Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study.
Abstract | BACKGROUND: METHODS: We did an international study at 17 MRI centres in Austria, Germany, and the USA. We used diffusion-weighted MRI from 1002 patients and the Movement Disorders Society Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS III) to develop and validate disease-specific machine learning comparisons using 60 template regions and tracts of interest in Montreal Neurological Institute space between Parkinson's disease and atypical parkinsonism ( multiple system atrophy and progressive supranuclear palsy) and between multiple system atrophy and progressive supranuclear palsy. For each comparison, models were developed on a training and validation cohort and evaluated in an independent test cohort by quantifying the area under the curve (AUC) of receiving operating characteristic curves. The primary outcomes were free water and free-water-corrected fractional anisotropy across 60 different template regions. FINDINGS: INTERPRETATIONS: This study provides an objective, validated, and generalisable imaging approach to distinguish different forms of parkinsonian syndromes using multisite diffusion-weighted MRI cohorts. The diffusion-weighted MRI method does not involve radioactive tracers, is completely automated, and can be collected in less than 12 min across 3T scanners worldwide. The use of this test could positively affect the clinical care of patients with Parkinson's disease and parkinsonism and reduce the number of misdiagnosed cases in clinical trials. FUNDING: National Institutes of Health and Parkinson's Foundation.
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Authors | Derek B Archer, Justin T Bricker, Winston T Chu, Roxana G Burciu, Johanna L McCracken, Song Lai, Stephen A Coombes, Ruogu Fang, Angelos Barmpoutis, Daniel M Corcos, Ajay S Kurani, Trina Mitchell, Mieniecia L Black, Ellen Herschel, Tanya Simuni, Todd B Parrish, Cynthia Comella, Tao Xie, Klaus Seppi, Nicolaas I Bohnen, Martijn Ltm Müller, Roger L Albin, Florian Krismer, Guangwei Du, Mechelle M Lewis, Xuemei Huang, Hong Li, Ofer Pasternak, Nikolaus R McFarland, Michael S Okun, David E Vaillancourt |
Journal | The Lancet. Digital health
(Lancet Digit Health)
Vol. 1
Issue 5
Pg. e222-e231
(09 2019)
ISSN: 2589-7500 [Electronic] England |
PMID | 33323270
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Validation Study)
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Copyright | Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Anisotropy
- Austria
- Biomarkers
- Brain
- Cohort Studies
- Diffusion Magnetic Resonance Imaging
(statistics & numerical data)
- Female
- Germany
- Humans
- Machine Learning
- Male
- Middle Aged
- Multiple System Atrophy
(diagnosis)
- Parkinson Disease
(diagnosis)
- Parkinsonian Disorders
(diagnosis)
- Reproducibility of Results
- Supranuclear Palsy, Progressive
(diagnosis)
- United States
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