Respiratory Insufficiency (Respiratory Failure)

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10372 relevant articles (505 outcomes, 747 trials/studies) found for this Disease

Description: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)

Also Known As:

Respiratory Failure; Ventilatory Depression; Depressions, Ventilatory; Respiratory Depression

Relationship Network

Disease Context: Research Results

Respiratory Tract Diseases: 377

Respiration Disorders: 11

Respiratory Insufficiency: 10372

Airway Obstruction: 3004

Hypoventilation: 892

Respiratory Acidosis: 676

Respiratory Paralysis: 265

Intrinsic Positive-Pressure Respiration: 128

Hantavirus Pulmonary Syndrome: 40

Laryngeal Granuloma: 17

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD)
2.	Pain (Aches)
3.	Pulmonary Edema
4.	Pneumonia (Pneumonitis)
5.	Vomiting

Experts

1.	Finer, N N: 11 articles (01/2007 - 01/2000)
2.	Barrington, K J: 10 articles (01/2007 - 01/2000)
3.	Antonelli, M: 7 articles (11/2001 - 01/2000)
4.	Dahan, Albert: 6 articles (01/2008 - 02/2003)
5.	Sinuff, Tasnim: 6 articles (07/2005 - 03/2003)
6.	Schönhofer, B: 5 articles (08/2008 - 04/2000)
7.	Field, D: 5 articles (03/2008 - 01/2002)
8.	Elbourne, D: 5 articles (03/2008 - 01/2002)
9.	Hill, Nicholas S: 5 articles (10/2007 - 12/2003)
10.	Ehrenkranz, Richard A: 5 articles (07/2007 - 08/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Respiratory Insufficiency:

1.	OxygenIBA 01/01/2008 - "CONCLUSIONS: The high-flow oxygen therapy system is effective in a large percentage of children with high oxygen requirements and/or moderate respiratory failure." 01/01/2008 - "OBJECTIVE: To analyze the efficacy of a high-flow oxygen therapy system in children with moderate respiratory failure and/or high oxygen requirements. " 12/01/1990 - "These results suggest that PCV may be a beneficial ventilatory modality in the treatment of severe respiratory failure since it results in improvement in arterial oxygenation, tissue oxygen delivery and utilization without any concomitant adverse effects on other hemodynamic or ventilatory factors." 10/01/1986 - "Four patients with acute respiratory failure had a significant decrease in PaCO2, HCO3-, and BE and an increase in arterial oxygen pressure, indicating that in both of these patient groups alveolar ventilation had improved. " 11/22/1996 - "Closer adherence to more recently published international guidelines and better targeting of patients with respiratory failure will impose a greater financial burden on the oxygen service, but may result in improved survival and reduced need of hospital admission. " Order ALL the reference details at left...
2.	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/01/2007 - "BACKGROUND: Inhaled nitric oxide (iNO) has been proven to be effective in term infants with hypoxic respiratory failure. " 01/01/2006 - "BACKGROUND: Inhaled nitric oxide has been proven effective in term infants with hypoxic respiratory failure. " 01/01/2001 - "BACKGROUND: Inhaled nitric oxide has been proven effective in term infants with hypoxic respiratory failure. " 01/01/2001 - "BACKGROUND: Inhaled nitric oxide has been proven effective in term infants with hypoxic respiratory failure. " 01/01/2003 - "Initial studies examining the effect of inhaled nitric oxide in respiratory failure demonstrated transient improvement in oxygenation but did not examine mortality or other significant morbidity outcomes. " Order ALL the reference details at left...
3.	Morphine (MS Contin)FDA LinkGeneric 03/01/1993 - "When EA was administered together with morphine, peristalsis of the duodenum was much less inhibited (P < 0.05, vs morphine alone group), but no significant improvement of respiratory depression was noticed (P > 0.05), nor obvious change of arterial pressure in both groups. " 12/01/1996 - "However, NOS inhibitor treatment is more effective in suppressing morphine-induced ventilatory depression when given before, rather than after, morphine administration. " 03/01/2005 - "These changes were maintained at 30 min. Follow up treatment with oral morphine remained effective in reducing the symptom of breathlessness and no patient showed signs of respiratory depression. " 01/01/2008 - "The aim of this study was to describe respiratory depression associated with intrathecal morphine in postcesarean women, and to estimate its incidence. " 10/15/2006 - "Previous studies have looked at the use of intrathecal morphine and conclude that it is effective but also associated with respiratory depression. " Order ALL the reference details at left...
4.	Carbon DioxideIBA 06/01/2006 - "CONCLUSION: The 6-month NNPPV treatment significantly decreased the partial pressure of carbon dioxide and improved daytime respiratory muscle function, thus contributing to exercise-capacity increase in patients with chronic respiratory failure." 04/01/2008 - "The aim of this study was to assess the usefulness of SenTec Digital Monitor System in measuring transcutaneous arterial carbon dioxide partial tension (PCO2) non-invasively for the management of chronic respiratory failure. " 04/01/2006 - "Addition of carbon dioxide to the hypoxic exposure eliminated the respiratory depression. " 08/01/2001 - "Total extracorporeal arteriovenous carbon dioxide removal in acute respiratory failure: a phase I clinical study." 07/01/2001 - "The first study established a method for the noninvasive and indirect estimation of arterial carbon dioxide pressure that was suitable for the routine clinical monitoring of respiratory failure and whose clinical utility remains to this day, but which also provided observations that were the stimulus for the studies that followed. " Order ALL the reference details at left...
5.	Naloxone (Narcan)FDA LinkGeneric 12/01/1980 - "Respiratory depression was treated successfully with naloxone." 01/03/2005 - "CONCLUSION: IN naloxone is effective in treating opiate-induced respiratory depression, but is not as effective as IM naloxone. " 07/01/2003 - "CONCLUSIONS: There is a need for a randomised controlled trial to determine if naloxone confers any clinically important benefits on newborn infants with respiratory depression that may be due to transplacentally acquired narcotic." 01/01/2002 - "REVIEWER'S CONCLUSIONS: There is a need for a randomised controlled trial to determine if naloxone confers any clinically important benefits to newborn infants with respiratory depression that may be due to trans-placentally acquired narcotic." 08/01/1988 - "Clinical reports, as well as animal studies, have described cardiovascular and sympathetic stimulation after the administration of naloxone (NX) to reverse opioid-induced respiratory depression. " Order ALL the reference details at left...
6.	GasesIBA 02/01/1989 - "The results of this study indicate that both HFPPV and HFJV are effective in short-term maintenance of normal blood gases in respiratory failure without any discernable differences in their effects on cardiovascular function. " 06/01/1998 - "In conclusion, in the tested settings VPAP-S/T is as effective as BiPAP-S/T in maintaining ventilation and controlling blood gases during sleep in patients with stable respiratory insufficiency." 12/01/1984 - "Surfactant replacement restores blood gases to normal in adult experimental animals with severe respiratory insufficiency induced by repeated lung lavage, suggesting that this type of treatment might be effective in clinical adult RDS." 01/01/2000 - "Up to 24 h after the start of ventilatory support blood gases were improved to values characteristic for partial respiratory insufficiency. " 01/01/1968 - "[Study of the variations of arterial blood gases during a 24-hour period in chronic respiratory insufficiency]" Order ALL the reference details at left...
7.	Methylprednisolone FDA LinkGeneric 04/01/1997 - "Concerning respiratory failure after open heart surgery, however, we think that a respiratory function of a patient is improved if high-dose methylprednisolone pulse therapy is started in early stage." 06/13/2000 - "There was improvement when methylprednisolone was given to three of the patients, but one patient died of respiratory failure. " 02/01/2003 - "Preoperative administration of methylprednisolone attenuates cytokine-induced respiratory failure after esophageal resection." 10/01/1999 - "Corticosteroid therapy (2 courses of pulse therapy, each consisting of methylprednisolone at 500 mg/day for 3 days) was not effective, and the patient died 9 weeks after onset because of respiratory failure. " 07/01/1998 - "She was treated with methylprednisolone pulse therapy, but died of respiratory failure. " Order ALL the reference details at left...
8.	Adrenal Cortex Hormones (Corticosteroids)IBA 05/01/1995 - "carinii-related respiratory failure, only adjunctive corticosteroids were associated with a significant improvement in survival to successful removal of the tracheal tube, from a historical rate of 11% to 91%." 12/01/2007 - "The patient was treated with systemic corticosteroids and had complete resolution of respiratory failure and pulmonary infiltrates. " 01/01/2007 - "Therapy with corticosteroids led to a short improvement, however the patient died 1 week after the initiation of corticosteroid treatment due to respiratory insufficiency. " 12/01/2006 - "Concomitant treatment with corticosteroids should be used in those cases with respiratory insufficiency." 04/01/2006 - "Treatment involves discontinuation of the offending drug or toxin and treatment with corticosteroids in severe respiratory failure. " Order ALL the reference details at left...
9.	Fentanyl (Sublimaze)FDA LinkGeneric 09/01/2008 - "BACKGROUND: Many studies have been conducted to assess the effects of fentanyl on the autonomic nervous system (ANS) by heart rate variability (HRV) analysis, but disagreement on the results is still present due to confounding influences introduced by concomitant administration of other drugs or opioid-related transitory respiratory depression. " 05/01/2007 - "Judicious monitoring for opioid-induced respiratory depression is recommended for fentanyl ITS, although this adverse effect has not been observed in clinical trials. " 03/01/2004 - "The aim of this study was to evaluate the validity of the SCSB compared with the respiratory inductive plethysmograph (RIP) using a fentanyl-induced respiratory depression model. " 08/31/2009 - "Ampakine therapy to counter fentanyl-induced respiratory depression." 06/01/2009 - "RESULTS: Preadministration of CX717 markedly attenuated fentanyl-induced respiratory depression. " Order ALL the reference details at left...
10.	Midazolam (Versed)FDA LinkGeneric 10/15/2005 - "Respiratory depression, assessed by the elevation in PaCO2, was more closely correlated with midazolam striatal dialysate rather than plasma kinetics. " 04/01/2004 - "Midazolam should be offered only to hemodynamically stable patients without preceding respiratory depression." 12/01/2002 - "Furthermore, midazolam potentially reduces respiratory depression and time to treatment." 06/01/2002 - "Midazolam could be used in patients with cardiac, or respiratory failure, and in neurosurgery. " 04/01/2002 - "None were intubated on arrival and none were felt to require intubation secondary to midazolam-induced respiratory depression. " Order ALL the reference details at left...

Therapies and Procedures

1.	Artificial Respiration (Mechanical Ventilation) 11/01/1994 - "The following conclusions are drawn from critical evaluation of the collected data: (1) Closed system positive pressure mechanical ventilation applied at mild to moderate levels of intensity is a safe and effective method for augmenting deficient blood gas exchange in most patients who are in acute respiratory failure. " 06/01/1997 - "Respiratory failure developed within 54 h and CO2 could not be eliminated, even by very invasive mechanical ventilation. " 12/01/2005 - "STUDY OBJECTIVE: Noninvasive mechanical ventilation (NIMV) is beneficial for patients with acute respiratory failure (ARF) when added to medical treatment. " 11/01/2008 - "BACKGROUND AND OBJECTIVES: Noninvasive home mechanical ventilation (HMV) has been shown to be beneficial for certain forms of respiratory failure, improving symptoms and quality of life. " 11/01/2002 - "BACKGROUND: Home mechanical ventilation (HMV) is known to be a successful therapy for chronic respiratory insufficiency, with regard to long-term survival. " Order ALL the reference details at left...
2.	Positive-Pressure Respiration (PEEP) 10/01/2005 - "In particular, noninvasive positive pressure ventilation (NIPPV) is effective in resolving respiratory failure and has dramatically changed the management of these patients. " 01/01/2007 - "OBJECTIVE: In randomized studies of heterogeneous patients with hypoxemic acute respiratory failure, noninvasive positive pressure ventilation (NPPV) was associated with a significant reduction in endotracheal intubation. " 01/01/2003 - "In this case, recruitment maneuver and high PEEP relieved postoperative respiratory failure. " 02/01/1975 - "We conclude that high levels of PEEP can be therapeutic for patients with refractory respiratory failure when combined with intermittent mandatory ventilation and careful cardiovascular monitoring. " 05/01/2007 - "Noninvasive positive-pressure ventilation (NPPV) has been a major advance in the management of acute respiratory failure. " Order ALL the reference details at left...
3.	Extracorporeal Membrane Oxygenation (ECMO) 07/01/1996 - "We then present our experience from the past 11 years in the most invasive, yet successful, therapy for acute respiratory failure-extracorporeal membrane oxygenation (ECMO). " 01/01/2006 - "While extracorporeal membrane oxygenation is proven to result in improved outcome when compared to conventional ventilation in neonates with severe respiratory failure, there is currently no good evidence from randomised controlled trials to compare these managements for important clinical outcomes in adults, although evidence from case series is promising. " 01/01/2008 - "AUTHORS' CONCLUSIONS: A policy of using ECMO in mature infants with severe but potentially reversible respiratory failure results in significantly improved survival without increased risk of severe disability. " 01/01/2002 - "REVIEWER'S CONCLUSIONS: A policy of using ECMO in mature infants with severe but potentially reversible respiratory failure would result in significantly improved survival without increased risk of severe disability amongst survivors. " 12/01/1997 - "CONCLUSIONS: We conclude that AVCO2R in a simple arteriovenous shunt is a less complicated technique than extracorporeal membrane oxygenation and is capable of total CO2 removal that allows a significant reduction in the minute ventilation and peak airway pressure during severe respiratory failure." Order ALL the reference details at left...
4.	Mechanical Ventilators (Ventilator) 08/01/1996 - "CONCLUSIONS: Administration of calf's lung surfactant appears to be safe and is associated with rapid improvement in oxygenation and moderation of ventilator support in children with acute hypoxemic respiratory failure. " 06/01/1981 - "Results indicate that regular efficient night-time support by body respirator provides a constant significant improvement in daytime gas exchange for periods averaging up to 2 years following the occurrence of moderately severe respiratory failure. " 07/01/1989 - "Home care of ventilator-dependent people is increasing in use due to improved management of respiratory failure and the development of effective portable ventilators. " 02/01/1991 - "The results of this initial trial suggest that the volumetric diffusive respirator is a safe and effective method of ventilation in neonates with respiratory failure and that the survival rate in such neonates might be enhanced if treatment is introduced earlier in the disease." 11/01/1990 - "Pulmonary function tests, particularly repeated vital capacity measurements, are very useful to predict respiratory failure and conduct weaning trials from the respirator. " Order ALL the reference details at left...
5.	Drug Therapy (Chemotherapy) 09/01/2003 - "Nowadays, with increasing efficacy of antituberculosis chemotherapy, application of GCS is limited to selected cases of TP (mainly complicated by toxaemia and/or respiratory failure)." 03/01/1997 - "The patient received chemotherapy and responded well, but he died of respiratory failure 26 months later. " 11/01/1990 - "Changes in the management of patients with PCP have included different dosages and routes of administration for chemotherapy, improved overall survival, and a recent increase in the number of patients surviving episodes of respiratory failure. " 01/01/1989 - "The neuropathy initially improved following chemotherapy, but subsequently progressed to the point of respiratory failure. " 06/01/1966 - "[Studies on the objectivation of a pharmacotherapy of respiratory insufficiency described on the example of homoveratric acid dimethyl-amide]" Order ALL the reference details at left...

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