Abstract | BACKGROUND: METHODS: We performed a nested case-control study within 6 prospective cohort studies using 565 SCD cases matched to 1090 controls (1:2) by age, sex, ethnicity, smoking status, and presence of cardiovascular disease. RESULTS: The median study follow-up time until SCD was 11.3 years. When examined as quartiles or continuous variables in conditional logistic regression models, each of the biomarkers was significantly and independently associated with SCD risk after mutually controlling for cardiac risk factors and other biomarkers. The mutually adjusted odds ratios for the top compared with the bottom quartile were 1.90 (95% CI, 1.30-2.76) for total to high-density lipoprotein cholesterol ratio, 2.59 (95% CI, 1.76-3.83) for high-sensitivity cardiac troponin I, 1.65 (95% CI, 1.12-2.44) for NT-proBNP, and 1.65 (95% CI, 1.13-2.41) for high-sensitivity C-reactive protein. A biomarker score that awarded 1 point when the concentration of any of those 4 biomarkers was in the top quartile (score range, 0-4) was strongly associated with SCD, with an adjusted odds ratio of 1.56 (95% CI, 1.37-1.77) per 1-unit increase in the score. CONCLUSIONS: Widely available measures of lipids, subclinical myocardial injury, myocardial strain, and vascular inflammation show significant independent associations with SCD risk in apparently low-risk populations. In combination, these measures may have utility to identify individuals at risk for SCD.
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Authors | Brendan M Everett, M V Moorthy, Jani T Tikkanen, Nancy R Cook, Christine M Albert |
Journal | Circulation
(Circulation)
Vol. 142
Issue 12
Pg. 1148-1158
(09 22 2020)
ISSN: 1524-4539 [Electronic] United States |
PMID | 32700639
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Cholesterol, HDL
- Peptide Fragments
- Troponin I
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
- C-Reactive Protein
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Topics |
- Aged
- Biomarkers
- C-Reactive Protein
(metabolism)
- Cholesterol, HDL
(blood)
- Death, Sudden, Cardiac
- Female
- Heart Injuries
(blood, mortality)
- Humans
- Inflammation
(blood, mortality)
- Male
- Middle Aged
- Myocardium
(metabolism)
- Natriuretic Peptide, Brain
(blood)
- Peptide Fragments
(blood)
- Prospective Studies
- Troponin I
(blood)
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