Gastroprotective effect of Lycium barbarum polysaccharides and C-phycocyanin in rats with ethanol-induced gastric ulcer.

Abstract

This study investigated the gastroprotective effect of Lycium barbarum polysaccharides (LBP) and C-phycocyanin (C-PC) in rats with ethanol-induced gastric ulcer. Rats were divided into 5 groups: normal, ulcer, ulcer treated with 100 mg/kg bw LBP, ulcer treated with 50 mg/kg bw C-PC, and ulcer treated with 50 mg/kg bw LBP and 25 mg/kg bw C-PC. Pretreatment with LBP and/or C-PC was given a week before ulcer induction. Ulcer induction was produced by 50% ethanol administration orally every other day for 4 weeks. After 5-week treatment, the histopathological observation showed that LBP or C-PC attenuated the severity of gastric mucosal damage. LBP decreased serum malondialdehyde (MDA) levels and gastric interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) levels, and myeloperoxidase (MPO) activity. C-PC decreased serum MDA levels and gastric tumor necrosis factor-α (TNF-α), IL-1β, IL-6, ICAM-1 levels, and MPO activity. Combined LBP and C-PC decreased serum MDA levels and gastric TNF-α, IL-1β, IL-6, and ICAM-1 levels. LBP and/or C-PC increased gastric heat shock protein 70 and non-protein sulfhydryl compounds. Rats with ulcer and treatment had enriched with the family Bacillaceae. Therefore, pretreatment with LBP and/or C-PC attenuated ethanol-induced gastric ulcer in rats via suppressing oxidation and inflammation and increasing gastroprotection.

• Authors: Yu Zhi Lian, I-Hsuan Lin, Yu-Chen Yang, Jane C-J Chao
• Journal: International journal of biological macromolecules (Int J Biol Macromol) Vol. 165 Issue Pt A Pg. 1519-1528 (Dec 15 2020) ISSN: 1879-0003 [Electronic] Netherlands
• PMID: 33058973 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Chemical References

• Anti-Ulcer Agents
• Plant Extracts
• Polysaccharides
• Protective Agents
• Phycocyanin
• Ethanol

Topics

• Animals
• Anti-Ulcer Agents (chemistry, pharmacology)
• Ethanol (toxicity)
• Gastric Mucosa (drug effects, pathology)
• Humans
• Lycium (chemistry)
• Oxidative Stress (drug effects)
• Phycocyanin (chemistry, pharmacology)
• Plant Extracts
• Polysaccharides (chemistry, pharmacology)
• Protective Agents (chemistry, pharmacology)
• Rats
• Stomach (drug effects, pathology)
• Stomach Ulcer (chemically induced)