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ME-143

an NADH oxidase inhibitor with antineoplastic activity

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 207
- 1-Ring Heterocyclic Compounds
  - Pyrans: 131
    - Benzopyrans: 198
      - ME-143: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 198
      - ME-143: 4

Experts

1.	Holcombe, Randall F: 1 article (01/2017)
2.	Pintova, Sofya: 1 article (01/2017)
3.	Planutiene, Marina: 1 article (01/2017)
4.	Planutis, Kestutis: 1 article (01/2017)
5.	Carey, Kirstyn T: 1 article (01/2015)
6.	Lim, Sze Chern: 1 article (01/2015)
7.	McKenzie, Matthew: 1 article (01/2015)
8.	Bendell, Johanna C: 1 article (02/2014)
9.	Burris, Howard A: 1 article (02/2014)
10.	Infante, Jeffrey R: 1 article (02/2014)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 01/01/2017 - "ME-143 Is Superior to Genistein in Suppression of WNT Signaling in Colon Cancer Cells."
2.	Neoplasms (Cancer) 02/01/2014 - "This first-in-human dose-escalation study evaluated the dose-limiting toxicities (DLTs), pharmacokinetics, safety, tolerability, and preliminary anti-tumor activity of ME-143 in patients with advanced solid tumors. " 02/01/2014 - "ME-143 was well-tolerated when administered intravenously at the maximally administered/recommended phase 2 dose of 20 mg/kg once weekly to patients with advanced solid tumors. " 01/01/2014 - "Activities of constitutive ENOX1 (CNOX) forms of either cancer or noncancer cells were unaffected by ME-143 over the range of concentrations inhibiting ENOX2. " 02/01/2014 - "A first-in-human dose-escalation study of ME-143, a second generation NADH oxidase inhibitor, in patients with advanced solid tumors." 01/01/2015 - "The second generation synthetic isoflavan analogues ME-143 and ME-344 also exhibit anti-cancer effects, however their specific molecular targets have not been completely defined. "
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2017 - "ME-143 alone and in combination with 5FU and oxaliplatin effectively inhibits the WNT/β-catenin pathway in colorectal cancer cells of diverse genetic background. "

Related Drugs and Biologics

1.	Genistein
2.	NADH oxidase
3.	Isoflavones
4.	Catenins
5.	Electron Transport Complex I (NADH-CoQ Reductase)
6.	Sulfhydryl Compounds (Thiols)
7.	Proteins (Proteins, Gene)
8.	Fluorouracil (Carac)
9.	Disulfides
10.	Oxaliplatin (Eloxatin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)