Ulcer

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15185 relevant articles (1121 outcomes, 1610 trials/studies) found for this Disease

Description: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.

Also Known As:

Ulcers

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2211

Ulcer: 15185

Related Diseases

1.	Hemorrhage
2.	Pain (Aches)
3.	Ulcer
4.	Duodenal Ulcer (Curling's Ulcer)
5.	Stomach Ulcer (Gastric Ulcer)

Experts

1.	Hung, Chen-Road: 7 articles (12/2007 - 09/2002)
2.	Chan, Francis K L: 7 articles (04/2007 - 12/2002)
3.	Brzozowski, T: 7 articles (09/2005 - 10/2000)
4.	Konturek, S J: 7 articles (09/2005 - 10/2000)
5.	Konturek, P C: 6 articles (09/2005 - 10/2000)
6.	Samonina, G E: 6 articles (09/2004 - 02/2000)
7.	Okabe, Susumu: 5 articles (01/2008 - 04/2002)
8.	Brzozowski, Tomasz: 5 articles (03/2005 - 04/2002)
9.	Slomiany, A: 5 articles (01/2003 - 05/2000)
10.	Slomiany, B L: 5 articles (01/2003 - 05/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ulcer:

1.	Omeprazole (Esomeprazole)FDA LinkGeneric 01/01/1989 - "In conclusion, omeprazole 20 mg each morning was found to be safe and highly effective for treatment of gastric and prepyloric ulcer in Korean patients, producing a 98% healing rate" 01/01/1989 - "The healing efficacy of omeprazole was assessed in 57 Korean patients with endoscopically-proven gastric (GU) and/or prepyloric (PPU) ulcers of at least 5 mm diameter" 04/01/1987 - "In conclusion, omeprazole is very effective in preventing gastric stress ulcers in the spinal cord transected rat" 04/01/1999 - "Horses treated with omeprazole had significantly (P < 0.01) more improvement in ulcer scores at the end of the study compared with controls" 06/01/2005 - "DG showed significant protection against CRU (68.37%), AL (88.87%), ASP (38.2%), PL (40.63%) and HST (63.15%) induced ulcer models, whereas standard drug omeprazole (OMZ) showed protection index of 83.86, 56.35, 70.31 and 84.21%, respectively in CRU, ASP, PL and HST models" Order ALL the reference details at left...
2.	Ranitidine (Zantac)FDA LinkGeneric 04/27/1989 - "Patients who drank alcohol, smoked, had a history of ulcer disease, or had duodenal scarring or erosion at the time of entry into the study were at the greatest risk for recurrence and benefited the most from prophylactic ranitidine" 02/13/1982 - "Ranitidine appears to be a safe and highly effective treatment of gastric ulceration, with about 90% of ulcers healed after eight weeks." 08/01/1985 - "Nocturnal gastric acid inhibition was significantly greater in patients who responded to ranitidine than in those whose ulcer did not heal" 06/01/1982 - "Ulcer symptoms resolved or improved in a greater proportion of patients on ranitidine, and this was associated with a significantly lower antacid consumption" 02/01/1990 - "Other ulcer related symptoms such as fullness etc. were more rapidly relieved with ranitidine" Order ALL the reference details at left...
3.	Cimetidine (Biomet)FDA LinkGeneric 01/01/1978 - "In most studies Cimetidine is superior to placebo or equipotent to a high dose antacid regimen, the latter being accepted to be of beneficial effect on ulcer healing" 07/01/1991 - "Cimetidine provided the best protection against stress-induced ulcers" 01/01/1978 - "3. The marked sustained reduction of acid production most probably accounts for the protective effects of cimetidine against ulcer production in the rat stomach." 09/01/1978 - "Cimetidine, therefore, seems to be very effective in preventing stress induced ulcers in rat when instilled in the stomach before the stress." 01/01/1988 - "The decrease in the size of the ulcer was significantly greater in the first two weeks of cimetidine treatment than in the cimetidine-placebo group (P less than 0.05)" Order ALL the reference details at left...
4.	Sucralfate (Carafate)FDA LinkGeneric 12/01/2005 - "After the intervetion, there was a significant improvement in hand-hygiene practices (p<0.001) among healthcare providers and increased use of sucralfate (p=0.05) for stress ulcer prophylaxis" 02/01/2001 - "The drug given orally in doses of 200 and 600 mg/kg twice daily for five days, showed significant protection against all the above experimental ulcer models and the results were comparable with those elicited by sucralfate (SF, 250 mg/kg, p.o., BD x 5 days)" 01/01/1980 - "Treatment (sucralfate), ulcer history, size of previous ulcer(s), prestudy healing time, and prestudy healing stage attained (red or white scarring) were associated with a significant reduction in recurrence rate" 07/01/1994 - "The potential advantages of sucralfate lie in the better quality of ulcer healing associated with longer duration of remission." 06/09/1989 - "It is concluded that 1 g sucralfate twice daily is more effective than a placebo and is safe for the maintenance treatment of duodenal and pyloric ulcer disease." Order ALL the reference details at left...
5.	Indomethacin (Indometacin)FDA LinkGeneric 11/01/1986 - "These compounds, as well as the 7-(2-chloropropionyl) derivative 2d, also exhibited antiinflammatory activity; in addition, 2c,d were highly effective in inhibiting indomethacin-induced ulcers in the rat." 02/01/1993 - "After a 2-week treatment with indomethacin, a histological study of the ulcers showed that the length of rupturing of the muscularis mucosa was significantly greater than that observed in the control group" 11/01/2004 - "It also afforded significant protection against alcohol and indomethacin induced ulcer as well as stress induced ulceration" 01/01/1989 - "Indometacin was effective in producing ulcers in the gastric antrum and small intestine, but not in the corpus of the stomach, when it was given to rats fasted for 24 h and fed for 1 h before drug administration" 03/01/2002 - "3. The gastric mucosal protective effects of LP (1-20 mg/kg), OP (0.5-10 mg/kg) and PD (1-20 mg/kg), administered either orally or subcutaneously (s.c.) 30 min before the administration of AE or indomethacin, were dose dependent against both models of ulcer induction" Order ALL the reference details at left...
6.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/01/1992 - "It is effective in preventing NSAID-induced ulcers, and does not interfere with the desired analgesic or anti-inflammatory effects of NSAIDs" 01/01/1989 - "H2-receptor antagonists have proved effective in ulcer treatment, and their use as prophylaxis against the side effects of NSAIDs is being widely studied" 01/01/1988 - "H2-receptor antagonists have proved effective in ulcer treatment, and their use as prophylaxis against the side-effects of NSAIDs is being widely studied" 09/01/2008 - "METHODS: To clarify this situation we have performed a systematic literature search to find randomized controlled trials comparing the efficacy of eradication in patients receiving NSAIDs to prevent ulcer development" 09/15/2001 - "The author created a study (1989-1994) to determine the efficacy of one exposure (ulcer-healing drugs) in preventing the serious upper gastrointestinal toxicity associated with another exposure (nonsteroidal anti-inflammatory drugs (NSAIDs))" Order ALL the reference details at left...
7.	Ethanol (Ethyl Alcohol)IBA 08/01/1996 - "It is highly effective against ethanol-induced ulcers" 03/21/2007 - "Ethanol extract of Toona ciliata showed significant reduction in gastric volume, free acidity, total acidity and ulcer index" 01/01/2002 - "Further it showed significant cytoprotective activity against ethanol insult, that was evident from significant reduction in ulcer index" 06/01/2005 - "CONCLUSIONS: The present study clearly demonstrates that bone marrow-derived cells are involved in the regeneration of the stomach after ethanol-induced ulcers in rats." 01/01/1990 - "In a further study with ethanol-induced ulcer model of the rat, the physiological significance of FNRS was examined" Order ALL the reference details at left...
8.	Misoprostol (Cytotec)FDA LinkGeneric 09/06/2004 - "Maintenance of ulcer healing is significantly greater in those who receive ongoing PPI treatment compared with placebo, and adverse events and treatment withdrawals are fewer compared with their occurrence in persons treated with misoprostol" 01/01/1992 - "Although therapy for patients with NSAID-induced ulcers or those at high risk of developing them is still a matter of debate, the current literature supports the use of misoprostol as the only drug effective for the prevention of both NSAID-induced gastric and duodenal ulceration" 01/08/2001 - "That the Misoprostol Ulcer Complications Outcomes Safety Assessment (MUCOSA) trial found full-dose misoprostol to be more effective in ulcer prevention than it was in prevention of ulcer complications suggests that either many of the ulcer complications were related to H" 03/01/2000 - "PPI have now been definitively shown to be more effective in the relief of symptoms and in the healing and prevention of ulcers/erosions than H2-antagonists and also better tolerated than misoprostol" 05/01/1990 - "Studies to date indicate that the only appropriate therapy to prevent NSAID ulcers is misoprostol, and that this drug is also effective in healing such ulcers while NSAID treatment is continued" Order ALL the reference details at left...
9.	AntacidsIBA 06/21/1979 - "So far antacids have not been shown to be more effective in relieving ulcer symptoms than placebo" 01/01/1996 - "Antacids for postoperative prevention of stress ulcer in infants: a dose finding study]" 09/01/1993 - "The advent of controlled endoscopic trials and the emergence of the H2-receptor blockers as a yardstick of ulcer therapy, however, facilitated reappraisal of the value of antacids in various conditions" 09/01/1991 - "Even with the antisecretory compounds, the relationship between gastric acid and ulcer healing gives rise to perplexity: antacids prove effective at widely varying doses; pirenzipine and H2-blockers, which are clinically equieffective, differ considerably in antisecretory efficacy; H2-antagonist studies on early vs late postprandial dosing yield contradictory clinical results; morning and bedtime single administrations of H2-antagonists prove equiactive on ulcer healing, leading to a reappraisal of the alleged importance of nocturnal acidity" 06/01/1990 - "Even with the antisecretory compounds, the relationship between gastric acid and ulcer healing gives rise to perplexity: antacids prove effective at widely varying doses; pirenzipine and H2-blockers, which are clinically equieffective, differ considerably in antisecretory efficacy; H2-antagonist studies on early vs late postprandial dosing, yield contradictory clinical results; morning and bedtime single administration of H2-antagonists prove equiactive on ulcer healing, leading to a appraisal of the alleged importance of nocturnal acidity" Order ALL the reference details at left...
10.	lansoprazole (Prevacid)FDA LinkGeneric 01/01/1991 - "AG-1749 raised the percentage of time with high pH to 99% from the 68% obtained with an H2RA and cured 88% of this type of ulcer" 10/15/2003 - "Lansoprazole reduces ulcer relapse after eradication of Helicobacter pylori in nonsteroidal anti-inflammatory drug users--a randomized trial." 07/01/1999 - "RESULTS: Within 1 month of study initiation, 27% (four out of 15) of placebo-treated patients experienced ulcer recurrence as compared to 13% (two out of 15) and 6% (one out of 18) of lansoprazole 15 mg and 30 mg treated patients, respectively" 01/01/1995 - "In study II, the ulcer contraction rate after 8 weeks of treatment with lansoprazole was 71.8%, significantly higher than that achieved with H2-receptor antagonists" 01/01/1995 - "The effect of lansoprazole versus an H2-receptor antagonist on the contraction of ulcer echoes (study II) was also investigated" Order ALL the reference details at left...

Therapies and Procedures

1.	Vagotomy 01/01/1988 - "Thus basal and stimulated acid output is normal in most ulcer patients, and this is also so for gastric and duodenal pH. Gastric acid secretion does not separate patients with rapid recurrence after medical treatment from those with a long period of remission, and acid secretion is usually not higher in patients with recurrence after vagotomy than in patients without relapse" 12/01/1990 - "It was established that intraoperative pH measurement, carried out by an improved procedure, provided for objective control over complete and adequate vagotomy, made it possible to predict the risk of ulcer recurrence in the postoperative period and, in accordance with that, to choose the methods for its prevention." 01/01/2008 - "Vagotomy at the patients with ulcers after primary resections demonstrates good results" 01/01/2000 - "This method of vagotomy was used in 46 patients with ulcer disease of the duodenum and gave good results" 01/01/1993 - "With the availability of effective medication for control of gastric acidity, the need for selective vagotomy or elective operative procedure for ulcers is fast disappearing." Order ALL the reference details at left...
2.	Amputation 01/01/2005 - "Pooled data from five trials on diabetic ulcers (118 patients) suggested a significant reduction in the risk of major amputation with HBOT (RR: 0.31; c.i. 0.13 to 0.71) with a NNT of 4 (c.i. 3 to 11)" 05/01/2002 - "With sensitivity analysis, CS and Ed remained cost-effective (lifetime cost per quality-adjusted life year saved, <$60,000) if amputations and the cost of ulcer treatment were eliminated or if the cost of prophylaxis was increased to 600% of the base-case" 07/01/2006 - "As conventional medical treatments had not improved these ulcers and surgical treatment was considered unfeasible, amputation of the right lower limb below the knee appeared to represent the only option" 03/01/2006 - "We examined the efficacy of total-contact casts (TCC) in diabetic amputees with nonhealing partial foot amputation site neuropathic ulcers" 06/01/2008 - "The aim of this study was to determine whether intensive treatment and education strategies for diabetic patients with ulcers help in preventing leg amputation" Order ALL the reference details at left...
3.	Transplants (Transplant) 04/01/2000 - "Postoperative angiography showed satisfactory graft patency and distal run-off, and the ulcer improved" 06/01/2002 - "Pinch grafts are very useful for arterial ulcers" 03/01/2007 - "PURPOSE: To evaluate the efficacy of using a porcine small intestinal submucosa (SIS) graft for the surgical repair of deep melting ulcers in dogs and cats" 01/01/2004 - "However, incisional release of tight skin above the knee joint and resurfacing the defect with split-thickness skin graft (mean size, 118.26 +/- 35.32 cm2) eliminated excessive tension and allowed the ulcers to heal spontaneously and permanently" 01/07/1991 - "Nine of 11 patients who received a vein valve transplant had falls in their ambulant venous pressures, improvement in the nutrition of their skin and healing of their recurrent ulcers." Order ALL the reference details at left...
4.	Lasers (Laser) 11/01/2005 - "Laser energy density of 5 J/cm2 was the most effective for maximally complete healing of radiation ulcers." 01/01/2001 - "The efficacy of local use of a new drug miliacil in combination with laser radiation was studied in 44 patients with trophic ulcer of different origin" 01/01/1995 - "4 cases of larynx contact ulcer cured with the use of laser resection of vocal process of arytenoid cartilage were presented" 01/01/1986 - "It is shown that the efficacy of laser radiation treatment is dependent on the ulcer localization." 01/01/1981 - "Results were improved by meticulous endoscopic washing of the ulcer crater and care in setting the laser" Order ALL the reference details at left...
5.	Debridement 12/01/2003 - "The latter two procedures may be beneficial in the treatment of nonhealing ulceration in horses, but the results of this study suggest that these procedures should only be performed following failure of the ulcer to heal after epithelial debridement." 06/01/2007 - "Reduced debridements and improved phagocytosis were statistically significant, indicating beneficial effects of immunomodulation for ulcer healing." 05/01/2006 - "On minimal improvement in the epithelial defect in 1 week, surgical debridement of the ulcer base was performed" 06/01/2008 - "In this study we compared Versajet with conventional surgical techniques in the debridement of lower extremity ulcers to assess impact on time and resources for debridement" 05/01/2006 - "PURPOSE: This study was designed to report a patient with a vernal shield ulcer that did not respond to medical therapy but healed in 1 week after surgical debridement of the ulcer base" Order ALL the reference details at left...

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