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trans-4-hydroxy-L-proline

Also Known As:

N-methyl-trans-4-hydroxy-L-proline; NMH-Pro

Networked: 10 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Cyclic Amino Acids: 3
    - Imino Acids: 11
      - Proline: 3391
        Hydroxyproline: 3935
        trans-4-hydroxy-L-proline: 10

Experts

1.	He, Wenliang: 1 article (04/2022)
2.	Hu, Shengdi: 1 article (04/2022)
3.	Wu, Guoyao: 1 article (04/2022)
4.	Alvarez, Laura: 1 article (01/2022)
5.	Boto, Alicia: 1 article (01/2022)
6.	Columba-Palomares, María C: 1 article (01/2022)
7.	Garduño-Ramírez, María Luisa: 1 article (01/2022)
8.	González-Christen, Judith: 1 article (01/2022)
9.	Maldonado-Magaña, Amalia: 1 article (01/2022)
10.	Marquina, Silvia: 1 article (01/2022)

Related Diseases

1.	Edema (Dropsy) 01/01/2022 - "The further in vivo anti-inflammatory study revealed that the trans-4-hydroxy-l-proline methyl ester derivatives (1f and 2f), together with 1g, were the most effective in inhibiting TPA-induced edema. "
2.	Hyperoxaluria (Oxaluria) 03/01/2004 - "In this study we determined if feeding pigs trans-4-hydroxy-l-proline (HP) increased urine oxalate levels and if it would serve as a model for human hyperoxaluria and stone disease. "
3.	Dehydration (Water Stress) 01/01/2020 - "Recently, a GRE, trans-4-hydroxy-L-proline (Hyp) dehydratase (HypD), was discovered that catalyzes the dehydration of Hyp to (S)-Δ1-pyrroline-5-carboxylic acid (P5C). " 01/01/2017 - "Despite having the same active sites (a pair of Cys/Cys) as hydroxyproline 2-epimerase, which is involved in the metabolism of T4LHyp, the dominant reaction by HypA2 was clearly the dehydration of T3LHyp, a novel type of T3LHyp dehydratase that differed from the known enzyme (Cys/Thr).IMPORTANCE More than 50 years after the discovery of trans-4-hydroxy-l-proline (generally called l-hydroxyproline) degradation in aerobic bacteria, its genetic and molecular information has only recently been elucidated. "
4.	Urolithiasis 07/01/2023 - "A rat model of urolithiasis induced by trans-4-hydroxy-L-proline (HLP) was used. "
5.	Sepsis (Septicemia) 04/01/2017 - "On the other hand, the contents of oxygen generation of proline, citrulline, glutamine, su-beta-hydroxy aspartic acid, citric acid, N-methyl-DL-alanine, serine, lysine, threonine, N-formyl-L-methionine, methionine, alanine, nicotinuric acid, N-methyl-L-glutamic acid, trans-4-hydroxy-L-proline, proline, L-glutamic acid in the plasma of septic rats decreased significantly, which ratios of sepsis/sham group were 0.858, 0.853, 0.834, 0.816, 0.816, 0.814, 0.813, 0.801, 0.793, 0.792, 0.774, 0.766, 0.748, 0.727, 0.716, 0.674, 0.603, respectively (all P < 0.05). "

Related Drugs and Biologics

1.	Esters
2.	Oxalates
3.	Hydro-Lyases (Dehydratases)
4.	Peptide Elongation Factor 2 (EF-2)
5.	Genistein
6.	Citric Acid (Citrate)
7.	Glutamic Acid (Glutamate)
8.	Transcription Factors (Transcription Factor)
9.	Threonine (L-Threonine)
10.	Serine (L-Serine)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)