Abstract | INTRODUCTION: METHOD: RESULTS: At baseline, the patients with MDD + AUD showed higher levels of inflammatory biomarkers IL-6 (p < 0.001), hs-CRP (p < 0.01), YKL-40 (p < 0.05), and biomarkers of alcohol consumption, than the corresponding group of non-AUD patients. These differences disappeared during follow-up and recovery from depression. The level of IL-8 decreased significantly in both AUD (p < 0.05) and non-AUD (p < 0.05) patients. During follow-up, the biomarkers of alcohol consumption, GT and CDT, in AUD patients were found to decrease in parallel with serum YKL-40 levels. CONCLUSIONS: Alcohol consumption appears to modulate the status of inflammation in depressive patients. A more systematic use of biomarkers of inflammation together with biomarkers of alcohol consumption and liver status may prove to be of value in a more comprehensive assessment and treatment of patients with depression.
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Authors | Mari Archer, Onni Niemelä, Kaisa Luoto, Johanna Kultti, Mari Hämäläinen, Eeva Moilanen, Antti Koivukangas, Esa Leinonen, Olli Kampman |
Journal | Alcohol (Fayetteville, N.Y.)
(Alcohol)
Vol. 81
Pg. 21-26
(12 2019)
ISSN: 1873-6823 [Electronic] United States |
PMID | 30769022
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Cytokines
- C-Reactive Protein
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Topics |
- Adult
- Alcoholism
(complications)
- Biomarkers
(blood)
- C-Reactive Protein
(analysis)
- Cytokines
(blood)
- Depressive Disorder, Major
(complications)
- Female
- Follow-Up Studies
- Humans
- Inflammation
(blood, complications)
- Liver Function Tests
- Male
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