (SGIV), while the expression was down-regulated after stimulation with Concanavalin A (Con A). " 06/01/2009 - "Moreover, such infection was accompanied by a more profound immune suppression in the former, as evidenced by the extensive loss of T cells, compromised responses to concanavalin A stimulation, and absence of inflammatory infiltrates within the brain. " 08/15/2008 - "To further explore and characterize the PCV2 infection in swine lymphocytes, an in vitro model using concanavalin A (Con A)-stimulated peripheral blood lymphocytes (PBLs) obtained from clinically healthy PCV2-carrier pigs was introduced. "
4.	Neoplasms (Cancer) 06/01/1993 - "Four days before the start of treatment, cancer patient PBMC stimulated with concanavalin A (con A) produced significantly greater amounts of TNF compared to normal controls. " 06/01/2004 - "beta(2)m(-/-) donor cells pre-activated with concanavalin A were more efficiently eliminated compared to resting cells, as were MHC(-) tumor cells. " 12/01/2017 - "Concanavalin A (Con A) holds promise in treating cancerous tumors. " 01/01/1989 - "In one series of trials, spleen cells from strains of chickens with differing levels of susceptibility to MD tumors were stimulated with graded doses of Concanavalin A (Con A) or phytohemagglutin (PHA). " 01/01/1987 - "[Light microscopic studies of concanavalin A binding in the choroid plexus epithelium and ependymal cells of the cerebral ventricle and human tumors derived from those tissues]."
5.	Inflammation (Inflammations) 01/01/2022 - "Further, Ccr9-/- pDCs consistently migrated efficiently to livers with concanavalin A-induced inflammation, and exerted a more effective immunosuppressive effect, resulting in better protection against acute liver inflammation than that demonstrated by WT pDCs. " 12/01/2003 - "In the present study, we investigated the role of the STAT1/T-bet signaling pathway in a murine model of T-cell-mediated liver inflammation induced by the application of concanavalin A (Con A) using newly created STAT1 transgenic mice as well as STAT1- and T-bet-deficient mice. " 01/30/2024 - "G13 suppressed oxidative stress, apoptosis, and inflammation in a Concanavalin A-induced AIH mouse model. " 01/01/2023 - "In vitro concanavalin A (ConA) activation of T cells, including CD8+CD28- cells, was used to mimic inflammation. " 01/01/2021 - "Following Concanavalin-A administration fragmented G184S neutrophils accumulate in liver sinusoids leading to thrombo-inflammation and perivasculitis. "

Related Drugs and Biologics

1.	Pokeweed Mitogens
2.	Antigens
3.	Lipopolysaccharides
4.	Interleukin-6 (Interleukin 6)
5.	Phytohemagglutinins
6.	Mitogens
7.	Interleukin-2 (IL2)
8.	Cytokines
9.	Lectins
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Microspheres (Microsphere)
4.	Intravenous Injections
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow)