SP-8356

04/23/2020 - "Therefore, SP-8356 could be a potentially promising therapeutic drug for corneal fibrosis."
04/23/2020 - "In conclusion, SP-8356 is capable enough to prevent corneal haze by preventing pathological fibrosis after severe corneal damage. "
04/23/2020 - "Here, we examined the therapeutic efficacy of novel CD147 inhibiting verbenone derivative SP-8356 ((1S,5R)-4-(3,4-dihydroxy-5-methoxystyryl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one) on corneal fibrosis. "
04/23/2020 - "Topical SP-8356 significantly reduced corneal haze and fibrosis in the alkali-burned cornea. "
04/23/2020 - "A Novel CD147 Inhibitor, SP-8356, Attenuates Pathological Fibrosis in Alkali-Burned Rat Cornea."

05/28/2023 - "For in vivo studies, mice (5-6 weeks old) were implanted with either Saos-2 or MG63 cells on dorsal surface subcutaneously and they were administered with SP-8356 (10 mg/kg) for two weeks prior to bone tumor induction. "
05/28/2023 - "This study aimed to investigate effect of SP-8356 on proliferation and apoptosis of OS cells and tumor growth in mice. "
01/01/2019 - "Functional studies revealed that SP-8356 suppressed serum response element-dependent reporter gene expression and NF-κB-related signaling, resulting in downregulation of many genes related to cancer invasion. "
05/28/2023 - "SP-8356 was found to inhibit proliferation, suppressed cells migration and invasion and decreased OS tumor growth. "
05/28/2023 - "SP-8356 has been reported to exhibit anti-cancer properties in human cancers. "

01/01/2021 - "Since SP-8356 is regarded as a novel Inhibitor of CD147-Cyclophilin, the study aimed to evaluate potential therapeutic effects of SP-8356 for pulmonary embolism-associated cardiac injury. "
01/01/2021 - "Therapeutic effect of SP-8356 on pulmonary embolism-associated cardiac injury is mediated by its ability to suppress apoptosis and inflammation."

05/01/2021 - "Functional studies revealed that SP-8356 inhibits the mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways, which are related to cell proliferation and metastasis, resulting in the downregulation of metastasis-related genes. "

05/01/2021 - "Thus, this study suggests that SP-8356 may be a potential agent for the treatment of liver cancer with multimodal regulation."
05/01/2021 - "Our findings demonstrated that SP-8356 inhibits the proliferation of liver cancer cells by inducing apoptosis and suppressing the mobility and invasion ability of liver cancer cells. "
05/01/2021 - "SP-8356, a (1S)-(-)-Verbenone Derivative, Inhibits the Growth and Motility of Liver Cancer Cells by Regulating NF-κB and ERK Signaling."
05/01/2021 - "Moreover, using an orthotopic liver cancer model, tumor growth was significantly decreased following treatment with SP-8356. "
05/01/2021 - "In this study, SP-8356, a verbenone derivative with anti-inflammatory activity, was investigated for its effect on the growth and migration of liver cancer cells. "