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Lu AE92686

a radioligand for imaging phosphodiesterase 10A; structure in first source

Also Known As:

(11C)Lu AE92686; 5,8-dimethyl-2-(2-((1-11C-methyl)-4-phenyl-1H-imidazol-2-yl)ethyl)-(1,2,4)triazolo(1,5-a)pyridine

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - Lu AE92686: 2
  - Pyridines: 88
    - Lu AE92686: 2

Experts

1.	Antoni, G: 2 articles (06/2020 - 01/2017)
2.	Bodén, R: 2 articles (06/2020 - 01/2017)
3.	Wall, A: 2 articles (06/2020 - 01/2017)
4.	Fällmar, D: 1 article (06/2020)
5.	Persson, Jonas: 1 article (06/2020)
6.	Szalisznyó, K: 1 article (06/2020)
7.	Zora, H: 1 article (06/2020)
8.	Ekselius, L: 1 article (01/2017)
9.	Larsson, E-M: 1 article (01/2017)
10.	Lubberink, M: 1 article (01/2017)

Related Diseases

1.

Schizophrenia (Dementia Praecox)

01/01/2017 - "Patients with schizophrenia had a significantly lower BPND of [11C]Lu AE92686 in striatum (P=0.003) than healthy controls. "
01/01/2017 - "Our study aim was to compare, we believe for the first time, the striatal non-displaceable binding potential (BPND) of the new validated PDE10A ligand [11C]Lu AE92686 between patients with schizophrenia and healthy controls. "
06/01/2020 - "A positron emission tomography (PET) scan with the PDE10A ligand [11C]Lu AE92686 was performed, followed by a 6 min resting-state magnetic resonance imaging (MRI) scan in ten patients with schizophrenia. "
01/01/2017 - "No significant correlation was observed between the BPND for [11C]Lu AE92686 in striatum and age, schizophrenia symptoms, antipsychotic dosage, coffee consumption, smoking, duration of illness or cognitive function in the patients. "

Related Drugs and Biologics

1.	Ligands
2.	Antipsychotic Agents (Antipsychotics)
3.	Coffee