Multiple System Atrophy
628
relevant articles (8 outcomes,
62 trials/studies)
found for this Disease
Description:
A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
Also Known As:
Multiple System Atrophy Syndrome; Multisystem Atrophy; Multisystemic Atrophy; Atrophies, Multisystem; Atrophies, Multisystemic; Atrophy, Multiple System; Atrophy, Multisystem; Atrophy, Multisystemic; Multiple System Atrophies; Multisystem Atrophies; Multisystemic Atrophies
Relationship Network
Disease Context: Research Results
Related Diseases
Experts
| 1. | Poewe, Werner:
10 articles
(04/2008 - 08/2003)
|
| 2. | Wenning, Gregor K:
9 articles
(04/2008 - 08/2003)
|
| 3. | Poewe, W:
8 articles
(10/2006 - 01/2000)
|
| 4. | Wenning, G K:
7 articles
(10/2006 - 01/2000)
|
| 5. | Sakakibara, Ryuji:
6 articles
(07/2008 - 02/2003)
|
| 6. | Puschban, Z:
6 articles
(10/2006 - 01/2000)
|
| 7. | Stefanova, Nadia:
5 articles
(04/2008 - 08/2003)
|
| 8. | Ozawa, T:
5 articles
(03/2008 - 08/2001)
|
| 9. | Uchiyama, Tomoyuki:
5 articles
(08/2007 - 02/2003)
|
| 10. | Hattori, Takamichi:
5 articles
(08/2007 - 02/2003)
|
Drugs and Biologics
Drugs and Important Biological Agents (IBA) related to Multiple System Atrophy:
| 1. | Levodopa (L Dopa)FDA LinkGeneric
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| 2. | Dopamine beta-HydroxylaseIBA
07/15/2003
- " Recent findings of an association between human NE deficiency and variants at the dopamine beta-hydroxylase (DBH) gene [Kim et al., 2002] prompted us to investigate these markers in patients with autonomic disorders; 38 with orthostatic intolerance (OI), 26 with pure autonomic failure (PAF), and 39 with multiple system atrophy (MSA)" 07/15/2003
- " Variations in the dopamine beta-hydroxylase gene are not associated with the autonomic disorders, pure autonomic failure, or multiple system atrophy." 01/01/1998
- " Four different forms of primary autonomic failure (multiple system atrophy, pure autonomic failure, Parkinson's disease and dopamine beta-hydroxylase deficiency) have been described" 08/01/1991
- " The effect of a balanced liquid meal on supine and postural blood pressure (BP) responses was investigated in three groups of patients with chronic autonomic failure; 10 with associated neurological impairment (multiple system atrophy (MSA), Shy-Drager syndrome) and seven without (of which five had pure autonomic failure (PAF); and two had a deficiency of the enzyme dopamine beta hydroxylase, DBH-deficiency)" 01/01/2006
- " DOPS improved orthostatic hypotension in patients with familial amyloid polyneuropathy, congenital deficiency of dopamine beta hydroxylase, pure autonomic failure and multiple system atrophy"
Order ALL the reference details at left...
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| 3. | Trimethaphan (Trimetaphan)IBA
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