Sudden Death

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2865 relevant articles (153 outcomes, 293 trials/studies) found for this Disease

Description: The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.

Also Known As:

Death, Sudden

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2442

Death: 1282

Sudden Death: 2865

Cardiac Sudden Death: 1699

Sudden Infant Death: 1596

Related Diseases

1.	Myocardial Infarction
2.	Heart Failure
3.	Tachycardia (Tachyarrhythmias)
4.	Cardiac Arrhythmias (Arrythmia)
5.	Coronary Artery Disease (Coronary Atherosclerosis)

Experts

1.	Maron, Barry J: 7 articles (10/2008 - 10/2004)
2.	Ilveskoski, Erkki: 5 articles (08/2008 - 10/2002)
3.	Lehtimäki, Terho: 5 articles (08/2008 - 10/2002)
4.	Karhunen, Pekka J: 5 articles (08/2008 - 10/2002)
5.	Zhang, Lin: 5 articles (05/2008 - 08/2002)
6.	Jiang, Dawei: 5 articles (05/2008 - 08/2002)
7.	Chen, S R Wayne: 5 articles (05/2008 - 08/2002)
8.	Thiene, Gaetano: 4 articles (09/2008 - 07/2002)
9.	Basso, Cristina: 4 articles (09/2008 - 07/2002)
10.	Mikkelsson, Jussi: 4 articles (08/2008 - 10/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sudden Death:

1.	Amiodarone (Amiodarona)FDA LinkGeneric 04/01/1994 - "beta-Blockers and amiodarone are effective in primary prevention of sudden death in selected populations. " 05/01/2007 - "The object of this study was to determine the incidence, dose, and time until onset of bilateral vision loss from amiodarone as a secondary end point in an investigation of amiodarone's role in preventing sudden death. " 05/01/1999 - "Assuming NSVT as a potential prognostic marker for sudden death, amiodarone treatment may have exerted a beneficial effect in these patients, but this statement is only a presumption due to the limitations of our study. " 03/11/1999 - "Several trials have evaluated the role of amiodarone in decreasing mortality in patients at high risk of developing sudden death. " 03/11/1999 - "Amiodarone and "primary" prevention of sudden death: critical review of a decade of clinical trials." Order ALL the reference details at left...
2.	Anti-Arrhythmia AgentsIBA 06/04/1992 - "Antiarrhythmic drugs have not been shown to be effective for preventing sudden death, although there are as yet no well-controlled randomized trials. " 11/01/1992 - "CONCLUSIONS: Several trials investigating the efficacy of antiarrhythmic drugs in decreasing sudden death have yielded disappointing results. " 07/01/1979 - "Thus, it may serve as a model to study sudden death and the efficacy of antiarrhythmic drugs." 09/01/2002 - "The efficacy of antiarrhythmic drugs and devices in preventing sudden death and reducing total mortality is uncertain. " 07/01/1996 - "Prevention of sudden death, reduction in total mortality, or improvement in symptoms remain the only benefits of antiarrhythmic drugs. " Order ALL the reference details at left...
3.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 11/01/1981 - "Pretreatment with aspirin, which uniformly inhibited platelet aggregation, was associated with a reduced incidence of sudden death (25%), but the difference between aspirin-treated and control animals lacked statistical significance. " 06/03/1995 - "Stable angina is an ideal application for low-dose aspirin with an improvement in combined incidence of myocardial infarction and sudden death of 34%. " 07/01/2003 - "Autopsy-proven shunt thrombosis is one of the leading causes of interim sudden death, and aspirin therapy may not be helpful. " 02/15/2001 - "Sudden death occurred seven days after acute gastrointestinal bleeding and subsequent interruption of aspirin therapy. " 10/01/1995 - "These low doses of aspirin, generally 75 mg, have been demonstrated, in stable angina, to decrease infarction and sudden death by more than 30%. " Order ALL the reference details at left...
4.	Omega-3 Fatty Acids (Omega 3 Fatty Acids)FDA Link 08/01/2003 - "Emphasis on foods rich in n-3 fatty acids shows promise for reducing cardiovascular outcomes, particularly sudden death." 03/01/2004 - "Clinical studies show that N-3 PUFA or fish oil supplementation appears to reduce mortality and sudden death. " 03/01/2002 - "The hypothesis that a protection from sudden death occurs because of antiarrhythmic effects of omega-3 fatty acids is supported by studies on cellular and animal models. " 05/01/2008 - "The role of omega-3 fatty acids in preventing sudden death continues to evolve." 02/01/2005 - "However, n-3 fatty acids decreased heart rate by 2.1 beats/min, a significant decrease that predicts a lower risk of sudden death." Order ALL the reference details at left...
5.	Propranolol (Inderal)FDA LinkGeneric 11/01/1978 - "All patients with this disorder should be treated with propranolol; surgical intervention, although it does not totally abolish the risk of sudden death, appears to offer symptomatic improvement in most cases over a long-term follow-up period." 06/01/1982 - "Nineteen of the 78 patients (24%) were taking propranolol in apparently adequate dosages, indicating that this drug does not provide absolute protection against sudden death. " 02/01/1998 - "The results of the Cox regression analysis, adjusting for all baseline variables with p values <0.25, showed the relative risk of overall mortality rate and the relative risk of sudden death were 2.13 ( 1.22, 3.70) and 2.56 (1.27, 5.26), respectively, for the placebo group compared with the propranolol group. " 02/01/1998 - "Sudden death in the placebo arm was 9.7% compared with 4.7% in the propranolol group (p = 0.012, log rank test). " 07/15/1990 - "Mortality was 7.8% (sudden death 4.8%) in the propranolol group and 7.9% (sudden death 4.8%) in the placebo group (p greater than 0.99, log rank test). " Order ALL the reference details at left...
6.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 12/01/2006 - "The use of highly concentrated and purified omega-3 polyunsaturated fatty acids (n-3 PUFAs), in addition to standard secondary prevention after MI, results in a significant reduction in the risk of sudden death. " 01/01/2006 - "The use of highly concentrated and purified omega-3 polyunsaturated fatty acids (n-3 PUFAs), in addition to standard secondary prevention after MI, results in a significant reduction in the risk of sudden death versus no n-3 PUFAs. " 06/01/2006 - "BACKGROUND: Omega-3 polyunsaturated fatty acids (omega3-PUFAs) from fish oil reduce the risk of sudden death presumably by preventing life-threatening arrhythmias. " 06/03/2003 - "The fish story: a diet-heart hypothesis with clinical implications: n-3 polyunsaturated fatty acids, myocardial vulnerability, and sudden death." 12/01/2002 - "Effect of n-3 polyunsaturated fatty acids on risk reduction of sudden death." Order ALL the reference details at left...
7.	CholesterolIBA 12/01/1980 - "In multivariate Cox regression, controlling for age, blood pressure, serum cholesterol, cigarettes smoked per day and relative weight, heart rate is a significant risk factor for sudden CHD death and non-CVD death in two of the three studies, with the association with sudden death being U-shaped in one of the studies. " 04/20/1999 - "Resting heart rate, systolic or diastolic blood pressure, tobacco consumption, body mass index, diabetes status, serum cholesterol, and parental history of sudden death were independent factors associated with sudden death during follow-up (23 years on average). " 12/01/1990 - "In asymptomatic persons the risk of sudden death varies over a wide range in relation to risk factors such as systolic blood pressure, serum cholesterol, cigarette smoking, heart rate, electrocardiographic abnormality and relative weight. " 01/01/2009 - "[Sudden death in patient with cholesterol atheroembolism]" 05/01/2001 - "When age, body mass index, systolic blood pressure, tobacco consumption, parental history of myocardial infarction and parental history of sudden death, cholesterol level, diabetic status, and sport activity were simultaneously entered into the survival model, resting heart rate remained an independent risk factor for sudden death (P=0.03) but not for fatal myocardial infarction. " Order ALL the reference details at left...
8.	Spironolactone (Aldactone)FDA LinkGeneric 09/02/1999 - "This 30 percent reduction in the risk of death among patients in the spironolactone group was attributed to a lower risk of both death from progressive heart failure and sudden death from cardiac causes. " 12/01/1962 - "Hyperkalemia and sudden death during Spironolactone (Aldactone) therapy." 01/01/2000 - "Similarly, for spironolactone, the RALES study showed a reduced incidence of sudden death in cardiac failure, as its physiopathological modes of action suggested. " 05/01/2005 - "The RALES study has shown that spironolactone reduces the risk of morbidity and mortality both from progressive heart failure and sudden death in patients with NYHA class III or IV heart failure. " 12/01/2001 - "Diuretics have generally been demonstrated to increase sudden death, possibly via electrolyte imbalance; this may explain why spironolactone has a pronounced impact in reducing sudden death. " Order ALL the reference details at left...
9.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 06/01/2001 - "The mechanism of ACE inhibitors benefits is multifactorial and includes prevention of progressive LV remodeling, prevention of sudden death and arrhythmogenicity and structural stability of the atherosclerotic process. " 06/01/2000 - "Sudden death and the electrophysiological effects of angiotensin-converting enzyme inhibitors." 01/01/2000 - "Sudden death: ACE inhibitors and beta-blockers." 05/22/1990 - "To date, however, ACE inhibitors have not been demonstrated to have a significant effect on the incidence of sudden death. " 08/01/1997 - "This influence of some ACE inhibitors on HRV may be beneficial in reducing the risk for sudden death in post-myocardial infarction patients." Order ALL the reference details at left...
10.	Sulfinpyrazone (Anturane)FDA Link 12/01/1980 - "This reduction was attributable primarily to a significant reduction in sudden death (37 in the placebo group vs 22 in the sulfinpyrazone group, sudden death mortality reduction of 43%, p = 0.023-0.041). " 12/01/1980 - "Interpretation of the data by time period and cause revealed that the effect of sulfinpyrazone was restricted to the prevention of sudden death during the high-risk period for this event, i.e., the first 6 months after trial entry (24 in the placebo group vs six in the sulfinpyrazone group, sudden death mortality reduction of 74%, p = 0.001-0.003)." 05/01/1982 - "We conclude that sulfinpyrazone has no clinical electrophysiological effects comparable with those of known antiarrhythmic agents and that a direct antiarrhythmic action is an unlikely explanation for the reduction of sudden death in postinfarction patients treated with this drug. " 01/01/1982 - "Beta-receptor-blockers and sulfinpyrazone on the other hand have proven to be effective at least as far as reduction of sudden death is concerned. " 04/04/1980 - "In the sulfinpyrazone group the reduction in cardiac mortality was 32 per cent (P =0,058) and the reduction in sudden death was 43 per cent (P = 0,041). " Order ALL the reference details at left...

Therapies and Procedures

1.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 04/01/2009 - "Therefore, identification of those patients at high risk of sudden death represents a major clinical problem and has become an even greater challenge since the implantable cardioverter-defibrillator (ICD) has proved to be highly effective in preventing sudden death in HCM. " 12/01/2007 - "Therefore, risk stratification for sudden death has a major role in the management of HCM and has acquired even greater relevance since the implantable cardioverter-defibrillator (ICD) has proved to be highly effective in preventing sudden death in this disease. " 03/11/1999 - "The implantable cardioverter defibrillator (ICD) is highly effective in the prevention of sudden death, but no mortality benefit in advanced CHF has yet been shown. " 03/01/1995 - "It has been shown that implantable cardioverter defibrillator (ICD) therapy has a low surgical mortality and is highly effective in the prevention of sudden death. " 02/01/1992 - "Highly efficacious therapy, such as the implantable cardioverter-defibrillator, may reduce the chance of sudden death, but broad application is limited by associated risks. " Order ALL the reference details at left...
2.	Defibrillators (Defibrillator) 03/01/2004 - "BACKGROUND: Implanted cardioverter defibrillator (ICD) is expensive but highly effective in preventing sudden death. " 05/01/2009 - "These observations also suggest that home automatic defibrillator strategies for sudden death prevention are unlikely to be effective in HCM." 10/01/2004 - "BACKGROUND: New evidence suggests that the implantable cardiac defibrillator (ICD) may be effective for primary prevention of sudden death. " 11/01/1995 - "Transvenous cardioverter defibrillators offer effective protection against sudden death. " 04/15/2006 - "Data from major randomized clinical trials involving the use of ICDs and cardiac resynchronization therapy-defibrillator devices were reviewed to determine control group mortality rates, control group sudden death rates, and the frequency of appropriate and inappropriate ICD therapies. " Order ALL the reference details at left...
3.	Drug Therapy (Chemotherapy) 05/01/1996 - "Comparison of ICD outcome with that of drug therapy in three large retrospective studies and two small prospective randomized trials favors improved survival and sudden death prevention with device therapy. " 02/01/2007 - "Contrary to the frequently repeated speculation that the risk stratification for sudden death and hence prophylactic placement of ICDs is reasonably accurate, there is little cost difference between pharmacotherapy and ICD treatment over the long term. " 10/01/2004 - "Drug therapy can reduce the incidence of sudden death in many subgroups of patients. " 03/01/2004 - "CONCLUSIONS: Using a standard cost-effectiveness threshold and plausible parameter ranges, it is unlikely that ICD is cost-effectiveness in preventing CHF sudden death relative to standard drug therapy." 03/01/2004 - "OBJECTIVE: To compare the cost-effectiveness of primary prophylactic ICD vs. standard drug therapy for preventing CHF sudden death. " Order ALL the reference details at left...
4.	Transplants (Transplant) 06/01/1997 - "CONCLUSION: The results of this preliminary study suggest that removal of a patient from a heart transplant waiting list may represent a risk for sudden death, particularly in patients with elevated ventricular filling pressures, irrespective of otherwise favorable clinical status and exercise performance." 03/01/1996 - "Animal studies have shown reasonable cadaveric graft function up to several hours after sudden death by drug administration. " 12/01/2007 - "Genotype-phenotype relationships revealed a high rate of sudden death and cardiac transplants in carriers of the p.N195K mutation. " 05/01/2000 - "The prevention of sudden death in these patients has been the focus of intensive research to achieve a larger number of patients who finally receive transplants. " 09/01/1998 - "Sudden death in heart transplant candidates has to be studied more intensively." Order ALL the reference details at left...
5.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 12/01/2003 - "AIM: The problem of postoperative sudden death and the effect of age, gender and association of coronary artery bypass grafting were studied after implantation of a bioprosthetic valve in aortic position. " 09/04/1993 - "MAIN OUTCOME MEASURES--Incidences of reinfarction, sudden death, and coronary artery bypass grafting in one year. " 12/01/1985 - "We concluded that coronary artery bypass surgery is beneficial to certain survivors of prehospital sudden death. " 01/01/1985 - "There are many potential approaches to the prevention of reinfarction and sudden death, but the proof of benefit as yet is confined to the use of beta-adrenoceptor blocking drugs and coronary artery bypass surgery. " 04/01/1978 - "Reduction of sudden death by aortocoronary bypass surgery--II." Order ALL the reference details at left...

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