Serum insulin-like growth factor-1 levels in neurodegenerative diseases.

Abstract

BACKGROUND:

We investigated serum insulin-like growth factor (IGF)-1 levels in patients with neurodegenerative diseases and correlated these levels with clinical parameters.

METHODS:

One hundred and fifty-six patients with neurodegenerative diseases were included in this study, and serum IGF-1 levels were determined.

RESULTS:

Serum IGF-1 levels (mean ± standard error) were not significantly different among the patients with different neurodegenerative diseases: Parkinson's disease (PD; n = 73), 112.1 ± 5.1 ng/mL; progressive supranuclear palsy (n = 15), 102.9 ± 8.3 ng/mL; multiple system atrophy (n = 22), 103.1 ± 37.6 ng/mL; Alzheimer's disease (AD; n = 18), 102.2 ± 9.4 ng/mL; amyotrophic lateral sclerosis (n = 6), 105.5 ± 27.4 ng/mL; dementia with Lewy bodies (n = 14), 82.4 ± 7.4 ng/mL; frontotemporal dementia (n = 6), 90.0 ± 17.0 ng/mL; and corticobasal syndrome (n = 2), 118.0 ± 14.0 ng/mL. In patients with PD, serum IGF-1 levels were negatively correlated with age and modified Rankin scale (mRS) scores and positively correlated with the striatal dopamine transporter-specific binding ratio and the frontal assessment battery score. In patients with AD, serum IGF-1 levels were negatively correlated with age, disease duration, and mRS scores.

CONCLUSION:

We found correlations of serum IGF-1 levels with frontal lobe and striatal dopaminergic function and disability in PD patients and with disability in AD patients. The usefulness of measuring serum IGF-1 levels for monitoring disease progression in neurodegenerative diseases requires further studies.

• Authors: Keisuke Suzuki, Shiho Suzuki, Yuko Ishii, Hiroaki Fujita, Takeo Matsubara, Madoka Okamura, Hirotaka Sakuramoto, Koichi Hirata
• Journal: Acta neurologica Scandinavica (Acta Neurol Scand) Vol. 139 Issue 6 Pg. 563-567 (Jun 2019) ISSN: 1600-0404 [Electronic] Denmark
• PMID: 30903695 (Publication Type: Journal Article)
• Copyright: © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Biomarkers
• IGF1 protein, human
• Insulin-Like Growth Factor I

Topics

• Aged
• Biomarkers (blood)
• Female
• Humans
• Insulin-Like Growth Factor I (analysis, metabolism)
• Male
• Middle Aged
• Neurodegenerative Diseases (blood)