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Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)

A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)
Also Known As:
Steele Richardson Olszewski Syndrome; Progressive Supranuclear Ophthalmoplegia; Supranuclear Palsy, Progressive; Palsy, Progressive Supranuclear; Richardson's Syndrome; Steele-Richardson-Olszewski Disease; Supranuclear Palsy, Progressive, 1; Progressive Supranuclear Palsies; Richardson Syndrome; Steele Richardson Olszewski Disease; Supranuclear Ophthalmoplegia, Progressive; Supranuclear Palsies, Progressive; Ophthalmoplegia, Progressive Supranuclear; Progressive Supranuclear Palsy 1; Steele-Richardson-Olszewski Syndrome
Networked: 1232 relevant articles (33 outcomes, 154 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Corticobasal Degeneration
2. Alzheimer Disease (Alzheimer's Disease)
3. Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
4. Multiple System Atrophy
5. Dementia (Dementias)

Experts

1. Dickson, Dennis W: 34 articles (01/2022 - 10/2002)
2. Litvan, Irene: 29 articles (08/2022 - 03/2003)
3. Josephs, Keith A: 25 articles (01/2022 - 10/2002)
4. Höglinger, Günter U: 25 articles (12/2021 - 11/2005)
5. Boxer, Adam L: 19 articles (01/2021 - 08/2012)
6. Whitwell, Jennifer L: 15 articles (01/2022 - 06/2006)
7. Lees, Andrew J: 15 articles (01/2021 - 07/2003)
8. Hasegawa, Masato: 14 articles (01/2022 - 04/2002)
9. Rowe, James B: 14 articles (01/2022 - 12/2016)
10. Zetterberg, Henrik: 14 articles (01/2022 - 02/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Progressive Supranuclear Palsy:
1. Monoclonal AntibodiesIBA
2. gosuranemabIBA
3. Citric Acid (Citrate)FDA LinkGeneric
4. tandospironeIBA
5. davunetideIBA
6. tau Proteins (tau Protein)IBA
7. Levodopa (L Dopa)FDA LinkGeneric
8. Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
9. Zolpidem (Ambien)FDA LinkGeneric
10. coenzyme Q10 (CoQ10)IBA

Therapies and Procedures

1. Therapeutics
2. Transcranial Direct Current Stimulation
3. Physical Therapy Modalities (Physical Therapy Technique)
4. Nutritional Support (Artificial Feeding)
5. Transplantation