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Ala-Thr-Trp-Leu-Pro-Pro-Arg

targets vascular endothelial growth factor receptor

Also Known As:

A7R heptapeptide; ATWLPPR peptide; alanyl-threonyl-tryptophyl-leucyl-prolyl-prolyl-arginine

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Ala-Thr-Trp-Leu-Pro-Pro-Arg: 3

Experts

1.	Ji, Ailing: 1 article (01/2015)
2.	Ji, Shaoping: 1 article (01/2015)
3.	Li, Mengling: 1 article (01/2015)
4.	Li, Yanzhang: 1 article (01/2015)
5.	Liu, Fang: 1 article (01/2015)
6.	Wang, Jun: 1 article (01/2015)
7.	Wang, Shuaiwei: 1 article (01/2015)
8.	Wu, Dongdong: 1 article (01/2015)
9.	Yang, Ruisheng: 1 article (01/2015)
10.	Chen, Haojun: 1 article (12/2014)

Related Diseases

1.	Diabetic Retinopathy (Retinopathy, Diabetic) 01/01/2015 - "The purpose of this study was to evaluate the effects of an NRP-1 inhibitor, ATWLPPR peptide, on the early stages of diabetic retinopathy. "
2.	Neoplasms (Cancer) 12/01/2014 - "Radiolabeled Arg-Gly-Asp (RGD) and Ala-Thr-Trp-Leu-Pro-Pro-Arg (ATWLPPR) peptide analogs have received interests for their capability to serve as radiopharmaceuticals for imaging integrin αvβ3 and Neuropilin-1 (NRP-1) positive tumors, respectively. " 05/01/2007 - "Because angiogenic endothelial cells of the tumor vasculature represent an interesting target to potentiate the antivascular effect of photodynamic therapy, we recently described the conjugation of a photosensitizer [5-(4-carboxyphenyl)-10,15,20-triphenylchlorin (TPC)], via a spacer [6-aminohexanoic acid (Ahx)], to a vascular endothelial growth factor receptor-specific heptapeptide [H-Ala-Thr-Trp-Leu-Pro-Pro-Arg-OH (ATWLPPR)] and showed that TPC-Ahx-ATWLPPR binds to neuropilin-1. "

Related Drugs and Biologics

1.	Neuropilin-1
2.	Ala-Thr-Trp-Leu-Pro-Pro-Arg
3.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
4.	Radiopharmaceuticals
5.	Photosensitizing Agents (Photosensitizers)
6.	Integrins
7.	Aminocaproic Acid (6 Aminocaproic Acid)
8.	TPC-Ahx-ATWLPPR
9.	arginyl-glycyl-aspartic acid
10.	hydroxide ion

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)