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Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)

3210  relevant articles (63 outcomes, 328 trials/studies) found for this Disease

Description: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)

Also Known As:
Lou Gehrig's Disease; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Lou Gehrig Disease; ALS (Amyotrophic Lateral Sclerosis); Amyotrophic Lateral Sclerosis With Dementia; Amyotrophic Lateral Sclerosis, Guam Form; Dementia With Amyotrophic Lateral Sclerosis; Gehrig's Disease; Guam Form of Amyotrophic Lateral Sclerosis; Gehrig Disease; Gehrigs Disease; Lateral Scleroses, Amyotrophic; Lou Gehrigs Disease; Sclerosis, Amyotrophic Lateral

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neurodegenerative Diseases (Neurodegenerative Disease)
2. Multiple Sclerosis
3. Parkinson Disease (Parkinson's Disease)
4. Alzheimer Disease (Alzheimer's Disease)
5. Dementia (Dementias)

Experts

1. Beal, M Flint: 16 articles (06/2008 - 05/2002)
2. Iłzecka, J: 14 articles (01/2007 - 07/2000)
3. Brown, Robert H: 13 articles (08/2008 - 05/2002)
4. Kiaei, Mahmoud: 13 articles (01/2008 - 04/2003)
5. Andersen, Peter M: 10 articles (10/2008 - 06/2003)
6. Hayward, Lawrence J: 10 articles (08/2008 - 05/2002)
7. Calingasan, Noel Y: 10 articles (08/2007 - 04/2003)
8. Shaw, Pamela J: 10 articles (05/2007 - 06/2002)
9. Stelmasiak, Z: 10 articles (11/2003 - 07/2000)
10. Shimizu, N: 10 articles (06/2001 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Amyotrophic Lateral Sclerosis:
1. RiluzoleFDA LinkGeneric
2. AntioxidantsIBA
3. Insulin-Like Growth Factor I (IGF-1)IBA
4. Glutamic Acid (Glutamate)FDA Link
5. Thyrotropin-Releasing Hormone (Prolactin Releasing Hormone)FDA Link
6. Nerve Growth Factors (Neurotrophins)IBA
7. N-Methylaspartate (NMDA)IBA
8. gabapentin (Neurontin)FDA LinkGeneric
9. Quinidine (Chinidin)FDA LinkGeneric
10. Botulinum Toxins (Botulinum Toxin)IBA

Therapies and Procedures

1. Tracheostomy
2. Positive-Pressure Respiration (PEEP)
3. Mechanical Ventilators (Ventilator)
4. Transplantation (Transplant Recipients)
5. Gastrostomy

Best Treatments:
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