levistilide A

isolated from Angelica sinensis, inhibits hepatic stellate cell proliferation; structure in first source

Also Known As:

(1Z,5S,5aS,8Z,10bS,10cS)-1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-1H-5,10c-ethanonaphtho(1,2-c:7,8-c')difuran-3,10-dione

Networked: 6 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - levistilide A: 6

Experts

1.	Guo, Tao: 2 articles (09/2018 - 01/2017)
2.	Liu, Cheng-Hai: 2 articles (09/2018 - 01/2017)
3.	Zhao, Zhi-Min: 2 articles (09/2018 - 01/2017)
4.	Cheng, Binbin: 1 article (01/2020)
5.	Li, Shu: 1 article (01/2020)
6.	Li, Shuang: 1 article (01/2020)
7.	Liu, Chenghai: 1 article (01/2020)
8.	Zhao, Wei: 1 article (01/2020)
9.	Zhao, Zhimin: 1 article (01/2020)
10.	Liu, Zu-Long: 1 article (09/2018)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 11/01/2023 - "Levistilide A ameliorates neuroinflammation via inhibiting JAK2/STAT3 signaling for neuroprotection and cognitive improvement in scopolamine-induced Alzheimer's disease mouse model."
2.	Neuroinflammatory Diseases 11/01/2023 - "Levistilide A ameliorates neuroinflammation via inhibiting JAK2/STAT3 signaling for neuroprotection and cognitive improvement in scopolamine-induced Alzheimer's disease mouse model." 11/01/2023 - "Here we identify Levistilide A (LA), one of the major active natural terpene lactone constituents from Chinese herbal medicine Angelicae sinensis and Chuanxiong Rhizoma, as a potent neuroinflammation inhibitor for neuroprotection and cognitive improvement of AD. "
3.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2017 - "These findings suggest that levistilide A may be a great potential drug for treating liver fibrosis through antiangiogenesis, and this effect will be verified in other fibrotic animal model studies or by clinical trials." 01/01/2017 - "In this study, we further investigated the mechanisms of levistilide A on liver fibrosis relating to angiogenesis, particularly on the characteristic change in liver sinusoidal endothelial cells. " 01/01/2017 - "This study investigated the effects of levistilide A on liver fibrosis relating to angiogenesis, particularly on the characteristic change in liver sinusoidal endothelial cells. " 01/01/2017 - "The effect of levistilide A on liver fibrosis was confirmed, and its detailed mechanism was also discussed. " 09/01/2018 - "In conclusion, the present study demonstrates for the first time that astragaloside I, levistilide A and calycosin may be the 3 main bioactive components in DBT; their combination exerts anti-liver fibrosis effects in vitro and in vivo."
4.	Fibrosis (Cirrhosis) 01/01/2020 - "Therefore, the present study investigated the effect of levistilide A (Lev A) on hepatic fibrosis via regulation of RAS. " 01/01/2020 - "Levistilide A reverses rat hepatic fibrosis by suppressing angiotensin II‑induced hepatic stellate cells activation."
5.	Arthritis (Polyarthritis) 06/01/2016 - "A fast, sensitive, and reliable ultra-high performance liquid chromatography with tandem mass spectrometry method has been developed and validated for the simultaneous quantitation and pharmacokinetic study of five phthalides (senkyunolide A, ligustilide, butylidenephthalide, 3-butylphthalide, and levistilide A) in rat plasma after oral administration of Huo Luo Xiao Ling Dan (HLXLD) or Angelica sinensis--Ligusticum chuanxiong herb pair (DG-CX) between normal and arthritis rats. "

Related Drugs and Biologics

1.	Scopolamine (Hyoscine)
2.	huo luo xiao ling dan
3.	7,3'-dihydroxy-4'-methoxyisoflavone
4.	3-N-butyl-4,5-dihydrophthalide (NBPA)
5.	ligustilide
6.	3-n-butylphthalide (butylphthalide)
7.	butylidenephthalide
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9.	Terpenes (Terpenoids)
10.	Lactones

Related Therapies and Procedures

1.	Oral Administration