Anti-Glomerular Basement Membrane Disease (Goodpasture's Syndrome)

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496 relevant articles (14 outcomes, 32 trials/studies) found for this Disease

Description: An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.

Also Known As:

Goodpasture's Syndrome; Goodpasture Syndrome; Anti GBM Disease; Syndrome, Goodpasture's; Lung Purpura with Nephritis; Anti Glomerular Basement Membrane Disease; Goodpastures Syndrome; Syndrome, Goodpasture; Anti-GBM Disease

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Systemic Lupus Erythematosus (Libman-Sacks Disease)
2.	Glomerulonephritis
3.	Hemorrhage
4.	Syndrome
5.	Myasthenia Gravis

Experts

1.	Turner, A Neil: 2 articles (02/2004 - 01/2003)
2.	Kalluri, R: 2 articles (06/2000 - 03/2000)
3.	Colon, Selene: 1 article (10/2008)
4.	Fervenza, Fernando: 1 article (10/2008)
5.	Zacharias, James: 1 article (10/2008)
6.	Ho, Julie: 1 article (10/2008)
7.	Gibson, Ian W: 1 article (10/2008)
8.	Borza, Dorin-Bogdan: 1 article (10/2008)
9.	Jayne, David R: 1 article (08/2008)
10.	Clatworthy, Menna R: 1 article (08/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Anti-Glomerular Basement Membrane Disease:

1.	antiglomerular basement membrane antibodyIBA 04/01/1988 - "This case illustrates that life-threatening relapse may occur in Goodpasture's syndrome despite a prolonged remission and the disappearance of detectable antiglomerular basement membrane antibody in the circulation." 05/01/2006 - "In this study, we investigated the effect of IA on serum anti-GBM level and evaluated its clinical efficacy in patients with Goodpasture's syndrome" 07/01/1995 - "As with recent studies in human anti-GBM disease, there was no evidence for affinity maturation of the anti-GBM response in the serum of any of the animal models" 01/01/1991 - "Renal biopsy immunofluorescence and serum antiglomerular basement membrane antibody titer studies confirmed the diagnosis of Goodpasture's syndrome" 05/01/2006 - "Anti-GBM, together with the additional nephritogenic potential of anti-dsDNA and anti-NuA, may play an essential role in the pathogenesis of the anti-GBM disease in LN" Order ALL the reference details at left...
2.	Cyclophosphamide (Cytoxan)FDA Link 06/15/1982 - "Goodpasture's syndrome--rapid remission after early plasmapheresis and high-dose cyclophosphamide therapy (author's transl)]" 08/01/1999 - "These findings suggest that cyclophosphamide pulse therapy is effective against Goodpasture's syndrome with massive pulmonary hemorrhage showing resistance to other conventional therapy." 08/01/1999 - "A case of Goodpasture's syndrome with massive pulmonary hemorrhage ameliorated by cyclophosphamide pulse therapy]" 04/01/1976 - "Repeated plasm exchanges were performed in a 44-year-old man with Goodpasture syndrome, also treated with cyclophosphamide and prednisone" 01/01/2005 - "The initial diagnosis was one of antiglomerular basement membrane (anti-GBM) disease that responded well to steroids, cyclophosphamide, and plasma exchange (PE)" Order ALL the reference details at left...
3.	AntibodiesIBA 03/01/2008 - "INTRODUCTION: The diagnosis of the pulmonary forms of Goodpasture's syndrome is not easy and requires a renal biopsy when no anti-glomerular basement membrane antibodies are detected, since the disease can lead to spontaneous massive intra-alveolar haemorrhage that can be fatal" 07/01/2006 - "Alveolar haemorrhage in anti-glomerular basement membrane disease without detectable antibodies by conventional assays." 02/01/2006 - "BACKGROUND: The role of anti-glomerular basement membrane (GBM) antibodies in the pathogenesis of Goodpasture syndrome (GPS) is firmly established" 02/01/2006 - "Anti-glomerular basement membrane antibodies in the diagnosis of Goodpasture syndrome: a comparison of different assays." 04/06/2005 - "OBJECTIVE: To investigate the avidity of anti-glomerular basement membrane (GBM) antibodies and their association with clinical and pathological parameters of patients with anti-GBM disease" Order ALL the reference details at left...
4.	SteroidsIBA 04/01/1984 - "A patient with auto-antibody mediated Goodpasture's syndrome was successfully treated with cytotoxic drugs, steroids and plasma exchange" 04/03/1976 - "Seven patients with Goodpasture's syndrome induced by anti-glomerular-basement-membrane (anti-G.B.M.) antibody were treated by a regimen of intensive plasma-exchange, cytotoxic drugs, and steroids" 10/01/1984 - "Partial recovery of renal function in an oligoanuric patient affected with Goodpasture's syndrome after treatment with steroids, immunosuppressives and plasmapheresis." 05/01/1981 - "Both were both in Puerto Rico and had left the island six to 15 years previously; both were receiving adrenal steroids (one for Hodgkin's disease and the other for Goodpasture's syndrome)" 03/01/2007 - "The combination of plasmapheresis with these cytotoxic agents and steroids is effective in patients with Goodpasture's syndrome, especially if instituted early in the course of the disease" Order ALL the reference details at left...
5.	Immunoglobulin G (IgG)IBA 05/01/1988 - "Direct immunofluorescence studies of tissue from a patient with Goodpasture's syndrome revealed deposition of IgG in the choroid plexus and eye, as well as in the kidney and lung." 11/01/2007 - "Goodpasture's syndrome is histologically diagnosed by intense linear deposits of IgG along the glomerular basement membrane in both renal and lung tissues." 04/01/2007 - "Linear anti-glomerular basement membrane IgG but no glomerular disease: Goodpasture's syndrome restricted to the lung." 12/01/2006 - "IF-P was less sensitive than IF-F for the detection of C3 in all disease categories and for the detection of IgG in cases of MGN and anti-GBM disease" 10/01/2004 - "The IgG1 subclass was mainly found in male patients and IgG4 subclass in female patients with anti-GBM disease" Order ALL the reference details at left...
6.	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 01/01/2008 - "Goodpasture's syndrome with positive C-ANCA and normal renal function: A case report." 08/01/1999 - "The current literature on ANCA-positive anti-GBM disease is briefly reviewed" 01/01/1999 - "Goodpasture's syndrome with P-ANCA was diagnosed" 01/01/1994 - "Of these, 10 had anti-GBM disease, 35 had epithelial proliferation associated with a variety of other diseases, and 36 had ANCA-associated disease" 10/23/1993 - "Goodpasture's syndrome with antineutrophil cytoplasmic antibodies]" Order ALL the reference details at left...
7.	Antigen-Antibody Complex (Immune Complex)IBA 01/01/2006 - "The immune complexes deposited in glomeruli might participate in the initiation of anti-GBM disease." 01/01/2006 - "Clinical and pathological data of patients with immune complex deposition (n = 10) were compared with those of patients with anti-GBM disease alone (n = 37)" 01/01/2006 - "In the current series, glomerular immune complexes were identified in 10 of 47 patients who presented with renal-biopsy-proven anti-GBM disease" 01/01/2006 - "However, the concurrent glomerular immune complex deposition was not rare and might be contributed to the development of anti-GBM disease" 08/01/1989 - "In the series, glomerular immune complexes were identified in 6 of 17 patients who initially presented with anti-GBM disease" Order ALL the reference details at left...
8.	Immunoglobulin A (IgA)IBA 09/01/1999 - "The emerging spectrum of IgA-mediated renal diseases: is there an IgA variant of Goodpasture's syndrome?" 04/01/1990 - "The diagnosis of Goodpasture's syndrome with IgA antibasement membrane antibody was made" 04/01/1990 - "This is a very rare case report of Goodpasture's syndrome with IgA antibasement membrane antibody" 04/01/1990 - "A case of Goodpasture's syndrome with IgA antibasement membrane antibody]" 07/01/1979 - "Immunoglobulin A antibasement membrane antibody must be considered in the design of immunoserologic procedures for the diagnosis of Goodpasture's syndrome." Order ALL the reference details at left...
9.	CytotoxinsIBA 03/01/2007 - "The combination of plasmapheresis with these cytotoxic agents and steroids is effective in patients with Goodpasture's syndrome, especially if instituted early in the course of the disease" Order ALL the reference details at left...
10.	Thomsen-Friedenreich antibodiesIBA 01/01/1994 - "Further work is necessary to determine whether anti-T cell therapy is effective in established EAG, and may be worth investigating in human anti-GBM disease." Order ALL the reference details at left...

Therapies and Procedures

1.	Plasmapheresis 07/01/2004 - "The second important thing in Goodpasture's syndrome is that treatment must be very aggressive using a combination of immunosuppressives and plasmapheresis" 11/01/1996 - "Goodpasture syndrome: treatment initiation with plasmapheresis before histologic diagnostic verification]" 01/01/1994 - "Goodpasture's syndrome in childhood: treatment with plasmapheresis and immunosuppression." 04/01/1990 - "This article describes a case of Goodpasture's syndrome controlled by double filtration plasmapheresis (DFPP) combined with steroid and immunosuppressant therapy" 04/01/1990 - "Double filtration plasmapheresis in case of Goodpasture's syndrome]" Order ALL the reference details at left...
2.	Blood Component Removal (Apheresis) 05/01/2003 - "These results suggest that granulocyte and monocyte apheresis may be of benefit in the therapy of a patient with ulcerative colitis who previously had Goodpasture syndrome" 05/01/1991 - "Apheresis therapies can be performed in the ICU to manage a number of neurologic, hematologic, and autoimmune disorders, including myasthenia gravis, Guillain-Barré syndrome, sickle-cell disease, and Goodpasture's syndrome" 07/01/2003 - "Apheresis has dramatically improved the prognosis and outcome in patients with myasthenia gravis, Guillain-Barré syndrome, Goodpasture syndrome and thrombotic thrombocytopenic purpura" 01/01/1983 - "Apheresis can be useful in the treatment of many other disorders, most notably myasthenia gravis, glomerulonephritis associated with hemoptysis (Goodpasture's syndrome), refractory systemic lupus erythematosus, cryoglobulinemia and immune cytopenic disorders." Order ALL the reference details at left...
3.	Plasma Exchange 04/01/2007 - "In 1976, Lockwood demonstrated the place of plasma exchanges (PE) in Goodpasture's syndrome [Lockwood CM, Rees AJ, Pearson TA, Evans DJ, Peters DK, Wilson CB" 01/26/1985 - "Plasma exchange in Goodpasture's syndrome." 01/01/1985 - "Since 1919 about 400 cases with Goodpasture's syndrome have been published, and since 1975 about 100 of these patients were treated with plasma exchange in addition to immunosuppression" 01/01/1985 - "Fatal relapse in Goodpasture's syndrome 3 years after plasma exchange." 01/01/1984 - "Immediate plasma exchange and immunosuppressive drug treatment have been recommended for Goodpasture's syndrome" Order ALL the reference details at left...
4.	Tissue Therapy (Cell Therapy) 01/01/1994 - "Further work is necessary to determine whether anti-T cell therapy is effective in established EAG, and may be worth investigating in human anti-GBM disease." Order ALL the reference details at left...
5.	Kidney Transplantation 02/01/2004 - "Recurrence of anti-GBM disease 8 years after renal transplantation." 01/01/2003 - "METHODS: We studied the outcome of renal transplantation in patients with pauciimmune SVV or anti-GBM disease, transplanted in our center between 1968 and 2000" 07/01/2001 - "To the best of our knowledge, this is the first report of renal transplantation for Goodpasture's syndrome in the Japanese literature." 07/01/2001 - "Cadaveric renal transplantation for Goodpasture's syndrome: a case report]" 02/27/2000 - "Some patients who undergo renal transplantation lose their kidneys as a result of posttransplant anti-glomerular basement membrane (anti-GBM) disease" Order ALL the reference details at left...

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