Abstract | RATIONALE: PATIENT CONCERNS: DIAGNOSES: INTERVENTIONS: OUTCOMES: There was an improvement in patient's respiratory status and repeat bronchoscopy at the end of treatment did not show diffuse alveolar hemorrhage. LESSONS: Pauci-immune crescentic necrotizing glomerulonephritis is usually associated with the presence of ANCA, however, ANCA may be absent in 10% of these cases. Immunosuppression is the mainstay of treatment for ANCA and anti-GBM associated PRS. This case highlights the importance of immunosuppression and plasmapheresis in patients with ANCA negative vasculitis due to presence of unidentified serum antibodies. If left untreated, these patients can have a fulminant course with high mortality ranging from 25 to 50%.
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Authors | Lakshmi Saladi, Danial Shaikh, Muhammad Saad, Enny Cancio-Rodriguez, Vivette D D'Agati, Boris Medvedovsky, Kalpana A Uday, Muhammad Adrish |
Journal | Medicine
(Medicine (Baltimore))
Vol. 97
Issue 23
Pg. e10954
(Jun 2018)
ISSN: 1536-5964 [Electronic] United States |
PMID | 29879042
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies, Antineutrophil Cytoplasmic
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Topics |
- Aged, 80 and over
- Antibodies, Antineutrophil Cytoplasmic
(immunology)
- Glomerulonephritis
(immunology)
- Hemorrhage
(immunology)
- Humans
- Lung Diseases
(immunology)
- Male
- Pulmonary Alveoli
(immunology)
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