Stomach Ulcer (Gastric Ulcer)

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4562 relevant articles (318 outcomes, 659 trials/studies) found for this Disease

Description: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

Also Known As:

Gastric Ulcer; Gastric Ulcers; Stomach Ulcers; Ulcer, Gastric; Ulcer, Stomach; Ulcers, Gastric; Ulcers, Stomach

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 31

Gastrointestinal Diseases: 1230

Peptic Ulcer: 6982

Stomach Ulcer: 4562

Stomach Diseases: 370

Peptic Ulcer: 6982

Stomach Ulcer: 4562

Related Diseases

1.	Duodenal Ulcer (Curling's Ulcer)
2.	Ulcer
3.	Stomach Ulcer (Gastric Ulcer)
4.	Hemorrhage
5.	Peptic Ulcer (Peptic Ulcers)

Experts

1.	Konturek, P C: 8 articles (08/2008 - 01/2001)
2.	Konturek, S J: 8 articles (08/2008 - 01/2001)
3.	Brzozowski, T: 8 articles (08/2008 - 01/2001)
4.	Arakawa, T: 7 articles (12/2006 - 01/2000)
5.	Fujiwara, Y: 6 articles (12/2006 - 01/2000)
6.	Watanabe, T: 6 articles (12/2006 - 01/2000)
7.	Higuchi, K: 6 articles (12/2006 - 01/2000)
8.	Cho, C H: 6 articles (01/2003 - 01/2000)
9.	Wallace, John L: 5 articles (08/2008 - 10/2002)
10.	Arakawa, Tetsuo: 5 articles (08/2007 - 07/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Stomach Ulcer:

1.	Ranitidine (Zantac)FDA LinkGeneric 06/10/1990 - "The results of this trial suggest that, in the treatment of gastric ulcers, the early-evening administration of ranitidine 300 mg is more effective than other modes of ingestion." 07/01/1993 - "Ranitidine 150 mg twice daily is effective for the treatment of gastric ulcers. " 07/01/1993 - "Ranitidine 300 mg at bedtime is effective for gastric ulcers: a 12-wk, multicenter, randomized, double-blind, placebo-controlled comparison. " 12/01/1989 - "The results suggest that ranitidine is effective in preventing gastric ulcer relapse." 07/01/1986 - "The results of this trial show that 300 mg of ranitidine administered at night is an effective and safe alternative to the current twice daily regimen for the short term treatment of gastric ulcer." Order ALL the reference details at left...
2.	Cimetidine (Biomet)FDA LinkGeneric 01/01/1980 - "We studied the healing efficacy of cimetidine or placebo on 24 endoscopically proven prepyloric gastric ulcer outpatients in randomized controlled prospective double blind trial. " 01/01/1984 - "It is concluded with caution that cimetidine might be effective in haemorrhage from gastric ulcer in patients 60 years and older. " 01/01/1988 - "The efficacy of a 4-week cimetidine treatment was examined by a double-blind randomized study in 37 outpatients with endoscopically verified chronic gastric ulcer. " 10/01/1983 - "The efficacy of Cimetidine in gastric ulcer, however requires further study." 01/01/1994 - "Equal efficacy of both cimetidine formulations for the healing of gastric ulcer." Order ALL the reference details at left...
3.	Omeprazole (Esomeprazole)FDA LinkGeneric 04/01/1999 - "This study demonstrates that omeprazole paste, 4 mg/kg bwt per os, once daily, is highly effective in healing gastric ulcers in Thoroughbred racehorses and that either a full dose or half dose of omeprazole paste effectively prevents the recurrence of EGUS. " 07/01/2003 - "It was concluded that omeprazole paste at 4 mg/kg BW orally, once daily is highly effective in healing gastric ulcers in standardbred racehorses in training and that a dose of 2 mg/kg BW orally, once daily, effectively prevents the recurrence of gastric ulcers in most horses." 01/01/1992 - "The results indicate that omeprazole is highly effective for the treatment of refractory gastric ulcers." 04/01/1999 - "A multicentre, blinded, randomised complete-block, field trial was conducted with 140 horses and foals age 4 weeks-28 years to determine if omeprazole paste is effective and safe in promoting healing of spontaneous gastric ulcers under a variety of field conditions and in different breeds and ages of horses. " 04/01/1999 - "By Day 28, gastric ulcers were completely healed in 77% of omeprazole-treated horses, while 92% were significantly (P < 0.01) improved. " Order ALL the reference details at left...
4.	Misoprostol (Cytotec)FDA LinkGeneric 01/01/1995 - "The efficacy of 400 micrograms misoprostol daily in the prevention of NSAID (non-steroidal anti-inflammatory drug)-induced gastric ulcer has been proven. " 11/11/1996 - "CONCLUSIONS: The use of misoprostol, but no that of H2 blockers, was beneficial in the prevention of NSAID-induced gastric ulcers. " 03/01/1990 - "Misoprostol has a disadvantageous safety profile relative to available agents but is effective in preventing NSAID-induced gastric ulcers. " 09/01/1989 - "Misoprostol has been shown to be an effective agent for the prevention of NSAID-induced gastric ulcers. " 12/01/1985 - "These results (part of a multicenter, international study) suggest that the divided daily dose of 800 micrograms misoprostol is safe and effective in the short-term treatment of gastric ulcer." Order ALL the reference details at left...
5.	Sucralfate (Carafate)FDA LinkGeneric 03/01/1984 - "Controlled therapeutic trials have demonstrated that sucralfate 1g 4 times daily is effective in increasing the rate of healing of duodenal and gastric ulcer over a period of 4 to 8 weeks. " 08/08/1991 - "The results suggest that 2 g sucralfate twice daily is as effective in the healing of gastric ulcer as 1 g sucralfate q.i.d." 08/08/1991 - "Clinical efficacy of sucralfate in the treatment of gastric ulcer." 07/01/1990 - "Maintenance treatment with sucralfate delayed symptoms of gastric ulcer recurrence. " 01/01/2007 - "The purpose of the investigation was to study the effects of sucralfate on the biochemical composition as well as the anti-radicals and antioxidative activity (ARA; AOA) of the gastric supra-epithelial mucosal layer (GSEML) in patients with Helicobacter pylori (HP)-associated gastric ulcer (GU). " Order ALL the reference details at left...
6.	Ethanol (Ethyl Alcohol)IBA 03/01/2007 - "glandulosa (AG) showed a dose-dependent effect and significant reduction of gastric ulcers induced by absolute ethanol at the doses of 500 (57%) and 1000 mg/kg (85%) in relation to the control group. " 10/03/2005 - "Pharmacological experiments clearly demonstrated that the extracts of all plants given orally showed significant gastric protection against the ethanol-induced gastric ulcer model in rats. " 04/26/2005 - "The present work aimed at testing, in a rat model of ethanol-induced gastric ulceration, a local folk medicinal claim that dates are beneficial in gastric ulcers in humans. " 01/01/2007 - "In summary, our results demonstrate that OSO pretreatment exerts protective effects in ethanol-induced gastric ulcers in rats. " 06/28/2005 - "Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats." Order ALL the reference details at left...
7.	Famotidine (Pepcid)FDA LinkGeneric 01/01/1987 - "The findings show that the new H2-receptor antagonist famotidine, administered as a single evening dose, significantly speeds the healing of benign gastric ulcers and that it is a safe and highly effective treatment of gastric ulceration. " 10/24/1986 - "Analysis of data from 15 countries has shown that famotidine is more effective than placebo in treating gastric ulcers. " 04/01/1991 - "A multicentre, double-blind, randomized, placebo-controlled trial was undertaken to investigate the therapeutic efficacy of a nocturnal dose of famotidine 20 mg to reduce the 1 year relapse rate of recently healed gastric ulcers. " 10/01/1989 - "As shown in placebo-controlled trials, famotidine is effective in healing both duodenal and gastric ulcers. " 01/01/1992 - "Famotidine therefore proved effective in the treatment of gastric ulcer and was well tolerated on a short term basis." Order ALL the reference details at left...
8.	Indomethacin (Indometacin)FDA LinkGeneric 11/01/2005 - "racemosus was more effective in reducing gastric ulcer in indomethacin-treated gastric ulcerative rats, whereas W. " 08/01/2007 - "Trx-1 inhibits indomethacin-induced apoptotic signaling and gastric ulcer formation, suggesting that it may have a preventive and therapeutic potential against indomethacin-induced gastric injury." 04/01/2009 - "Ten rats were used to study the induction of gastric ulcer by indomethacin (25 mg/kg/stat). " 11/07/2009 - "CONCLUSION: EP4-selective agonist may prevent indomethacin-induced gastric lesions and promote healing of existing and indomethacin-aggravated gastric ulcers, via promoting proliferation and survival of mucous epithelial cells." 11/07/2009 - "In the absence of indomethacin, the EP4 agonist even accelerated chronic gastric ulcer healing and suppressed inflammatory cell infiltration in the granulation tissue. " Order ALL the reference details at left...
9.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 02/13/1995 - "This study suggests that the aspirin-induced gastric ulcer may not originate in the PVH but in the NTSm-DMX system." 03/01/1986 - "This dose-response effect, evident in both endoscopic and microbleeding studies done after acute or short-term aspirin administration, is also associated with the risk of developing chronic gastric ulcer. " 10/01/1975 - "A study of the aspirin intake of 61 patients with gastric ulcer revealed that 32 (52%) took 15 or more aspirins each week, compared to 6 (10%) age- and sex-matched controls who took such amounts (P less than 0.001). " 11/01/2008 - "METHODS: Eleven patients who developed gastric ulcers while undergoing low-dose enteric-coated aspirin therapy were enrolled. " 01/01/2007 - "CONCLUSIONS: Aspirin enhance the recurrence of gastric ulcer. " Order ALL the reference details at left...
10.	lansoprazole (Prevacid)FDA LinkGeneric 01/01/1995 - "The results of this study demonstrate that 30 mg lansoprazole once daily is remarkably effective in healing gastric ulcers because of its potent acid suppression. " 04/01/1998 - "Our purpose was to compare the safety and efficacy of lansoprazole 15 mg and 30 mg with placebo in preventing recurrence in 49 patients with a history of gastric ulcer. " 08/01/1995 - "OBJECTIVES: A multicenter, double-blind study was conducted in 268 patients to compare the safety and efficacy of 15, 30, and 60 mg of lansoprazole and placebo in the treatment of gastric ulcer. " 06/01/1996 - "A trial of lansoprazole in refractory gastric ulcer." 01/01/2004 - "At week 12, the percentages of patients who were free from gastric ulcer were 80% with lansoprazole 15 mg and 51% with placebo. " Order ALL the reference details at left...

Therapies and Procedures

1.	Ligation 10/03/2005 - "In the gastric ulcer induced by pylorus ligature model, the administration of HAE by oral and intraduodenal routes inhibited the gastric lesion index by 79 and 52% (500 mg/kg), respectively. " 10/01/2004 - "Extract A3 also inhibited the formation of gastric ulcers induced by pylorus ligation, when administered both orally and intraperitoneally. " 03/01/2003 - "METHOD: The anti-gastric ulcer effects of Xuedan was investigated with gastric ulcer models induced by being immersed in cold water, having pylorus ligature and HAC injected into serous membrane in rats. " 01/01/1996 - "Four of the letter five patients had perforation of the gastric ulcer; three of them were treated surgically (in two cases by partial resection of the stomach, in one by ligation of the vessels in ulceration area) and in one case the conservative treatment was applied. " 09/01/1995 - "Nevertheless, it inhibited gastric ulcer induced by pylorus-ligation at doses (50 mg kg-1) that were ineffective in decreasing the volume. " Order ALL the reference details at left...
2.	Gastrectomy 10/01/1975 - "Of 61 patients with gastric ulcer subjected to an improved technique of segmental gastrectomy, 26 were available for follow-up study for 1 to 10 years; evaluations were made mainly on the postoperative reduction of gastric acid secretion and motor function of the gastric remnant. " 06/01/1967 - "Pylorus-preserving gastrectomy as an improved operation for gastric ulcer." 07/01/2005 - "MATERIAL AND METHODS: Our study was achieved on a group of 212 patients, clinically diagnosed with gastric ulcer and having partial gastrectomy. " 11/01/1947 - "Subtotal gastrectomy for gastric ulcer; study of end results." 08/01/2007 - "A 67-year-old woman underwent distal gastrectomy (Billroth type II reconstruction) for gastric ulcer perforation in March, 2001. " Order ALL the reference details at left...
3.	Endoscopic Hemostasis 07/01/2001 - "Endoscopic hemostasis for hemorrhagic gastric ulcer is effective and safe, even for such elderly patients." 02/01/2009 - "Gastrointestinal: Aneurysmal artery in a gastric ulcer after endoscopic hemostasis." 03/01/2004 - "We concluded that endoscopic hemostasis using high-frequency hemostatic forceps for hemorrhagic gastric ulcer is safe and effective method." 03/01/2004 - "[Endoscopic hemostasis using high-frequency hemostatic forceps for hemorrhagic gastric ulcer]" 03/01/2009 - "Endoscopic hemostasis of bleeding gastric ulcer with a combination of multiple hemoclips and endoloops." Order ALL the reference details at left...
4.	Vagotomy 08/01/1980 - "AGC was significantly greater (P < 0.01) than the control values in 3 patients with a vagotomy and pyloroplasty and a gastric ulcer, 29.8 +/- 5.0. " 04/01/1984 - "Two hundred thirteen patients were evaluated to establish the efficacy of vagotomy and pyloroplasty in the treatment of benign gastric ulcer disease. " 09/01/1963 - "TREATMENT OF GASTRIC ULCER (IN SITU) BY VAGOTOMY AND PYLOROPLASTY: A CLINICAL STUDY." 08/01/1996 - "We conclude that vagotomy, pyloroplasty, and wedge excision or biopsy of a benign gastric ulcer is a comparable operation to a more major gastric resection, with or without vagotomy, in the surgical management of gastric ulcer. " 09/01/1994 - "We examined whether or not unilateral vagotomy delays healing of gastric ulcers induced on the denervated mucosa. " Order ALL the reference details at left...
5.	Oral Administration 05/01/2009 - "PURPOSE: Gastrointestinal deposition of nanoparticles was examined after oral administration to mice suffering from an experimental gastric ulcer model. " 11/01/2005 - "HYPOTHESIS: Repeated oral administration of hypertonic electrolyte solution is associated with exacerbation of gastric ulcers in mature horses. " 05/01/1999 - "Oral administration of DHC (100 mg/kg per day) for 14 consecutive days had no effect on gastric ulcer healing in rats. " 09/01/1996 - "senticosus-extract (50, 100 and 500 mg/kg, per day) dissolved in 1 ml distilled water did not show any protective effect on gastric ulcer, but the protective effect was observed in a dose-dependent manner from the oral administration of the extract (50, 100 and 500 mg/kg, per day) for 2 weeks. " 04/01/1994 - "Oral administration of this extract (50, 100, or 150 mg/kg) significantly prevented the occurrence of water immersion stress-induced gastric ulcers in a dose-responsive manner. " Order ALL the reference details at left...

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